The actions of honnones upon systems outside of the usual target
sites for such molecules represents an area of increasing interest
and growing clinical significance. This volume represents a
cross-section of such actions of honnones upon several relevant
sites. In the first chapter of this volume Dr. Malick discusses the
current status of endorphins as analgesic agents. It is now known
that a more primary level of control exists for iJ-endorphin in
that a 41-amino acid pep- tide has been isolated from ovine
hypothalamus; this peptide stimulates iJ-endorphin release as well
as the secretion of corticotropin (Vale et al. , 1981). The
analgesic properties of corticotropin and its immunoactive-like
analogs are well known. so it does not come as a surprise that
these two classes of analgesic peptides are regulated by a common
hypothalamic con- trol peptide. It may also be of interest to
observe that an increase in iJ-en- dorphin concentration in the
pituitary occurs in genetically obese mice and rats, and that such
obesity can be attenuated through the administration of nalaxone
(Margules et al. , 1978). It has also been determined that genet-
ically obese mice have a probable cholecystokinin deficiency in the
cerebral cortex in that this peptide is a satiety-inducing agent
(Saito, et al. , 1981). The analgesic properties of the latter have
also been observed. The extra-pituitary actions of another
pituitary peptide, as examined in the second chapter of this volume
by Dr.
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