This book brings together physicians, scientists and those concerned with the production and use of anti-inflammatory drugs to discuss basic issues affecting all aspects of side-effects, including their detection and treatment. The chapters cover a wide variety of topics including the epidemiology, clinical and experimental aspects of side-effects in the GI tract, liver, kidney, cartilage, bone and skin as well as the problems associated with the newer range of disease-modifying anti-rheumatic drugs such as methotrexate and cyclosporin. This book should be of interest to all those who develop and use anti-inflammatory analgesic drugs, from basic scientists to clinicians. It contains papers presented at the Third International meeting on "Side-Effects of Anti-inflammatory and Analgesic Drugs" held in Verona, Italy, 8-11 May 1991.

This book concerns the significance of the English Channel in British and French literature from the 1780s onwards: a timely subject given the intense debates in progress about the actual and desired relationships between Britain and mainland Europe. The book addresses contemporary authors who use the Channel as a focus for cultural comment, comparing their approaches to those of earlier writers, from Charlotte Smith and Chateaubriand through Hugo and Dickens to historians and travel writers of the 1950s and 1980s.

Dominic Rainsford examines ways in which literary texts may seem to comment on their authors' ethical status. Its argument develops through readings of Blake, Dickens, and Joyce, three authors who find especially vivid ways of casting doubt on their own moral authority, at the same time as they expose wider social ills. The book combines its interest in ethics with post-structuralist scepticism, and thus develops a type of radical humanism with applications far beyond the three authors immediately discussed.

Ibuprofen is widely used throughout the world for a variety of conditions. This reference work provides a comprehensive and critical review of the basic science and clinical aspects of the drug. The book begins with the history and development of the drug and its current patterns of use world- wide before moving on to examine its basic pharmaceutical attributes and medicinal chemistry. The properties of various formulations are described (oral prescription and OTC, topical and others) are described. The pharmacokinetics of ibuprofen in animals and humans is discussed - highlighting the factors affecting absorption, distribution, metabolism and elimination. The clinical pharmacology and toxicology and the drug's mechanisms of action in different disease states and conditions are covered. The therapeutic uses in various acute and inflammatory conditions is detailed. Also considered are the safety versus efficacy issues and the pharmacoepidemiological data.

Reviewing over a century of aspirin research and use, Aspirin and Related Drugs provides a comprehensive source of information on the history, chemistry, absorption in the body, therapeutic effects, toxicology, elimination, and future uses of aspirin. Highlighting the historical evolution of the salicylates and the commercial development of aspirin, the book reviews the pharmacokinetics of the salicylates, ibuprofen, and paracetamol as a basis for understanding the biodisposition of these analgesic drugs. Leading specialists discuss the therapeutic role of aspirin in the prevention and treatment of thrombo-embolic diseases, its place along with non-acetylated salicylates in the treatment of rheumatic diseases and plain, and the potential applications for aspirin and related drugs as prophylactics for colon cancer, Alzheimer's disease, and vascular dementia. They also present comparisons with other drugs used to treat pain and inflammation. With extensive data and literature covering a broad field, this is the definitive reference on the actions and applications of aspirin, salicylates, and related drugs. Physicians, pharmacists, pharmacologists, toxicologists, and chemists will find this resource useful in their daily work. It will also be valuable to pharmaceutical companies and researchers in the development of newer agents and novel applications.

Ibuprofen is widely used throughout the world for a variety of conditions. This reference work provides a comprehensive and critical review of the basic science and clinical aspects of the drug. The book begins with the history and development of the drug and its current patterns of use world- wide before moving on to examine its basic pharmaceutical attributes and medicinal chemistry. The properties of various formulations are described (oral prescription and OTC, topical and others) are described. The pharmacokinetics of ibuprofen in animals and humans is discussed - highlighting the factors affecting absorption, distribution, metabolism and elimination. The clinical pharmacology and toxicology and the drug's mechanisms of action in different disease states and conditions are covered. The therapeutic uses in various acute and inflammatory conditions is detailed. Also considered are the safety versus efficacy issues and the pharmacoepidemiological data.

This much anticipated volume critically reviews over a century of aspirin research and use. Providing a comprehensive source of information on the history, chemistry, absorption in the body, therapeutic effects, toxicology, elimination and future uses of aspirin, it is the most definitive reference currently available on this drug.
With chapters including the historical development of the salicylates and the commercial use of aspirin, this book also outlines the chemical properties and synthesis of aspirin, and its derivatives, developed over the last 100 years. Physicians, pharmacists, pharmacologists, toxicologists, chemists and other scientists will all find this book an invaluable insight into this popular and fascinating drug.

Providing a comprehensive and critical review of the basic science and clinical aspects of the drug, this book covers the history and development of the drug and its current patterns of use and examines its basic pharmaceutical attributes and medicinal chemistry. The author discusses the properties of various formulations and discusses the pharmacokinetics of ibuprofen in animals and humans--highlighting the factors affecting absorption, distribution, metabolism, and elimination. Topics include: the clinical pharmacology and toxicology and the drug's mechanisms of action in different disease states and conditions, the therapeutic uses in various acute and inflammatory conditions, and safety versus efficacy issues and the pharmacoepidemiological data.