The design of efficient syntheses of medicinal agents is one of
the prime goals of the process chemist in the pharmaceutical
industry. The expanding list of metal-mediated reactions has had a
major impact on this endeavor over the last two decades. This
volume will highlight some of the areas of organometallic chemistry
that have played a particularly important role in development. The
chapters are written by chemists who work in the process groups of
major pharmaceutical companies and fine chemical manufacturers.
Having demonstrated the power of organometallics in their processes
the authors herein expand upon their experiences with examples from
the literature as reported by process groups within the industry.
The chapters are organized either by the application of a
particular metal or reaction class. Removal of the residual
metal(s) from the isolated active pharmaceutical ingredient (API)
is key to the release of the material for human consumption, and
hence, is reviewed here as well. This volume of Topics in
Organometallic Chemistry is presented to offer a representative
cross section of organometallic applications in the pharmaceutical
industry as well as to give an appreciation for the creativity
possible in process chemistry.
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