Targeted Genome Editing Using Site-Specific Nucleases - ZFNs, TALENs, and the CRISPR/Cas9 System (Hardcover, 2015 ed.)

This book serves as an introduction to targeted genome editing, beginning with the background of this rapidly developing field and methods for generation of engineered nucleases. Applications of genome editing tools are then described in detail, in iPS cells and diverse organisms such as mice, rats, marine invertebrates, fish, frogs, and plants. Tools that are mentioned include zinc finger nucleases (ZFNs), transcription activator-like effector nucleases (TALENs), and CRISPR/Cas9, all of which have received much attention in recent years as breakthrough technologies. Genome editing with engineered nucleases allows us to precisely change the target genome of living cells and is a powerful way to control functional genes. It is feasible in almost all organisms ranging from bacteria to plants and animals, as well as in cultured cells such as ES and iPS cells. Various genome modifications have proven successful, including gene knockout and knock-in experiments with targeting vectors and chromosomal editing. Genome editing technologies hold great promise for the future, for example in biomedical research, clinical medicine, and generation of crops and livestock with desirable traits. A wide range of readers will find this book interesting, and with its focus on applications in a variety of organisms and cells, the book will be valuable for life scientists in all fields.

General

Imprint:	Springer Verlag,Japan
Country of origin:	Japan
Release date:	2015
First published:	2015
Editors:	Takashi Yamamoto
Dimensions:	235 x 155 x 14mm (L x W x T)
Format:	Hardcover
Pages:	205
Edition:	2015 ed.
ISBN-13:	978-4-431-55226-0
Categories:	Books > Science & Mathematics > Biology, life sciences > Developmental biology Books > Science & Mathematics > Biology, life sciences > Cellular biology > General Books > Science & Mathematics > Biology, life sciences > Botany & plant sciences > General Books > Science & Mathematics > Biology, life sciences > Zoology & animal sciences > Animal reproduction Promotions
LSN:	4-431-55226-X
Barcode:	9784431552260

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