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Books > Medicine > Clinical & internal medicine > Diseases & disorders > Oncology
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Head and Neck Cancer - Basic and Clinical Aspects (Hardcover, 1995 ed.)
Loot Price: R8,907
Discovery Miles 89 070
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Head and Neck Cancer - Basic and Clinical Aspects (Hardcover, 1995 ed.)
Series: Cancer Treatment and Research, 74
Expected to ship within 10 - 15 working days
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Throughout the world, head and neck cancer is a major threat to
public health and a significant challenge to both clinicians and
basic scientists. Despite extensive efforts in primary prevention,
screening, early detection, and therapy, long-term survival rates
have not improved substantially in the last three decades. This
book covers a wide range of exciting new findings in both clinical
and basic sciences as they are relevant to head and neck cancer.
These findings have recently enhanced our understanding of head and
neck carcinogenesis at the genetic and molecular levels, offering
the promise of improved preventive and therapeutic strategies. The
book also presents information on the important clinical advances
that have been made in chemoprevention, organ preservation, and the
simultaneous use of chemotherapy and radiotherapy. The first
section provides an overview of the etiology and biology of head
and neck cancer, including an examination of human papillomaviruses
in both benign and malignant lesions. This section also discusses
the carcinogenic process at the genetic and molecular levels, as
well as aberrant squamous differentiation; increased understanding
of these areas has great potential to translate into new strategies
for cancer prevention. The second section describes recent advances
in developing a risk model for head and neck cancer, as well as the
application of genetic susceptibility data in chemoprevention. This
section also includes overviews of the status of chemoprevention
trials and of the process of invasion and metastasis in head and
neck cancer. The third section covers molecular studies of
radioresistance, early detection of head and neck cancer, and
theimplications of photodynamic therapy, while the fourth section
of the book includes studies of the timing and sequencing of
chemoradiotherapy. New strategies in this area have made a
significantly increased feasibility of laryngeal preservation in
the treatment of advanced laryngeal cancer. The fifth and last
section discusses the management of clinically negative neck
disease, the role of adjuvant therapy in preventing distant
metastasis, and new strategies for the treatment of recurrent
tumors. Finally, we close with some intriguing predictions for the
future of head and neck cancer therapy.
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