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This essential resource presents the most up-to-date information
on scleroderma. A clear and concise synthesis of current concepts
in pathogenesis and modern approaches to management, this book is
comprised of the authoritative work of international experts. With
an integrated multidisciplinary approach to comprehensive care,
this book iseasily accessible for health care professionals in many
fields. It is a valuable resource for rheumatologists,
pulmonologists, cardiologists, gastroenterologists, nephrologists
and all those involved in the care of scleroderma patients."
Leading investigators review the highlights of current fibrosis
research and the experimental methodologies used uncover the
mechanisms that drive it. In their discussion of research
methodologies utilizing cultured cells to model various aspects of
the fibrotic response in vitro, the authors describe the isolation,
characterization, and propagation of mesenchymal cells, and
highlight the similarities and differences between methods that are
appropriate for different types of fibroblasts. Approaches for
studying collagen gene regulation and TGF-b production are also
discussed, along with experimental methodologies utilizing animal
models to study the pathogenesis of fibrosis. The protocols follow
the successful Methods in Molecular Medicine(TM) series format,
each offering step-by-step laboratory instructions, an introduction
outlining the principles behind the technique, lists of the
necessary equipment and reagents, and tips on troubleshooting and
avoiding known pitfalls.
Comprised of the authoritative work of international experts, this
fully-updated second edition of Scleroderma builds upon the
well-regarded approach in the first edition to provide integrated,
concise, and up-to-date synthesis of current concepts of
pathogenesis and modern approaches to management of systemic
sclerosis (scleroderma). With a multidisciplinary approach to
comprehensive care, this book is easily accessible for health care
professionals in many fields. The new edition includes extensive
updated material based on major developments in the field, with new
chapters on personalized medicine, cancer complications, global
perspectives on scleroderma, and more. It presents a succinct and
thoughtful synthesis of current pathomechanistic concepts,
providing a valuable reference tool for basic and translational
investigators working in the field. Scleroderma: From Pathogenesis
to Comprehensive Management serves as an essential, all-inclusive
resource for rheumatologists, pulmonologists, cardiologists,
gastroenterologists, nephrologists and all those involved in the
care of scleroderma patients.
Leading investigators review the highlights of current fibrosis
research and the experimental methodologies used uncover the
mechanisms that drive it. In their discussion of research
methodologies utilizing cultured cells to model various aspects of
the fibrotic response in vitro, the authors describe the isolation,
characterization, and propagation of mesenchymal cells, and
highlight the similarities and differences between methods that are
appropriate for different types of fibroblasts. Approaches for
studying collagen gene regulation and TGF-b production are also
discussed, along with experimental methodologies utilizing animal
models to study the pathogenesis of fibrosis. The protocols follow
the successful Methods in Molecular Medicine (TM) series format,
each offering step-by-step laboratory instructions, an introduction
outlining the principles behind the technique, lists of the
necessary equipment and reagents, and tips on troubleshooting and
avoiding known pitfalls.
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