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A Roadmap to Nonhematopoietic Stem Cell-Based Therapeutics - From the Bench to the Clinic (Paperback)
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A Roadmap to Nonhematopoietic Stem Cell-Based Therapeutics - From the Bench to the Clinic (Paperback)
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A Roadmap to Non-hematopoietic Stem Cell-Based Therapeutics: From
the Bench to the Clinic is a resource that provides an overview of
the principles of stem cell therapy, the promises and challenges of
using stem cells for treating various clinical conditions, and
future perspectives. The overall goal is to facilitate the
translation of basic research on stem cells to clinical
applications. The properties of stem cells from various sources are
reviewed and the advantages and disadvantages of each for clinical
use are discussed. Modifying stem cell properties through
preconditioning strategies using physical, chemical, genetic, and
molecular manipulation to improve cell survival, increase cell
differentiation potential, enhance production of paracrine factors,
and facilitate homing to the site of injury or disease upon
transplantation are reviewed. Various routes of stem cell
administration and dosing, and the duration of effects, are
explored. Individual chapters are written by experts in the field
and focus on the use of stem cells in treating various degenerative
diseases, autoimmune diseases, wound healing, cardiovascular
disease, spinal cord injury, oral and dental diseases, and skeletal
disorders. Finally, experts in the regulatory arena discuss
mechanisms used in different countries for approving the use of
stem cells to treat diseases and many common issues that are
typically encountered while seeking approval for this class of
therapeutic agent.
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