In Leukemia and Lymphoma: Detection of Minimal Residual Disease,
hands-on experts describe and discuss the minimal residual disease
(MRD) methods they have successfully pioneered for leukemias and
lymphomas. They apply reverse transcription PCR (RT-PCR) to acute
myeloid leukemia (AML), chronic myelogenous leukemia (CML), and
acute promyelocytic leukemia (APL). Other PCR methods are used for
Non-Hodgkin's Lymphoma and for the monitoring of follicular
lymphoma. Additional chapters address the use of real-time
quantitative PCR (RQ-PCR), the emergent method of choice, in
patients with acute lymphoblastic leukemia (ALL), the evaluation of
MRD techniques in clinical trials, and the application of flow
cytometry techniques.
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