0
Your cart

Your cart is empty

Browse All Departments
  • All Departments
Price
  • R2,500 - R5,000 (2)
  • R5,000 - R10,000 (1)
  • -
Status
Brand

Showing 1 - 3 of 3 matches in All Departments

Transgenic Models in Endocrinology (Hardcover, 2001 ed.): Maria G. Castro Transgenic Models in Endocrinology (Hardcover, 2001 ed.)
Maria G. Castro
R4,385 Discovery Miles 43 850 Ships in 10 - 15 working days

The dramatic recent expansion in genomic information has motivated the development of new approaches to characterize gene expression and function. A critical issue for both basic and clinical endocrinologists is the physiological role of genes involved in regulating endocrine functions. Transgenic technologies allow the translation of genotypic information into specific phenotypes by using gene overexpression or loss of specific gene functions. Murine functional genomics is thus of central importance in modem biomedical endocrine research. Although mice are at present, the preferred mammalian species for genetic manipulations because of the availability of pluripotent embryonic. stem cells and inbred strains and the relatively low breeding and maintenance costs, transgenic rats have also been generated and used to study endocrine physiology. The two basic techniques used in the creation of transgenic animal models are integration of foreign DNA into a fertilized oocyte by random chromosomal insertion and homologous recombination in embryonic stem cells that are then introduced into zygotes. Transgenic mice and rats serve as sophisticted tools to probe protein function, as models of human disease, and as hosts for the testing of gene replacement and other therapies. Embryonic stem cell libraries for mouse gene deletion are being developed, which will make it possible to generate knockout mice rapidly and without the need to analyze gene structure, construct targeting vectors, and screen embryonic stem cell clones. A novel approach to transgenesis for the expression of DNA within adult differentiated neuroendocrine cells in vivo is using viral vectors.

Transgenic Models in Endocrinology (Paperback, Softcover reprint of the original 1st ed. 2001): Maria G. Castro Transgenic Models in Endocrinology (Paperback, Softcover reprint of the original 1st ed. 2001)
Maria G. Castro
R4,344 Discovery Miles 43 440 Ships in 10 - 15 working days

The dramatic recent expansion in genomic information has motivated the development of new approaches to characterize gene expression and function. A critical issue for both basic and clinical endocrinologists is the physiological role of genes involved in regulating endocrine functions. Transgenic technologies allow the translation of genotypic information into specific phenotypes by using gene overexpression or loss of specific gene functions. Murine functional genomics is thus of central importance in modem biomedical endocrine research. Although mice are at present, the preferred mammalian species for genetic manipulations because of the availability of pluripotent embryonic. stem cells and inbred strains and the relatively low breeding and maintenance costs, transgenic rats have also been generated and used to study endocrine physiology. The two basic techniques used in the creation of transgenic animal models are integration of foreign DNA into a fertilized oocyte by random chromosomal insertion and homologous recombination in embryonic stem cells that are then introduced into zygotes. Transgenic mice and rats serve as sophisticted tools to probe protein function, as models of human disease, and as hosts for the testing of gene replacement and other therapies. Embryonic stem cell libraries for mouse gene deletion are being developed, which will make it possible to generate knockout mice rapidly and without the need to analyze gene structure, construct targeting vectors, and screen embryonic stem cell clones. A novel approach to transgenesis for the expression of DNA within adult differentiated neuroendocrine cells in vivo is using viral vectors.

Gene Therapy for Neurological Disorders (Hardcover): Pedro R. Lowenstein, Maria G. Castro Gene Therapy for Neurological Disorders (Hardcover)
Pedro R. Lowenstein, Maria G. Castro
R5,401 Discovery Miles 54 010 Ships in 12 - 19 working days

Coedited by internationally recognized leaders in gene therapy research, this guide supplies the most recent advances, studies, and expert opinion on gene therapy for neurological disorders. Spanning conditions such as Parkinsons's and Alzheimer's disease, multiple sclerosis, brain tumors, stroke, epilepsy, and brain and spinal cord trauma, this reference presents the basic science and applications of recombinant gene products, immune and stem cell-mediated therapeutic strategies, and brain tumor gene therapy.

Free Delivery
Pinterest Twitter Facebook Google+
You may like...
Sandro Botticelli
Emile Gebhart Hardcover R992 Discovery Miles 9 920
Aquaporins, Volume 51
Dale J. Benos, Sidney A. Simon Hardcover R4,635 Discovery Miles 46 350
How I Got into Art School
Willy Smax Paperback  (1)
R328 Discovery Miles 3 280
The Cardiac Lymphatic System - An…
Ganga Karunamuni Hardcover R4,867 Discovery Miles 48 670
The Orchid Grower's Manual - Containing…
Benjamin Samuel Williams Paperback R448 Discovery Miles 4 480
Illustrations of the Book of Proverbs
William Arnot Paperback R638 Discovery Miles 6 380
Mancera Mancera Aoud Vanille Eau De…
R3,706 R3,427 Discovery Miles 34 270
Jobs For Development - Challenges and…
Gordon Betcherman, Martin Rama Hardcover R2,445 Discovery Miles 24 450
Lies mal Heft 3 - Das Heft mit der Robbe
Paperback R173 Discovery Miles 1 730
Evagrius Ponticus - The Making of a…
Julia Konstantinovsky Paperback R1,817 Discovery Miles 18 170

 

Partners