Leading cancer researchers update and review the mechanisms of
action and the therapeutic selectivity and efficacy of 5-FU with
and without leucovorin and its prodrugs in the treatment of
colorectal cancer. Among the combination agents considered are
UFT/LV, 5-FU/EU, capecitabine (Xeloda), S-1, and a variety of
thymidylate synthase inhibitors. The authors discuss the potential
advantages and disadvantages of these varied drugs and their mode
of administration. Based on historical results with these agents
when used alone, they also present a rationale for their results
when used in combination with other agents.
General
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