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Strategies in Clinical Hematology (Paperback, 1979 ed.)
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Strategies in Clinical Hematology (Paperback, 1979 ed.)
Series: Recent Results in Cancer Research, 69
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Our present knowledge in the fields of both experimental and
clinical hematology has rapidly progressed because of the
complementary aspect one offers the other. In light of the above,
basic research is a prerequisite for both diagnostic and
therapeutic advances. Thus it would seem justified to review the
pathogenesis of hemoblastoses and the experiences resulting from
those animal experiments which are trans- ferable to human
conditions. The association of Epstein-Barr virus infection with
Burkitt's lymphoma appeared to be a model for the viral etiology of
human neoplasias, the subject of many decades discussion. Although
there is evidence for the correlation, the exact role of the virus
in the etiology of the disease still remains to be clarified. In
public, attention has been focused on the induc- tion of neoplasia
by environmental factors. For the hema- tologist the induction
ofhemoblastoses by immunosuppressive and cytostatic drugs gains
increasing significance as a result of the wider use of these
agents - not only cytotoxic cancer therapy, but also in treating
autoimmune diseases and in managing transplantation problems.
Physiology of the human stem cell has been intensively studied, and
the presently available in vitro tests are of clinical use and
enable greater understanding of pathophysiology, especially that of
aplastic anemias and leukemias. Immunologic and biochemical mark-
ers have been of value in leukemias and malignant lym- phomas, both
as diagnostic tools and as prognostic parameters.
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