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Books > Medicine > Clinical & internal medicine > Cardiovascular medicine
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Lipoprotein Metabolism and Atherogenesis (Hardcover)
Loot Price: R1,555
Discovery Miles 15 550
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Lipoprotein Metabolism and Atherogenesis (Hardcover)
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Atherosclerosis leading to coronary heart disease and to
cerebrovascular disorders is the number one cause of death in
industrialized societies. For the last two decades, great ad vances
have been made in understanding the pathogenesis of those
disorders. Recent studies have revealed that the earliest event in
atherogenesis is the adhesion of circulating leukocytes to the
vascular endothelial cells and their migration into the
subendothelial space. These cells are known to playa central role
in the formation of a fatty streak consist ing of lipid-laden foam
cells. As pathological events continue, the lesion is converted to
a more fibrous lesion associated with vascular smooth muscle cells.
To solve the enigma of this complicated process, intensive studies
in molecular biology have disclosed the genes involved in those
events. Some of the genes have been verified by creation of novel
animal models, which have led to novel therapeutic strategies for
subjects with atherosclerosis. This volume contains papers
presented at the International Symposium on Lipoprotein Metabolism
and Atherogenesis held in Kyoto December 5-8, 1998, supported in
part by the Japan Intractable Diseases Research Foundation. The
following three topics were the focus of the three-day program: I)
The molecular approach to studying risk factors and prevention 2)
The creation of novel animal models 3) Lipoprotein disorder as a
cause of activation of vascular endothelial cells Thirty
distinguished researchers from the United States, the United
Kingdom, Austria, Finland, Australia, and Japan were invited.
General
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