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Books > Medicine > Clinical & internal medicine > Diseases & disorders > Oncology
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BRAF Targets in Melanoma - Biological Mechanisms, Resistance, and Drug Discovery (Hardcover, 2015 ed.)
Loot Price: R3,353
Discovery Miles 33 530
You Save: R648
(16%)
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BRAF Targets in Melanoma - Biological Mechanisms, Resistance, and Drug Discovery (Hardcover, 2015 ed.)
Series: Cancer Drug Discovery and Development, 82
Expected to ship within 12 - 17 working days
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Total price: R3,373
Discovery Miles: 33 730
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This volume contains a collection of writings from the leaders in
the fields of Molecular Biology and Melanoma Research which will
begin to tell the ever-expanding story of the most recent findings,
discoveries, and potential of BRAF-directed targets in melanoma.
Recent research has shown that BRAF inhibitors are effective for a
short period of time, but there is little hope that this drugs as
single agents will lead to durable benefit in a majority of
patients. Among scientists and researchers who work in drug
discovery, there is a lot of interest in the development of
molecularly targeted cancer agents. Namely, the identification of a
molecular target, the selection of molecules which effectively
inhibit this target. What is starkly different about the
development of this class of compounds, however, is that the
mechanism of action of these agents are not as straightforward as
was once previously assumed and the mechanisms of resistance that
tumor cells employ to evade complete destruction are unlike any
that have been described before. These discoveries in addition to
utilization of modern molecular biology techniques have led to a
series of hypotheses regarding which other types of molecules could
be used in combination with BRAF-inhibitors in hopes of
revolutionizing the potential of therapeutics in melanoma.
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