Unlike other narrowly focused books, Reactive Oxygen Species in
Biology and Human Health provides a comprehensive overview of ROS.
It covers the current status of research and provides pointers to
future research goals. Additionally, it authoritatively reviews the
impact of reactive oxygen species with respect to various human
diseases and discusses antioxidants and other compounds that
counteract oxidative stress. Comprised of seven sections, the first
section describes the introduction, detection, and production of
ROS, emphasizing phenolic compounds and vitamin E for their
abilities to act as antioxidants. This section also highlights the
role of lipoprotein-associated oxidative stress. Section two
addresses the importance of iron accumulation in the brain
resulting in the development of a group of neurodegenerative
disorders (NDs) and identifies several causative genes for
neurodegeneration with brain iron accumulation (NBIA) associated
with Parkinsonism-related disorders. The third section discusses a
number of NDs, including amyotrophic lateral sclerosis (ALS),
Alzheimer's disease (AD), Huntington's disease (HD), epilepsy, and
multiple sclerosis (MS). Section four addresses autoimmune diseases
caused by ROS, including asthma, autoimmune liver diseases,
rheumatoid arthritis, thyroid disease, primary biliary cirrhosis,
and systemic lupus. Section five analyzes a number of different
cancers, including lung cancer, breast cancer, and melanoma, along
with possible treatment regimens. Section six discusses
cardiovascular diseases (CVDs) induced by ROS, presents the
ROS-associated complex biochemical processes inducing inflammation
as an important cause of CVDs, and explains the roles carotenoids
play in preventing CVDs. The final section addresses other human
diseases induced by oxidative stress, including sickle cell
disease, nonalcoholic steatohepatitis, retinopathy, fibromyalgia,
chronic obstructive pulmonary disease, asthma, pulmonary
hypertension, infertility, and aging of human skin.
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