Ligand Binding in the Transmembrane Region of Metabotropic Glutamate Receptors (Paperback)

Group I metabotropic glutamate receptors (mGluRs) play an important role in the treatment of numerous neurodegenerative, cognitive and psychiatric disorders. How can we identify exogenous ligands mediating the effects of mGluRs? How do these ligands affect the receptor? The author Tobias Noeske presents the establishment of strategies for the identification and optimization of molecules acting as non-competitive antagonists of group I mGluRs. These strategies ensure high diversity in the identified chemotypes not resembling original reference molecules ("scaffold-hopping"). The detection of new scaffolds, in turn, is divided into two approaches: First the development of pharmacological assays to screen compounds at a certain target for their bioactivity, and second the evaluation of computer aided methods for the identification of virtual hits to be screened on the pharmacological assays. Promising molecules were optimized regarding bioactivity and selectivity, their binding mode investigated and, finally, compared to existing lead compounds. This book addresses scientists in academia and industry working in early stage drug discovery, predominantly in computer aided drug design.

General

Imprint:	VDM Verlag Dr. Mueller E.K.
Country of origin:	Germany
Release date:	August 2007
First published:	August 2007
Authors:	Tobias Noeske
Dimensions:	244 x 170 x 11mm (L x W x T)
Format:	Paperback - Trade
Pages:	204
ISBN-13:	978-3-8364-2337-3
Categories:	Books > Medicine > Pre-clinical medicine: basic sciences > Medical genetics Books > Medicine > General issues > Medical equipment & techniques > Medical laboratory testing & techniques Promotions
LSN:	3-8364-2337-5
Barcode:	9783836423373

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