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Books > Medicine > Clinical & internal medicine > Diseases & disorders > Oncology
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Gene Therapy of Cancer - Methods and Protocols (Paperback, 2000 ed.)
Loot Price: R3,156
Discovery Miles 31 560
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Gene Therapy of Cancer - Methods and Protocols (Paperback, 2000 ed.)
Series: Methods in Molecular Medicine, 35
Expected to ship within 10 - 15 working days
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Since the discovery of the molecular structure of genes and the
unveiling of the molecular basis of numerous human diseases,
scientists have been fas- nated with the possibility of treating
certain diseases by transducing foreign DNA into the affected
cells. Initially, it was proposed that the foreign DNA could either
replace defective nonfunctional genes, or code for therapeutic
proteins. This concept has evolved into the rapidly growing field
of gene therapy. Even though surgery, radiotherapy, and
chemotherapy are widely ava- able and routinely used for cancer
treatment, these therapies fail to cure approximately 50 percent of
cancer patients. Therefore, since it is a disease characterized by
aberrant gene expression, cancer has been a target of gene therapy
research since the inception of this treatment modality. Numerous
cancer gene therapy strategies are currently being investigated,
including gene replacement therapy, the regulation of gene
expression to modulate immu- logical responses to tumors, the
direct killing of tumor cells, and direct int- ference with tumor
growth. In this context, gene transfer systems, tumor-specific
expression vectors, and novel therapeutic genes have been
extensively st- ied. All these strategies aim for the selective
destruction of human malignant disease while circumventing the
destruction of nonmalignant cells and tissues thereby minimizing
toxicity to the patient.
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