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Books > Science & Mathematics > Biology, life sciences > Cellular biology
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Protocols for Oligonucleotides and Analogs - Synthesis and Properties (Paperback, 1993 ed.)
Loot Price: R5,651
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Protocols for Oligonucleotides and Analogs - Synthesis and Properties (Paperback, 1993 ed.)
Series: Methods in Molecular Biology, 20
Expected to ship within 10 - 15 working days
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When first conceived, not only was the aim of Protocols for Oligo
nucleotides and Analogs to provide wide coverage of the ohgonuc-
otide chemistry field for readers who are well versed within the
field, but also to give investigators just entering into the field
a new perspective. The very first book on this topic was edited and
published by Michael Gait in 1984, in whose laboratory I
encountered the newer aspects of oligonucleotide chemistry. Since
then, oligonucleotide research has developed to such an extent that
its uses extend far beyond basic studies, and now find wide
application throughout clinical science as well. Until recently,
the major application of oligonucleotides has been in the area of
DNA-based diagnostic and "antisense oligonucleotid- based
therapeutic approaches. However, oligonucleotides are now also
being used as therapeutic agents and are thus frequently found in
clinical trials in humans. Synthesis of unmodified oligonucleotides
using automated synthe sizers has become a common practice in
numerous laboratories. How ever, improvements on the existing
techniques and the introduction of ever newer methods for
oligonucleotide synthesis is constantly driving ahead in the
leading research laboratories. And several new oligonucle otide
analogs have been synthesized and studied for their individual prop
erties in recent years. The present volume strives to bring the
readers the most up-to-date information on the newest aspects of
synthesis of oligo nucleotides and their analogs. A separate volume
covers synthesis of oligonucleotide conjugates, along with most of
the analytical techniques presently used for analysis of
oligonucleotides."
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