Adeno-Associated Virus - Methods and Protocols (Paperback, Softcover reprint of the original 1st ed. 2011)

Today, progress in rAAV-mediated gene transfer is so robust that long-term, efficient, and regulatable transgene expression is reproducibly achieved in large animal models. The complexity of gene transfer agents in the context of their clinical use requires investigators from a wide variety of backgrounds to have an understanding - or at least an appreciation of - the regulatory environment and constraints that affect vector design, manufacturing, pre-clinical testing, and clinical use, with an emphasis on patient protection. In Adeno-Associated Virus: Methods and Protocols, experts from the United States and Europe have contributed current knowledge of this multi-dimensional field relating to the biology of AAV, rAAV vector design, vector manufacturing and product testing, performance of rAAV vectors in major organs, rAAV-related immunological issues, design of animal and clinical studies, and clinical experience. Written in the successful Methods in Molecular Biology (TM) series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and accessible, Adeno-Associated Virus: Methods and Protocols provides a complete and comprehensive understanding of this multi-disciplinary and rapidly progressing field.

General

Imprint:	HumanaPress
Country of origin:	United States
Series:	Methods in Molecular Biology, 807
Release date:	August 2016
First published:	2011
Editors:	Richard O. Snyder • Philippe Moullier
Dimensions:	254 x 178mm (L x W)
Format:	Paperback
Pages:	462
Edition:	Softcover reprint of the original 1st ed. 2011
ISBN-13:	978-1-4939-6175-7
Categories:	Books > Medicine > Pre-clinical medicine: basic sciences > Medical genetics Books > Medicine > Clinical & internal medicine > Gene therapy Books > Science & Mathematics > Biology, life sciences > Zoology & animal sciences > Animal reproduction
LSN:	1-4939-6175-6
Barcode:	9781493961757

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