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Books > Medicine > Clinical & internal medicine > Endocrinology > Diabetes
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The Neurohypophysis - Physiological and Clinical Aspects (Paperback, Softcover reprint of the original 1st ed. 1984)
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The Neurohypophysis - Physiological and Clinical Aspects (Paperback, Softcover reprint of the original 1st ed. 1984)
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The elucidation of the structure, function, and clinical
significance of the neurohypophysis has been one of the most
rewarding chapters in the history of endocrinology. Diabetes
insipidus, which can be manifested by passage of 15 liters of urine
a day, is one of the most dramatic disorders of the endocrine
system, and can readily be managed by replacement therapy with the
natural secretions of this gland, or with synthetic analogues that
provide a more favorable therapeutic ratio. The neurohypophysis is
the archetypical neurosecretory gland. Its secretions arise within
well defined nerve cells in the hypothalamus, are transported by
axoplasmic flow to nerve endings in the neural lobe, are released
in response to propagated action potentials, and are regulated by
neurotransmitters and osmotic signals. This gland is a model for
homeostatic regulation; functional disorders of this regulation
lead to well defined disorders such as the syndrome of
inappropriate secretion of antidi uretic hormone (SIADH), which can
be mimicked by the ectopic secretion of its hormones by tumor
cells. These hormones were the first peptides to be sequenced and
synthesized chemically and their structure-function relations have
been characterized as well as those of any of the peptide hormones.
The concept that peptide hormones generally arise as products of
the processing of a larger prohormone precursor was first developed
from studies of the neurohypophysis. The concept of
stimulus-secretion coupling was first ap plied in neuronal tissue
to the neurohypophysis.
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