Since the awarding of the Nobel Prize to Drs. Guillemin and Schally
iJ) 1971 for isolation and chemical characterization of
gonadotropin releasing hormone, we have experienced a remarkable
period of growth of interest in this hormone. The last 20 years
have been characterized by a swift translation of basic science
discovery into clinical utility. Approval of GnRH and its analogs
for treatment of prostate cancer, endometriosis, of ovulation
indicate the range and precocious puberty and for induction of
these agents. of usefulness In order to bring together the leaders
in the basic and clinical science of GnRH, a conference was
organized on "Modes of Action of GnRH and GnRH Analogs" and held in
Scottsdale, Arizona, February 26 to March 2, 1991. The
presentations, given as chapters in this volume, show both the
advances in the body of information in this discipline and the
efforts underway to reduce basic science to clinical practice. The
audience was a combination of representatives from universities,
government, industry, and physicians in practice. The lively
discussions and insightful questions indicated the interest in the
topics discussed and frequently served to catalyze planned
interactions of the meeting participants. The organizers are
grateful to the speakers and poster presenters for their
contributions and for the timely preparations of the manuscripts
included in the present volume. We are also thankful to the staff
of Serono Symposia, USA, for the organizational skills and support
that allowed the meeting organizers to focus on the science and
medicine presented.
General
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