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Prostaglandin and Lipid Metabolism in Radiation Injury (Paperback, 1987 ed.)
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Prostaglandin and Lipid Metabolism in Radiation Injury (Paperback, 1987 ed.)
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This volume contains the proceedings of the International
Conference on Prostaglandins and Lipid Metabolism in Radiation
Injury held in Rockville, Maryland, on October 2-3, 1986. Over 200
persons from eight countries attended the program, which consisted
of 24 oral presentations and 38 poster presentations. Forty-two of
those presentations have been included in this volume. The
conference was sponsored by the Armed Forces Radiobiology Research
Institute, located in Bethesda, Maryland. The effects of radiation
on lipid synthesis and membrane damage are aptly summarized in the
first five chapters. These chapters describe the effects of
radiation on lipid peroxidation of model membranes, and the role of
lipid composition in mammalian cell death and in bacterial radio-
and thermosensitivity. In bacteria, lipid peroxidation is not
essential for radiation-induced cell death. One of the key points
of the conference was the paradoxical nature of the radiobiology of
eicosanoids. On the one hand, eicosanoids are mediators of damage;
on the other, they are radioprotective agents. It is clear from the
literature and from the data presented at the conference that both
of these properties may also be observed as a consequence of
radiotherapy. Some studies indicate that nonsteroidal
anti-inflammatory drugs may minimize or prevent certain radiation
induced damage, but other studies show no positive effect."
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