Aquaporins summarizes the present knowledge in this expanding field of research, starting with the structural analysis of water channel proteins. Subsequent chapters begin with mammalian aquaporins, examining physiology and pathophysiology, analysis of knock-out model animals, and the regulation of aquaporin function. Also covered is the distribution and regulation of aquaporins in plants and the function of water and glycerol channels in microbial systems.
Key Features
* Comprehensive treatment of a topical research field
* Authored by world leaders in the field
* Covers structural biology and physiology
* Covers different experimental and biological systems
* Chapters on plant and microbial systems
* Extensive treatment of mammalian physiology and pathophysiology
* Structural analysis excellently illustrated

Distance learning and remote learning have been developing options within the eLearning and talent training realms for over two decades, yet distance learning has become a significant reality within the past few months, especially as the COVID-19 pandemic has forever impacted the K-12, higher education, and adult training and talent development workforce solutions. Within the rapid shift into remote and distance learning environments, the curricular design and instructional design are understood as necessary. However, there is a need to understand aspects around social learning within eLearning environments. It is important to understand the opportunity of moving towards transformative social learning environmental engagement and experiences within distance and remote learning environments to improve the ability to understand social learning in eLearning environments. eLearning Engagement in a Transformative Social Learning Environment focuses on supporting and enhancing remote and distance learning (eLearning) instructional experiences, discusses the strategic role of social learning within eLearning environments, and enhances levels of engagement, transformative learning, and talent attainment environments. This book provides insights and support towards policies and procedures within instructional and training decision making around social learning needs and support. The chapters will explore social learning opportunities and support, modeling social learning engagement, communities of practice, and instructional processes of eLearning. The intended audience is teachers, curriculum developers, instructional designers, professionals, researchers, practitioners, and students working in the field of teaching, training, and talent development.

The core idea underlying human rights is that everyone is inherently and equally worthy of respect as a person. The emergence of that idea has been one of the most significant international developments since the Second World War. But it is one thing to embrace something as an aspirational ideal and quite another to recognize it as enforceable law. The continued development of the international human rights regime brings a pressing question to the fore: What role should international human rights have as law within the American legal system? The U.S. Supreme Court and the Domestic Force of International Human Rights Law examines this question through the prism of the U.S. Supreme Court's handling of controversies bearing most closely on it. It shows that the specific disputes the Court has addressed can be best understood by recognizing how each interconnects with an overarching debate over the proper role to be accorded international human rights law within American institutions. By approaching the subject from the justices' standpoint, this book reveals a divide in the Court between two fundamentally different orientations toward the domestic impact of the international human rights regime.

DESCRIPTION:
Current Topics in Membranes provides a systematic, comprehensive, and rigorous approach to specific topics relevant to the study of cellular membranes. Each volume is a guest edited compendium of membrane biology. Articles in this volume discuss ion transport;
ocular aquaporins and aqueous humor dynamics;
the role of Ggap junction channels in the ciliary body secretory epithelium; regional dependence of inflow; functional modulators linking Iinflow with outflow of aqueous humor; aqueous humor outflow resistance; aqueous humor dynamics; the effects of circulatory events on
aqueous humor inflow and intraocular pressure; retinal ganglion cells and glaucoma; what functional genomics is teaching us about intraocular pressure regulation and glaucoma;
molecular approaches to glaucoma; outflow signaling mechanisms and new therapeutic strategies for the control of intraocular pressure.
*Guest edited by cell membrane experts
*Dynamic and thorough coverage of all aspects of the aqueous humor from inflow to outflow
*Provides the latest teachings on genomics and glaucoma
*Highlights new therapeutic strategies for the control of intraocular pressure

"Current Topics in Membranes" provides a systematic, comprehensive, and rigorous approach to specific topics relevant to the study of cellular membranes. Each volume is a guest edited compendium of membrane biology.
*Discusses the current stat of electrostatics in biomolecular simulations and future directions
*Includes information on time and length scales in lipid bilayer simulations
*Includes a chapter on the nature of lipid rafts

Membranes are essential cellular organelles. They not only define cells and other organelles, but also are critical in the cell function by selectively regulating the passage of molecules by acting as a matrix for other signaling molecules, and as conduits of information transfer between the external environment and the cell interior. This series was originally added in 1970 and has since provided a systematic, comprehensive, and rigorous approach to specific topics relevant to the study of cellular membranes. Each volume is a guest edited compendium of membrane biology. This series has been a mainstay for practicing scientists and students interested in this critical field of biology. Articles covered in the volume include The Mechanical Properties of Bilayers; Molecular Dynamic Modeling of MS Channels; Structures of the Prokaryotic Mechanosensitive; Channels MscL and MscS; 3.5 Billion Years of Mechanosensory Transduction: Structure and Function of Mechanosensitive Channels in Prokaryotes; Activation of Mechanosensitive Ion Channels by Forces Transmitted through Integrins and the Cytoskeleton; Thermodynamics of Mechanosensitivity; Flexoelectricity and Mechanotransduction; Lipid Effects on Mechanosensitive Channels; Functional Interactions of the Extracellular Matrix with Mechanosensitive Channels; MSCL: The Bacterial Mechanosensitive Channel of Large Conductance; The Bacterial Mechanosensitive Channel MscS: Emerging Principles of Gating and Modulation; Structure function relations of MscS; The MscS Cytoplasmic Domain and its Conformational Changes upon the Channel Gating; Microbial TRP Channels and Their Mechanosensitivity; MSCS-Like Proteins in Plants; Delivering Force and AmplifyingSignals in Plant Mechanosensing; MS Channels in Tip Growing Systems.

Current Topics in Membranes provides a systematic, comprehensive, and rigorous approach to specific topics relevant to the study of cellular membranes. Each volume is a guest edited compendium of membrane biology. This series has been a mainstay for practicing scientists and students interested in this critical field of biology. Articles covered in the volume include ENaC Proteins in Vascular Smooth Muscle Mechanotransduction; Regulation of the Mechano-Gated K2P Channel TREK-1 by Membrane Phospholipids; MechanoTRPs and TRPA1; TRPC; The Cytoskeletal Connection to Ion Channels as a Potential Mechanosensory Mechanism. Lessons From Polycystin-2 (TRPP2); Lipid Stress at Play: Mechanosensitivity of Voltage-Gated Channels; Hair Cell Mechanotransduction: The Dynamic Interplay between Structure and Function; Pharmacology of Hair Cell MS Channels; Hair Cell Mechanotransduction; Models of Hair Cell Mechanotrasduction; Touch; Mechanosensitive Ion Channels in Dystrophic Muscle; Mechanotransduction in Endothelial Cells;
MS Channels in Tumor Cell Migration; Mechanosensitive Channels in Regulating Smooth Muscle Contraction in the GI; Mechanosensitive Ion Channels in Blood-Pressure-Sensing Baroreceptor Neurons.

This volume in the "Current Topics in Membranes" series discusses the biology of chemokines and their binding partners, chemokine receptors, in normal and disease-related states. Chemokines are small proteins that are important in normal immune responses. Recent research demonstrates a role for these proteins in a variety of diseases such as heart disease, allergy, asthma, and cancer. As a result of the discovery of this link to disease, the topic of chemokines and drugs that block their actions has become an intense are of study. This book presents the topics of chemokines, chemokine receptors, and related pathologies in an integrated manner that provides the reader with a comprehensive and up-to-date knowledge of these topics.
* Provides a comprehensive overview of the history, molecular biology, cell biology, pharmacology, physiology, and pathophysiology of chemokines and their receptors
* Each chapter discusses "future directions and unanswered questions" of chemokine biology
* Serves as a road map for future research

There is a quiet revolution occurring in American public education policy. The debate surrounds the issue of how best to go about educating the country's youth in the modern--or postmodern--world. Simon looks beyond the debate to focus on what public school organization tells policymakers about outcomes.

Simon argues that public schools are open systems organizations, continually reacting to a changing environment and to evolving internal organizational conditions. The structure of public schools, he shows, has not changed dramatically, but the organizational priorities have and will continue to change. As he shows, public schools are complex mechanisms that cannot be easily manipulated to produce a quick fix to perceived problems. Through detailed case studies and their varied outcomes, Simon provides scholars, students, and public policy makers in education policy and administration with valuable insights into contemporary educational debates.

Sponsored by the American Real Estate Society (ARES), Indigenous Peoples and Real Estate Valuation addresses a wide variety of timely issues relating to property ownership, rights, and use, including: ancestral burial, historical record of occupancy, treaty implementation problems, eminent domain, the effects of large governmental change, financing projects under formal and informal title or deed document systems, exclusive ownership vs. non-exclusive use rights, public land ownership, tribal or family land claims, insurgency and war, legal systems of ownership, prior government expropriation of lands, moral obligation to indigenous peoples, colonial occupation, and common land leases. These issues can also be broadly grouped into topics, such as conflict between indigenous and western property rights, communal land ownership, land transfer by force, legacy issues related to past colonization and apartheid, and metaphysical/indigenous land value.

The book examines contemporary immigration policy and immigrant assimilation with a focus on the adoption of sanctuary ordinances in US local governments in connection with Latino in-migration. It also investigates the adoption of anti-immigrant settlement local ordinances in many local governments with particular focus on local law enforcement positions taken on enforcement of federal immigration laws. The book investigates a wide range of county-level characteristics of 3,000+ U.S. counties (e.g., socio-economic and demographic traits, political culture, social capital, religious denominations present, etc.) to identify correlates of pro- and anti-immigrant settlement. The book also features the analysis of a national survey and three targeted surveys in pro-immigration (San Francisco), divided (Maricopa), and anti-immigration (Tulsa) counties to explore the individual-level factors associated with sentiments on immigration policy. Finally, the book presents findings from two case studies where active encouragement of Latino settlement (Twin Falls, ID) and active opposition (Hazleton, PA) characterize local reaction to Latino in-migration. The mixed methods study leads the authors to conclude that a funnel of causality concept, path dependency, pro-social attitudes, and the concepts of moral panic and moral dialogue collectively lead to great insight into the question of why some communities are open and accepting while others are exclusionary.

The book examines contemporary immigration policy and immigrant assimilation with a focus on the adoption of sanctuary ordinances in US local governments in connection with Latino in-migration. It also investigates the adoption of anti-immigrant settlement local ordinances in many local governments with particular focus on local law enforcement positions taken on enforcement of federal immigration laws. The book investigates a wide range of county-level characteristics of 3,000+ U.S. counties (e.g., socio-economic and demographic traits, political culture, social capital, religious denominations present, etc.) to identify correlates of pro- and anti-immigrant settlement. The book also features the analysis of a national survey and three targeted surveys in pro-immigration (San Francisco), divided (Maricopa), and anti-immigration (Tulsa) counties to explore the individual-level factors associated with sentiments on immigration policy. Finally, the book presents findings from two case studies where active encouragement of Latino settlement (Twin Falls, ID) and active opposition (Hazleton, PD) characterize local reaction to Latino in-migration. The mixed methods study leads the authors to conclude that a funnel of causality concept, path dependency, pro-social attitudes, and the concepts of moral panic and moral dialogue collectively lead to great insight into the question of why some communities are open and accepting while others are exclusionary.

Mechanisms of Taste Transduction introduces a number of topics essential to a complete understanding of taste. These topics range from the control of food intake to the biophysical mechanisms of transduction and the design of food flavors in the food industry. The responses and organization of special sensory pathways are described in regard to their development, morphology, composition, electrophysiological and biochemical responses. Details are presented at several levels to appeal to researchers in molecular biology, membrane biophysics, human psychophysics, neuroanatomy, and chemistry. Current research is described in the context of what preceding studies have revealed, and the chapter authors are among today's most active and highly respected researchers in the field of chemical senses.

This book analyzes the energy security of the United States - its ability to obtain reliable, affordable, and sufficient supplies of energy while meeting the goals of achieving environmental sustainability and protecting national security. The economic and national security of the United States is largely dependent upon fossil fuels, especially oil. Without significant changes to current practices and patterns of energy production and use, the domestic and global impacts - security, economic, and environmental - are expected to become worse over the coming decades. Growing US and global energy demands need to be met and the anticipated impacts of climate change must be avoided - all at an affordable price, while avoiding conflict with other nations that have similar goals. Bernell and Simon examine the current and prospective landscape of American energy policy, from tax incentives and mandates at the federal and state level to promote wind and solar power, to support for fracking in the oil and natural gas industries, to foreign policies designed to ensure that markets and cooperative agreements - not armies, navies and rival governments - control the supply and price of energy resources. They look at the variety of energy related challenges facing the United States and argue that public policies designed to enhance energy security have at the same time produced greater insecurity in terms of fostering rising (and potentially unmet) energy needs, national security threats, economic vulnerability, and environmental dangers.

The purpose of this book is to publish the ideas of the late Herbert Simon and sympathetic economists, on the subject of bounded rationality, economics, cognitive science and related disciplines, and to reprint some of Professor Simon's classic papers which have appeared in journals not widely read by economists. Not only on account of his Nobel Prize in Economics, but also because of the widespread applications of his ideas and theories, it is especially valuable to readers to have a book of this kind at the present time. Currently in this whole field, there is increasing emphasis on computer-related theory building. Herbert Simon, beginning from the time when microcomputers did not exist, was a pioneer of this approach. The book begins with an edited transcript of a colloquium, held between Herbert Simon and a group of Italian economists in Italy in 1988. It continues with the reprinted Simon papers and papers by three scholars, Raymond Boudon, Massimo Egidi and Riccardo Viale coming from different disciplines but holding a common interest in bounded rationality and ends with a response by a sympathetic economist, Robin Marris.

Get yourself paid and broaden your skillset with this everyday guide to side hustles The gig economy is growing by leaps and bounds, partly because it's easier to find a flexible work-life balance. Those of us who don't want to leave our full-time jobs, however, can still grab a piece of excitement and extra income for ourselves by starting a side hustle. Or you can bundle your own personalized set of side hustles to replace your full-time job and take full control of your professional life. Whether you're thinking about driving for Uber, developing apps, or starting an online boutique, Side Hustles For Dummies walks you through every step of the way of starting your own side gig. You'll learn about how to structure your new business and keep records, create backup plans, and steer clear of scams. You'll also: Find out whether you need investment capital and learn what your new time commitments will be Learn to create a business plan and patch any holes in it before you get started Discover how to incorporate a vibrant side hustle into your already busy life Learn how to adjust your side hustle to meet changes in your personal life and the overall business climate Side hustles are for everyone, from high school and college students to full-time professionals to retirees. If you've been looking for an excuse to pursue your latest passion, hobby, or interest--or you're just in the market for some extra income--Side Hustles For Dummies is the easy-to-read, no-nonsense guide to creating a rewarding and engaging new life.

Written by world experts in the field of neuronal chemoreception, Methods in Chemosensory Research describes new molecular, electrophysiological, genetic, behavioral, psychophysical, and imaging techniques that have recently been adapted to investigate the basic neuronal mechanisms underlying chemoreception: taste, olfaction and chemical-induced irritation. This unique book includes a wide variety of new and innovative imaging methods, electrophysiological methods, methods to investigate development, and various aspects of behavioral testing.

Covering the entire spectrum of chemoreception, each section not only describes what information can be obtained by using each method, but also shows how to apply each method to obtain reliable results. The book presents a comprehensive view of how the brain uses information about chemical stimuli that interact with receptors in the nose and tongue. Methods in Chemosensory Research gives you the new tools to learn how chemicals affect activity from the genetic to the behavioral levels.

This book presents a comprehensive and coherent picture of how molecules diffuse across a liquid that is, on average, only two molecules thick. It begins by characterizing bilayers structurally, using X-ray diffraction, and then mechanically by measuring elastic moduli and mechanisms of failure. Emphasis is placed on the stability and mechanical properties of plant membranes that are subject to very large osmotic and thermal stresses. Using this information, the transport of molecules of increasing complexity across bilayers is analyzed.

Mechanisms of Taste Transduction introduces a number of topics essential to a complete understanding of taste. These topics range from the control of food intake to the biophysical mechanisms of transduction and the design of food flavors in the food industry. The responses and organization of special sensory pathways are described in regard to their development, morphology, composition, electrophysiological and biochemical responses. Details are presented at several levels to appeal to researchers in molecular biology, membrane biophysics, human psychophysics, neuroanatomy, and chemistry. Current research is described in the context of what preceding studies have revealed, and the chapter authors are among today's most active and highly respected researchers in the field of chemical senses.