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Covering both the scientific basis of rheumatology and practical,
clinical information for rheumatologists and trainees,
Rheumatology, 8th Edition, remains a leading text in this
fast-changing field. Dr. Marc Hochberg and his team of worldwide
editors and authors keep you abreast of recent advances in the
field- all in a user-friendly, accessible manner. Fully updated
from cover to cover, this two-volume text is designed to meet the
needs of all practicing and academic rheumatologists as well as
arthritis-related health care professionals and scientists
interested in rheumatic and musculoskeletal diseases. Covers the
epidemiology, pathogenesis, clinical manifestations, therapeutic
approach, and management of all major as well as rarely encountered
rheumatic and musculoskeletal diseases. Discusses clinical
examination, imaging principles, differential diagnosis,
established and novel therapies, perioperative evaluation, pain
management, basic science, and genetics of rheumatic and
musculoskeletal diseases. Uses a consistent, logical,
reader-friendly format with templated chapters, concise text, and
large-scale, state-of-the-art illustrations for efficient visual
reference. Contains new chapters covering pre-clinical disease and
how to address these patients, common comorbidities in rheumatoid
arthritis; emerging therapies for systemic sclerosis; immune
mediated complications of checkpoint inhibitors; the epidemiology
of COVID-19 and rheumatic and musculoskeletal diseases, emerging
treatments for osteoarthritis, and big data analytics. Provides
updates to key topics such as systems biology and its impact on our
understanding of the pathogenesis of rheumatic and musculoskeletal
diseases, the microbiome in rheumatic musculoskeletal diseases, how
to manage chronic pain in the patient with a rheumatic disease,
drugs and reproductive health, and emerging therapies for patients
with RA, SLE, spondyloarthritis, inflammatory muscle disease, and
vasculitis. Shares the knowledge and expertise of numerous new
contributing authors, as well as new co-editor Dr. Desiree van der
Heijde, who is an expert in psoriatic arthritis, spondyloarthritis,
imaging, and clinical epidemiology. Provides access to concise
videos depicting the use of ultrasound for diagnosis and treatment.
Enhanced eBook version included with purchase. Your enhanced eBook
allows you to access all of the text, figures, and references from
the book on a variety of devices.
Many advances have occurred in the last 5 years especially in
understanding genetic susceptibility factors, the role of immune
response in chronic arthritis and the relationship between cellular
processes that underlie inflammation and tissue damage. All these
are dealt with in depth in the individual contributions. Genetics
studies included illustrate how studies of HLA genes and genes
controlling the autoantibody repertoire may be involved.
Environmental factors are believed to be important and studies both
in humans and in experimental models on the role of viral and
bacterial agents are covered. The fascinating relationship between
microbes, dysregulated immune responses and oncogenes are also
examined. Since autoimmunity is the key aspect of the immunological
response in rheumatoid arthritis, the role of antigens is
re-examined as is the part played by immune T and B cells. New
areas of clinical application of basic science is well presented in
this book, forexample, in examining how markers of cartilage
destruction may become important in monitoring disease activity. A
chapter reviewing possible future novel therapies is included.
More than 140 years ago, lupus erythematosus (LE) was recognized as
a disease entity by clinicians working in the field of dermatology,
which had only recently become an independent medical discipline.
Soon after cutaneous lupus was first reported, it was realized
that, apart from the skin, the disease could involve other organs
and thus be systemic in nature. The latter observations were first
made by MORITZ KApOSI [1], whose work has attracted renewed
attention re cently and who succeeded FERDINAND VON HEBRA to the
chair of dermatology at the Medical Faculty in Vienna. The early
description of lupus erythematosus in both its cutaneous and
systemic manifes tations was thus intimately associated with Vienna
and its Medical School. The next phase in the study of lupus was
characterized by an in crease in knowledge of the type and extent
of organ involvement. The work by OSLER [2], LIBMANN and SACKS [3],
and KLEMPERER [4] best represents these advances. The increase in
clinical knowledge of LE finally led to DUBOIS' famous monograph
[5], which was pub lished at a time of renewed interest in SLE,
elicited by the descrip tion by HARGRAVES et al. [6] of the LE-cell
phenomenon. A more detailed analysis of this finding revealed that
the disease was charac terized by an abnormal immune response,
although its pathogenetic implications were still unclear.
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