Seymour Glagov The last meeting, devoted exclusively to an
examination of the atherosclerotic plaque, took place in Chicago 25
years ago under the joint auspices of the Council on
Arteriosclerosis of the American Heart Association and the Chicago
Heart Association. The proceedings were published subsequently in a
volume entitled "Evolution of the Atherosclerotic Plaque", edited
by Richard J. Jones (1). Both experimental and human lesions were
considered and several provocative new approaches to the disorder
were discussed. The electron microscope was being applied
systematically to the study of blood vessels at that time, so that
details of the infrastructure and cellular composition of the
artery wall and of atherosclerotic lesions were presented in some
detail. There was, as one result of these explorations,
considerable discussion of morphologic evidence suggesting that the
principal cell involved in the atherogenic process was neither the
fibroblast nor the macrophage, as had been supposed, but the smooth
muscle cell. In particular, the findings indicated that this cell
could incorporate lipid and become a foam cell.
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