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A Guide to Cancer Genetics in Clinical Practice (Paperback)
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A Guide to Cancer Genetics in Clinical Practice (Paperback)
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Intensive research over the last fifteen years has yielded a vast
expansion in our understanding of the role of inheritance and
genetics in a variety of cancers. Several inherited conditions have
been identified which result in a high risk of various cancers;
some of these were previously recognised, but the genetic basis
underlying them has now been elucidated. This knowledge is now
entering the sphere of routine clinical care. Once the preserve of
researchers and highly specialised units, genetic testing for
cancer predisposition is now accessible to most clinicians via
regional genetics units; in the USA patients can access commercial
genetic testing facilities. There is a growing evidence base to
guide family screening and clinical management of affected
individuals. Surgeons, gastroenterologists, gynaecologists,
oncologists, endocrinologists and many others need an awareness of
these disorders, an understanding of genetic testing and when it is
indicated, and how to manage patients with inherited cancer
predisposition and their families. Testing for these conditions has
potential legal, ethical and financial implications different from
those which most clinicians regularly encounter, and continuing
scientific and clinical advance means that patients and their
doctors will face regular changes in management. This book covers
the basic concepts of cancer genetics. The common inherited cancer
syndromes are each dealt with in greater depth, with the current
management outlined. This book is aimed at all clinicians who may
encounter these conditions in their practice. It aims to facilitate
identification of high-risk individuals and families, to inform
interaction with geneticists and other sub-specialists, to provide
a basis for patient management and to stimulate interest in these
fascinating conditions.
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