Volume 54 in the internationally acclaimed "Advances in Clinical Chemistry" contains chapters submitted from leading experts from academia and clinical laboratory science. Authors are from a diverse field of clinical chemistry disciplines and diagnostics, ranging from basic biochemical exploration to cutting-edge microarray technology.

Leading experts from academia and clinical laboratory science
Volume emphasizes novel laboratory advances with application to clinical laboratory diagnostics and practical basic science studies

Animal experiments have contributed much to our understanding of mechanisms of disease and are important for determining new therapies. This volume reviews the latest research and developments in this field.

* Discusses new discoveries, approaches, and ideas * Contributions from leading scholars and industry experts * Reference guide for researchers involved in molecular biology and related fields

Volume 47 in the internationally acclaimed Advances in Clinical Chemistry contains chapters submitted from leading experts from academia and clinical laboratory science. Authors are from a diverse field of clinical chemistry disciplines and diagnostics ranging from basic biochemical exploration to cutting-edge microarray technology.
Leading experts from academia and clinical laboratory science
Volume emphasizes novel laboratory advances with application to clinical laboratory diagnostics and practical basic science studies

Volume forty six in the internationally acclaimed Advances in Clinical Chemistry, contains chapters submitted from leading experts from academia and clinical laboratory science. Authors are from a diverse field of clinical chemistry disciplines and diagnostics ranging from basic biochemical exploration to cutting edge microarray technology.
* Leading experts from academia and clinical laboratory science
* Volume emphasizes novel laboratory advances with application not only to both clinical laboratory diagnostics, but as well as practical basic science studies

The Common Marmoset in Captivity and Biomedical Research is the first text dedicated exclusively to this species,filling an urgent need for an encyclopedic compilation of the existing information. Sponsored by the American College of Laboratory Animal Medicine as part of its authoritative Blue Book series, the book covers the biology,management, diseases, and clinical and research applications of this important species. The common marmoset (Callithrix jacchus) has come of age in the scientific community as a behaviorally complex, cognitively advanced,small, prolific, and easily maintained nonhuman primate with many of the advantages of larger animals, such as macaques, but without the attendant physical and zoonotic risks. Marmosets are currently being used in diverse areas of inquiry, including vision and auditory research, infectious disease, cognitive neuroscience, behavior, reproductive biology, toxicology and drug development, and aging. The marmoset genome has been sequenced and there is currently an intensive effort to apply gene editing technologies to the species. The creation of transgenic marmosets will provide researchers with a small nonhuman primate model to study a number of poorly understood disorders, like autism.

Here in a single source is a complete spectrum of ideas on the development of new anticancer drugs. Containing concise reviews of multidisciplinary fields of research, this book offers a wealth of ideas on current and future molecular targets for drug design, including signal transduction, the cell division cycle, and programmed cell death. Detailed descriptions of sources for new drugs and methods for testing and clinical trial design are also provided.
KEY FEATURES:
* One work that can be consulted for all aspects of anticancer drug development
* Concise reviews of research fields, combined with practical scientific detail, written by internationally respected experts
* A wealth of ideas on current and future molecular targets for drug design, including signal transduction, the cell division cycle, and programmed cell death
* Detailed descriptions of the sources of new anticancer drugs, including combinatorial chemistry, phage display, and natural products
* Discussion of how new drugs can be tested in preclinical systems, including the latest technology of robotic assay systems, cell culture, and experimental animal techniques
* Hundreds of references that allow the reader to access relevant scientific and medical literature
* Clear illustrations, some in color, that provide both understanding of the field and material for teaching

This key title includes all the information contained in Part I of Linnes Clinical Laboratory Science: The Basics and Routine Techniques 4/eso that students do not have to buy the big volume if they are only interested in Part I of the book. It contains all the general background information necessary for working in a clinical laboratory and performing routine clinical laboratory tests. It covers the fundamentals of safety, collection of specimens, equipment, mathematics and measurements giving the student a thorough understanding of the basic concepts and background material which is an essential base in the practice of clinical laboratory science. * Prepares students for the realities of work in the clinical laboratory with an overview of the field of clinical laboratory science, and includes specifics on basic laboratory procedures. * Prepares the reader for the "real world" of the clinical laboratory with authors who have contributed years of research and experience in a frequently changing field and lend an "in the trenches" view of life to the modern clinical laboratory. * Offers the basic information about working in a clinical laboratory for introductory CLT/MLT or CLS/MT students. * Highlights clinical procedures by placing them in boxes that are easy for students to quickly find. * Chapter 1, Introduction to Clinical Laboratory Science, gives students a solid foundation on the fundamentals of clinical lab work. * Includes 59 illustrations to help explain the material and reinforce learning. * Includes Review Questions, Key Terms with definitions, Learning Objectives, Chapter Outlines, and Procedure Boxes, which provide excellent opportunities for group or individual study and reinforce the most important information in each chapter. * Includes a Glossary with key terms and definitions to help students with the new scientific terminology they will encounter in their initial clinical laboratory classes. * Includes an Instructors' Manual with student handouts, guides, exercises and related materials.

Handbook of Animal Models of Infection is a complete revision of a three-volume text that was published in 1986. It incorporates the major advances in the field during the past decade, in particular those concerning molecular biological procedures and new models that have been developed. It focuses on both methods and techniques, which makes it an essential and comprehensive reference as well as a benchtop manual. The Handbook will help investigators save time and effort in formulating an approach to test a new potential therapeutic agent or combination of agents for "in vivo" efficacy and to position the therapy for specific infections where it may have therapeutic promise. The book is divided into five sections; the first covering the general methodologies, followed by sections describing experimental bacterial, mycotic, parasitic, and viral infections.
Key Features
* Discusses ethical and safety aspects in an introductory background section
* Covers principles of animal care and current techniques appropriate for the use of animal models of infection
* Details a wide range of animals including rodents, rabbits, cats, and primates
* Provides hands-on descriptions of how to set up the model
* Discusses the major advantages and limitations of each model
* Ensures full coverage of bacterial, fungal, viral, and parasitic infections

Temporal Sampling and Representation Updating, Volume 236, addresses the gap between laboratory studies using static or predictable stimuli and the more complex change that is a characteristic of the real world. Topics in this new volume include a section on Unfolding the time course of emotion perception, Temporal sampling and representation updating for action in interception and grasping tasks, The influence of Cognitive Control and Attention on Temporal Sampling: Lessons from the Attentional Blink, Synchronizing tracking eye movements with the motion of a visual target, and Sampling feature distributions with visual search in heterogeneous displays.

Advances in Clinical Chemistry, Volume 81, the latest installment in this internationally acclaimed series, contains chapters authored by world-renowned clinical laboratory scientists, physicians and research scientists. New to this latest release are chapters that cover Microparticles in Chronic Heart Failure, Peptide Antibodies in Clinical Laboratory Diagnostics, Measurement and Clinical Utility of ssCTX in Serum and Plasma, Human Papillomavirus and its Testing Assays, Cervical Cancer Screening, and Vaccination, and Physical Exercise and DNA Injury: Good or Evil? The serial presents the latest technologies related to the field of clinical chemistry, and is the benchmark for novel analytical approaches in the clinical laboratory.

"In Vitro" Methods in Pharmaceutical Research provides a comprehensive guide to laboratory techniques for evaluating "in vitro" organ toxicity using cellular models. Step-by-step practical tips on how to perform and interpret assays for drug metabolism and toxicity assessment are provided, along with a comparison of different techniques available. It is a welcome addition to the literature at a time when interest is growing in cellular "in vitro" models for toxicology and pharmacology studies.
Key Features
* Meets the continuing demand for information in this field
* Compares "In Vitro" techniques with other methods
* Describes cell-culture methods used to investigate toxicity in cells derived from different organs
* Includes contributions by leading experts in the field

This book provides basic, simple, and logical explanations for choices to be made to run the best Elispot possible. It allows the newcomer to truly understand the best options for specific protocol steps, reagents and materials, and provides even the experienced Elispot user with insight into best practices. The techniques presented here are supported by the author's twenty-plus years of first-hand experience working with this assay, as well as the shared experiences of numerous colleagues and collaborators. The enzyme-linked immunospot (Elispot) assay is a widely used technique to monitor cells on the single cell level for the release of analytes like cytokines, chemokines or immunoglobulins (antibodies), in response to particular stimuli. The most important feature of Elispot is its outstanding sensitivity, allowing the detection of specific cells in very low frequencies. The advantages of Elispot have resulted in it being widely adapted for use in research and translational applications in numerous fields including cancer, infectious diseases, autoimmunity, and transplantation.

Molecular diagnostic procedures have been described in a number of recent books and articles. However, these publications have not focused on virus detection, nor have they provided practical protocols for the newer molecular methods.
Written by the inventors or principal developers of these technologies, Molecular Methods for Virus Detection provides both reviews of individual methods and instructions for detecting virus nucleic acid sequences in clinical specimens. Each procedure includes quality assurance protocols that are often ignored by other methodology books. Molecular Methods for Virus Detection provides clinically relevant procedures for many of the newer diagnostic methodologies.
Key Features
* Provides state-of-the-art PCR methods for amplification, quantitation, " in situ" hybridization, and multiplex reactions
* Goes beyond PCR with protocols for 3SR, NASBA, LCR, SDA, and LAT
* Covers important virus detection methods such as "in situ" hybridization; Southern, dot, and slot blots; branched chain signal amplification; and chemiluminescence
* Includes quality control information crucial in research and clinical laboratories
* Most chapters are written by the inventors and principal developers of the methodologies
* Includes color plates, 77 figures, and 18 tables

The clinical laboratory is often known as a "black box" to nurses, physicians, and surgeons, but this concise book removes the veil by covering all the pertinent aspects of the clinical laboratory. This book bridges between medicine and chemistry by offering an overview to a clinical laboratory's structure and function, the importance of laboratory utilization and test ordering, as well as pre-analytical, analytical, and post-analytical issues of importance to recognize in any clinical laboratory. An interactive FAQ and a detailed index are also available.

This thesis describes novel substrate embedded physical sensors that can be used to monitor different types of cell-based assays non-invasively and label-free. The sensors described provide integrative information of the cells under study with an adaptable time resolution (ranging from milliseconds to days). This information about the dynamic cell response to chemical, physical or biological stimuli defines a new paradigm in fundamental biomedical research. The author, Maximilian Oberleitner, describes approaches in which the cells are directly grown on different sensor surfaces (gold-film electrodes, shear wave resonators or dye-doped polymer films). This approach, with the reacting cells in particularly close proximity and contact with the sensor surface, is key to a remarkable sensitivity, opening the way for a variety of new applications. This thesis not only introduces the fundamentals of each approach, but it also describes in great detail the design principles and elucidates the boundary conditions of the new sensors.

The Year Book of Pathology and Laboratory Medicine brings you abstracts of the articles that reported the year's breakthrough developments in pathology and laboratory medicine, carefully selected from more than 500 journals worldwide. Expert commentaries evaluate the clinical importance of each article and discuss its application to your practice. There's no faster or easier way to stay informed! Chapters in this annual cover the most current information on all aspects of pathology and laboratory medicine, including molecular diagnostics, anatomic pathology techniques, outcomes analysis, cytopathology, and clinical immunology and hematology.

Modeling Neuropsychiatric Disorders in Laboratory Animals serves as a guide for students and basic investigators in the fields of behavioral sciences, psychology, neuroscience, psychiatry, and other professionals interested in the use of animal models in preclinical research related to human neuropsychiatric disorders. The text focuses on the rationale and theory of using animal behavior, both pathological and normal, as a tool for understanding the neural underpinnings of neuropsychiatric disorders. Chapters contain discussions on both classical and modern views on the validation of animal models for neuropsychiatric disorders, also discussing the utility of endophenotypes in modeling neuropsychiatric disease. Subsequent chapters deal with four specific classes of disorders, including anxiety disorders, depressive disorders, obsessive-compulsive and related disorders. Final sections discuss the future for the development, validation, and use of animal models in basic and preclinical research.

Clinical laboratory directors and staff working with blood samples will benefit from the essential information in this hematology focused publication in Clinics in Laboratory Medicine. Leading a field of expert authors are two renown physicians in the field - Dr Carlo Brugnara and Dr Alexander Kratz. They present topics such as White Blood Cell Counts: Reference Methodology; Integration of Automated Heme and Bone Marrow Analysis; Red Cell Dynamics; Red Cell Diagnosis other than Anemia; Laboratory and Genetic Assessment of Iron Deficiency in Blood Donors; Body Fluid Cell Counting; Platelets: The Few, the Young, and the Active; Reticulocytes; Quality Control of Automated Cell Counters; Digital Image Analysis of Blood Cells; Blood Cell Counters in Urgent Care Settings; Novel Parameters in Blood Cell Counters; and the Development and Future of Automated Blood Cell Counters.

This expert volume covers an interdisciplinary and rapidly growing area of biomedical research comprising genetic, biochemical, pathological, and clinical studies aimed at the diagnosis and therapy of human diseases which are either caused by or associated with mitochondrial dysfunction. It dedicates itself to showcasing the tremendous efforts and the progress that has been made over the last decades in developing techniques and protocols for probing, imaging, and manipulating mitochondrial functions. Mitochondrial Medicine: Volume II, Manipulating Mitochondrial Function describes techniques developed for manipulating and assessing mitochondrial function under general pathological conditions and specific disease states. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Comprehensive and practical, Mitochondrial Medicine provides an essential source of know-how and inspiration to all researchers who are fascinated by this tiny organelle that seems so clearly to control the life and death of a single cell and whole organisms alike.

"Electrocardiography of Laboratory Animals" is the only book covering electrocardiography of laboratory animals, including dogs, mini-pigs, and cynomologus monkeys. As more countries institute requirements for the care of laboratory animals in research, this publication offers an effective standard on performing and analyzing ECGs. Topics covered include safety electrocardiography, toxicology, safety pharmacology, and telemetry. "Electrocardiography of Laboratory Animals" will assist biological and medical researchers, veterinarians, zoologists, and students in understanding electrocardiography of various species of animals used in research.
Covers safety electrocardiography of large laboratory animalsOffers comprehensive analysis of ECGs for practical laboratory useIncludes a self-evaluation section for testing of ECG reading and analysis

Written by authors representing the diverse field of clinical chemistry and diagnostics, reviews in Advances in Clinical Chemistry cover a range of cutting-eduge research ranging from basic biochemical exploration to microarray technology.
Written by authors representing the diverse field of clinical chemistry and diagnostics, reviews in Advances in Clinical Chemistry cover a range of cutting-eduge research ranging from basic biochemical exploration to microarray technology.

Biobanking, an emerging field supported by academia, industry and health administrators alike, is distinctly different today from the practice that once defined it. The science of Biobanking, which initially involved simply storing blood or tissue samples in a freezer, is now a highly sophisticated field of research, and expected to grow exponentially over the next decade or two. This book aims to serve the purpose of further enriching the available literature on Biobanking, by offering unique and more useful collection of ideas for the future. The book outlines the experiences of developing modern Biobanking repositories in different countries, whilst covering specific topics regarding the many aspects of Biobanking. This book will be of interest to a wide range of readers including: academics, students, volunteers and advocates of patients' rights.

Nonclinical Study Contracting and Monitoring: A Practical Guide offers a systematic and straightforward handbook for obtaining high quality preclinical Good Laboratory Practice (GLP) studies. This book is full of real-world examples, processes, procedures, useful templates, checklists and sample reports to provide readers with a better understanding of exactly what happens during all stages of a GLP study and the critical aspects of GLP study design and conduct. Designed for both the novice and experienced scientist, this book covers the GLP regulations and how they impact preclinical studies, the differences between GLP, non-GLP and peer-reviewed studies, preclinical GLP study design, laboratory selection, contracts and business ethics, how to obtain test material for the study, animal sourcing and release for study, preparation of a draft report and much more. By illustrating the overall big picture and tying it together with the individual steps, this book is an essential resource to help scientists ensure a high quality GLP study that passes both scientific and regulatory scrutiny.
Includes both the "big picture" look at complex processes, such as contracting toxicology and safety studies with CROs, as well as a detailed account of each individual step.

Contains several real world examples of problems in preclinical studies to provide you with an idea of the types of challenges that are routinely encountered and how this book can help you avoid these issues.

Provides monitoring checklists through the book that will help you comply with each GLP requirement and maintain compliance throughout the entire process.

Both entry level and experienced scientists involved in nonclinical toxicology study monitoring will benefit from the ideas, examples, discussions and strategies presented throughout this book.