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Handbook of HER2-targeted agents in breast cancer (Paperback, 2013 ed.)
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Handbook of HER2-targeted agents in breast cancer (Paperback, 2013 ed.)
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Breast cancer is the most frequently diagnosed cancer and the
leading cause of cancer death in women worldwide, accounting for
nearly a quarter of the total new cancer cases each year. Of these
cases, approximately 15-25% overexpress HER2, a transmembrane RTK
kinase that is associated with aggressive tumor growth and poor
outcomes. However, in the past decade, survival rates of patients
with HER-positive breast cancer have significantly improved due to
increased screening, HER2 testing, and breakthrough HER2-targeted
drug therapies. Handbook of HER2-Targeted Agents in Breast Cancer
provides oncologists, primary care physicians, trainees and other
healthcare providers with a concise, accessible, and up-to-date
survey of the field, including a review of our current
understanding of the biology of the HER2 pathway and the rationale
for targeting it in early-stage and advanced breast cancer, an
overview of HER2-testing, and evidence-based discussions of
available HER2-targeted regimens in the adjuvant and metastatic
settings.
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