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Books > Medicine > Clinical & internal medicine > Haematology
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Plasmapheresis & Intravenous Immunoglobin - Clinical Uses, Potential Complications & Long-Term Health Effects (Hardcover)
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Plasmapheresis & Intravenous Immunoglobin - Clinical Uses, Potential Complications & Long-Term Health Effects (Hardcover)
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Plasmapheresis is a therapeutic tool used to treat a wide range of
disease processes, and in which the priority aim is to ensure
sufficient plasma exchange to reduce or eliminate symptoms
resulting from the action of pathogenic elements vehiculised in the
plasma. Scientific selective apheresis with principles of
evidence-based medicine involves the application of one of the
oldest therapeutic modalities (bleeding), widely used between the
fourth century B.C. and the second industrial revolution. This book
provides information on the use of plasmapheresis during pregnancy;
therapeutic use of autologous plasma for the treatment of dry eye
disease; and therapeutic plasma exchange in the neurological
setting. It also discusses intravenous immunoglobulins. During the
past decades intravenous immunoglobulins (IVIG) have gained more
and more popularity for the treatment of a wide range of diseases
and conditions. This treatment is extensively used in immune
deficits, autoimmune thrombocytopenia, Kawasaki's disease, for the
prevention of infectious complications due to
hypogammaglobulinaemia secondary to myeloma, chronic lymphatic
leukaemia and post-bone marrow and stem cell transplantation, in
Guillain-Barre syndrome, etc. IV-Ig is obtained from the plasma of
healthy blood donors and contains normal, polyclonal, polyspecific
immunoglobins (Ig), mostly consisting of intact IgG. These
antibodies are directed against non-self-antigens, self-antigens
(natural autoantibodies), and other antibodies (idiotypic
antibodies). The administration of intravenous immunoglobulin
(IVIG) is generally safe and well tolerated. However, the treatment
of autoimmune disorders usually requires high dose therapy (1-2
g/kg) that may result in a greater frequency of side effects and
adverse events. This book discusses several topics including the
clinical application of intravenous immunoglobulins in autoimmune
mediated ocular inflammatory diseases; complications of intravenous
immunoglobulin therapy; clinical uses; and side effects.
General
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