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Dopamine - Glutamate Interactions in the Basal Ganglia (Paperback)
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Dopamine - Glutamate Interactions in the Basal Ganglia (Paperback)
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The basal ganglia are involved in complex brain functions, from
voluntary movement control to learning and reward processing, and
they are implicated in numerous neurological and psychiatric
disorders. Information from the cerebral cortex and thalamus is
conveyed to basal ganglia nuclei via glutamate release, while
dopamine from the midbrain is released in close proximity to
glutamate. At the heart of both function and dysfunction of basal
ganglia circuits is the interaction of these two neurotransmitters,
dopamine and glutamate. Elucidating the relationship between their
molecular and cellular effects and behavioural significance has
been challenging, but in the past 5-10 years, improved labeling,
imaging, recording, and genetic manipulation approaches have
yielded new information on how dopamine and glutamate interact to
generate the circuit activity underpinning basal ganglia function.
Dopamine-Glutamate Interactions in the Basal Ganglia synthesizes
this recent research from the level of receptor molecules all the
way to complex behaviours and disease. Current insights from
research on individual neurons and synapses, detailed circuit
analysis, and learning and action functions of the basal ganglia
are presented against a historical perspective. The book also
discusses compromised dopamine-glutamate interaction in disorders
of basal ganglia function, including Parkinson's disease,
Huntington's disease, and drug addiction.
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