Immunotoxin Methods and Protocols (Hardcover, 2001 ed.)

Immunotoxins represent a new class of human therapeutics that have widespread applications and a potential that has not yet been fully recognized since they were first conceived of by Paul Ehrlich in 1906. The majority of advances in the development and implementation of immunotoxins has occurred over the last 20 years. The reasons for this use of immunotoxins in basic science and clinical research are the powerful concurrent advances in genetic engineering and receptor physiology. Recombinant technology has allowed investigators to produce sufficient quantities of a homogeneous c- pound that allows clinical trials to be performed. The identification of specific receptors on malignant cell types has enabled scientists to generate immunotoxins that have had positive results in clinical trials. As more cellular targets are identified in coming years, additional trials will be conducted in different disease states affecting still larger patient populations. Modulation of the immune system to decrease the humoral response to immunotoxins may improve their overall efficacy. As increasingly more effective compounds are generated, it will be necessary to decrease the local and systemic toxicity - sociated with these agents, and methods for doing so are presently being - veloped. The work presented in Immunotoxin Methods and Protocols focuses on three specific areas of immunotoxin investigation that are being conducted by experts throughout the world. The first section describes the construction and development of a variety of immunotoxins.

General

Imprint:	HumanaPress
Country of origin:	United States
Series:	Methods in Molecular Biology, 166
Release date:	December 2000
First published:	2001
Editors:	Walter A Hall
Dimensions:	229 x 152 x 22mm (L x W x T)
Format:	Hardcover
Pages:	297
Edition:	2001 ed.
ISBN-13:	978-0-89603-775-5
Categories:	Books > Science & Mathematics > Biology, life sciences > Molecular biology
LSN:	0-89603-775-4
Barcode:	9780896037755

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