Ibuprofen is widely used throughout the world for a variety of
conditions. This reference work provides a comprehensive and
critical review of the basic science and clinical aspects of the
drug. The book begins with the history and development of the drug
and its current patterns of use world- wide before moving on to
examine its basic pharmaceutical attributes and medicinal
chemistry. The properties of various formulations are described
(oral prescription and OTC, topical and others) are described. The
pharmacokinetics of ibuprofen in animals and humans is discussed -
highlighting the factors affecting absorption, distribution,
metabolism and elimination. The clinical pharmacology and
toxicology and the drug's mechanisms of action in different disease
states and conditions are covered. The therapeutic uses in various
acute and inflammatory conditions is detailed. Also considered are
the safety versus efficacy issues and the pharmacoepidemiological
data.
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