This issue of Clinics in Laboratory Medicine, Guest Edited by Dr. Anand S. Dighe, will focus on Clinical Decision Support, including tools, strategies, and emerging technologies. This issue is one of four issues selected per year by the series Consulting Editor, Milenko Jovan Tanasijevic. Topics include, but are not limited to, The Laboratory's Role in Clinical Decision Support, Integrating Decision Support into a Utilization Management Program, Decision Support Tools within the Electronic Health Record, Decision Support to Enhance Automated Testing and Laboratory Workflow, Laboratory-based CDS programs, Decision Support in Blood Banking, Decision Support in Molecular Pathology, A Computational Perspective on Decision Support, Emerging Decision Support Techniques, Decision Support and Patient Safety, Decision Support from a Reference laboratory perspective, and Training Aspects of Laboratory Based Decision Support.

The technique of in situ hybridization is now vital to molecular biologists and their understanding of the pathophysiology of cellular functions. This practical guide covers all aspects of in situ hybridization, describing: practical procedures and protocols; the scientific background; areas of application; and the limitations of the technology. This edition has been completely rewritten to take into acocunt the many advances in the seven years since its initial publication.

Self-assessment Q&A in Clinical Laboratory Science, III, adds a variety of subject matter that addresses new concepts and emerging technology, particularly in the areas of kidney biomarkers, cancer biomarkers, molecular diagnostics, multiple myeloma, pharmacogenomics, novel cardiovascular biomarkers and biomarkers of neurologic diseases. The field of Clinical Laboratory Science continues to evolve and editor Alan Wu has once again brought together experts in the field to cover the contemporary topics that are being tested today. This updated bank of questions and answers is a must-have to sharpen knowledge and skills.

Major advancements in the field of in situ molecular pathology have occurred since publication of the first edition. In Situ Molecular Pathology and Co-expression Analyses, Second Edition, continues to teach both the molecular basis for the improvements and the actual protocols. This is the unique feature that separates it from the pack of other "cook-book" type approaches. The fields of in situ hybridization and immunohistochemistry have expanded rapidly where computer-based analyses systems have greatly expanded the power of these methods. Further, knowledge of the marked improvements in the reagents themselves since the first edition can make the difference of excellent versus misleading data. The automated platforms require that researchers and diagnostic biomedical investigators have a good understanding of the basics of in situ based tests, protocols, and biochemistry for troubleshooting in order to maximize the use of these platforms. This second edition focuses attention on straightforward protocols used to simultaneously detect two or more proteins/nucleic acids within intact tissue by doing co-expression analyses. Practicing molecular pathologists, diagnostic pathologists, laboratory directors, and toxicologists, as well as clinicians and researchers in training, will benefit from this clear presentation of protocols and theoretical framework. Data derived from in situ hybridization and immunohistochemistry.

Genomics in the Clinic: A Practical Guide to Genetic Testing, Evaluation, and Counseling illustrates the current scope of the practice of genetics for healthcare professionals, so they can understand principles applicable to genetic testing and consultation. Written by an authoritative well-balanced team, including experienced clinical geneticists, genetic counselors, and medical subspecialists, this book adopts an accessible, easy-to-follow format. Sections are dedicated to basic genetic principles; clinical genetic and genomic testing; prenatal, clinical and cancer genetic diagnosis and counseling; and ethical and social implications in genomic medicine. Over 100 illustrative cases examine a range of prenatal, pediatric and adult genetic conditions and testing, putting these concepts and approaches into practice. Genomics in the Clinic: A Practical Guide to Genetic Testing, Evaluation, and Counseling is important for primary care providers, as patient care evolves in the current genomic-influenced world of precision medicine.

In this issue of Clinics in Laboratory Medicine, guest editor Dr. Fei Dong brings his considerable expertise to the topic of Molecular Oncology Diagnostics. Top experts in the field review current practices in molecular oncology diagnostics, highlighting the rapid clinical adoption of next generation sequencing techniques. The articles address key laboratory considerations in the molecular testing of cancer specimens and the impact of advanced testing strategies on patient care. Contains 15 practice-oriented topics including utility of single gene testing in cancer specimens; analytical principles of cancer next generation sequencing; principles and validation of bioinformatics pipelines for cancer next generation sequencing; panel sequencing for targeted therapy selection in solid tumors; and more. Provides in-depth clinical reviews on molecular oncology diagnostics, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

Advances in Molecular Pathology reviews the year's most important findings and updates within the field in order to provide molecular pathologists with the current clinical information they need to improve patient outcomes. A distinguished editorial board, led by Dr. Gregory Tsongalis, identifies key areas of major progress and controversy and invites preeminent specialists to contribute original articles devoted to these topics. These insightful overviews in molecular pathology inform and enhance clinical practice by bringing concepts to a clinical level and exploring their everyday impact on patient care. Provides in-depth, clinical reviews in molecular pathology, providing actionable insights for clinical practice. Presents the latest information in the field under the leadership of an experienced editorial team. Authors synthesize and distill the latest research and practice guidelines to create these timely topic-based reviews.

Translating microRNA to the Clinic reviews the possibilities of current methodological tools and experimental approaches used by leading translational researchers. The book features the uses of micro ribonucleic acid as deployed in cancer targeting in biomarkers, diabetes, cardiovascular disease, and neurodegeneration, among many others. Pedagogically, the work concentrates on the latest knowledge, laboratory techniques, and experimental approaches used by translational research leaders in this field, promoting a cross-disciplinary communication between the sub-specialities of medicine, but in common with other books on the topic. In addition, the book emphasizes recent innovations, critical barriers to progress, the new tools that are being used to overcome them, and specific areas of research that require additional study to advance the field as a whole.

Advances in Clinical Chemistry, Volume 77, the latest installment in this internationally acclaimed series, contains chapters authored by world-renowned clinical laboratory scientists, physicians, and research scientists. The serial discusses the latest and most up-to-date technologies related to the field of clinical chemistry and is the benchmark for novel analytical approaches in the clinical laboratory.

In this issue of Clinics in Laboratory Medicine, guest editors Drs. Christopher P. Holstege and Joshua D. King bring their considerable expertise to the topic of COVID-19 Molecular Testing and Clinical Correlates. Top experts in the field cover key topics such as point-of-care molecular assays for SARS-CoV-2; strategies for scaling up SARS-CoV-2 molecular testing capacity; cycle threshold values from SARS-CoV-2 PCR assays; and more. Contains 12 relevant, practice-oriented topics including analytic and clinical performance of major commercial SARS-CoV-2 PCR assays in the United States; isothermal assays for SARS-CoV-2 detection; rapid antigen assays for SARS-CoV-2; approaches to deployment of molecular testing for SARS-CoV-2 in resource-limited settings; and more. Provides in-depth clinical reviews on COVID-19 molecular testing and clinical correlates, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

Volume 69 in the internationally acclaimed Advances in Clinical Chemistry contains chapters authored by world renowned clinical laboratory scientists, physicians and research scientists. The serial provides the latest and most up-to-date technologies related to the field of Clinical Chemistry and is the benchmark for novel analytical approaches in the clinical laboratory.

"The Path from Biomarker Discovery to Regulatory Qualification "is a unique guide that focuses on biomarker qualification, its history and current regulatory settings in both the US and abroad. This multi-contributed book provides a detailed look at the next step to developing biomarkers for clinical use and covers overall concepts, challenges, strategies and solutions based on the experiences of regulatory authorities and scientists. Members of the regulatory, pharmaceutical and biomarker development communities will benefit the most from using this book-it is a complete and practical guide to biomarker qualification, providing valuable insight to an ever-evolving and important area of regulatory science.

For complimentary access to chapter 13, "'""Classic' Biomarkers of Liver Injury, " by John R. Senior, Associate Director for Science, Food and Drug Administration, Silver Spring, Maryland, USA, please visit the following site: http: //tinyurl.com/ClassicBiomarkers
Contains a collection of experiences of different groups taking different types of biomarkers to different levels of qualification and provides insightful case studies of an important area of regulatory science

Focuses on practical advice, concepts, strategies and overall outcomes to support those working toward biomarker qualification for clinical use

Offers a valuable resource for members of the regulatory, pharmaceutical and biomarker development communities. "

"Laboratory Animals: Regulations and Recommendations for Global Collaborative Research" is the only publication to offer a compilation of standards across the world in the care, welfare and use of animals in research. Timely in the new legislation in numerous regions of the world, this book provides the information in easily accessible, readable language.

For professionals across laboratory animal science and biomedical research, "Laboratory Animals: Regulations and Recommendations for Global Collaborative Research" provides a broad picture of the regulations required in other areas of the world and is essential to appropriately manage animal care and use programs.
Offers a worldwide view and global compilation of regulations, guidelines and recommendations for laboratory animal researchSaves valuable time researching different regional legislation and regulationsProvides insight into factors that play roles in the regulatory framework for countries and geographic regionsWritten in "layman s" terms to easily understand legislation and regulations"

In this issue of Clinics in Laboratory Medicine, guest editor Vinodh Pillai brings considerable expertise to the topic of pediatric hematopathology. Provides in-depth, clinical reviews on pediatric hematopathology, providing actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field; Authors synthesize and distill the latest research and practice guidelines to create these timely topic-based reviews.

Blood transfusion is a field where there have been, and continues to be, significant advances in science, technology and most particularly governance. This book aims to provide you with a comprehensive overview of both the scientific and managerial aspects of blood transfusion medicine. The book is intended to equip biomedical, clinical and allied medical professionals with practical tools to allow for an informed practice in the field of blood transfusion science. Dr. Erhabor Osaro 2013

The Common Marmoset in Captivity and Biomedical Research is the first text dedicated exclusively to this species,filling an urgent need for an encyclopedic compilation of the existing information. Sponsored by the American College of Laboratory Animal Medicine as part of its authoritative Blue Book series, the book covers the biology,management, diseases, and clinical and research applications of this important species. The common marmoset (Callithrix jacchus) has come of age in the scientific community as a behaviorally complex, cognitively advanced,small, prolific, and easily maintained nonhuman primate with many of the advantages of larger animals, such as macaques, but without the attendant physical and zoonotic risks. Marmosets are currently being used in diverse areas of inquiry, including vision and auditory research, infectious disease, cognitive neuroscience, behavior, reproductive biology, toxicology and drug development, and aging. The marmoset genome has been sequenced and there is currently an intensive effort to apply gene editing technologies to the species. The creation of transgenic marmosets will provide researchers with a small nonhuman primate model to study a number of poorly understood disorders, like autism.

This key title includes all the information contained in Part I of Linnes Clinical Laboratory Science: The Basics and Routine Techniques 4/eso that students do not have to buy the big volume if they are only interested in Part I of the book. It contains all the general background information necessary for working in a clinical laboratory and performing routine clinical laboratory tests. It covers the fundamentals of safety, collection of specimens, equipment, mathematics and measurements giving the student a thorough understanding of the basic concepts and background material which is an essential base in the practice of clinical laboratory science. * Prepares students for the realities of work in the clinical laboratory with an overview of the field of clinical laboratory science, and includes specifics on basic laboratory procedures. * Prepares the reader for the "real world" of the clinical laboratory with authors who have contributed years of research and experience in a frequently changing field and lend an "in the trenches" view of life to the modern clinical laboratory. * Offers the basic information about working in a clinical laboratory for introductory CLT/MLT or CLS/MT students. * Highlights clinical procedures by placing them in boxes that are easy for students to quickly find. * Chapter 1, Introduction to Clinical Laboratory Science, gives students a solid foundation on the fundamentals of clinical lab work. * Includes 59 illustrations to help explain the material and reinforce learning. * Includes Review Questions, Key Terms with definitions, Learning Objectives, Chapter Outlines, and Procedure Boxes, which provide excellent opportunities for group or individual study and reinforce the most important information in each chapter. * Includes a Glossary with key terms and definitions to help students with the new scientific terminology they will encounter in their initial clinical laboratory classes. * Includes an Instructors' Manual with student handouts, guides, exercises and related materials.

Temporal Sampling and Representation Updating, Volume 236, addresses the gap between laboratory studies using static or predictable stimuli and the more complex change that is a characteristic of the real world. Topics in this new volume include a section on Unfolding the time course of emotion perception, Temporal sampling and representation updating for action in interception and grasping tasks, The influence of Cognitive Control and Attention on Temporal Sampling: Lessons from the Attentional Blink, Synchronizing tracking eye movements with the motion of a visual target, and Sampling feature distributions with visual search in heterogeneous displays.