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Books > Medicine > Clinical & internal medicine > Endocrinology > Diabetes
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Transgenic Models in Endocrinology (Paperback, Softcover reprint of the original 1st ed. 2001)
Loot Price: R4,007
Discovery Miles 40 070
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Transgenic Models in Endocrinology (Paperback, Softcover reprint of the original 1st ed. 2001)
Series: Endocrine Updates, 13
Expected to ship within 18 - 22 working days
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The dramatic recent expansion in genomic information has motivated
the development of new approaches to characterize gene expression
and function. A critical issue for both basic and clinical
endocrinologists is the physiological role of genes involved in
regulating endocrine functions. Transgenic technologies allow the
translation of genotypic information into specific phenotypes by
using gene overexpression or loss of specific gene functions.
Murine functional genomics is thus of central importance in modem
biomedical endocrine research. Although mice are at present, the
preferred mammalian species for genetic manipulations because of
the availability of pluripotent embryonic. stem cells and inbred
strains and the relatively low breeding and maintenance costs,
transgenic rats have also been generated and used to study
endocrine physiology. The two basic techniques used in the creation
of transgenic animal models are integration of foreign DNA into a
fertilized oocyte by random chromosomal insertion and homologous
recombination in embryonic stem cells that are then introduced into
zygotes. Transgenic mice and rats serve as sophisticted tools to
probe protein function, as models of human disease, and as hosts
for the testing of gene replacement and other therapies. Embryonic
stem cell libraries for mouse gene deletion are being developed,
which will make it possible to generate knockout mice rapidly and
without the need to analyze gene structure, construct targeting
vectors, and screen embryonic stem cell clones. A novel approach to
transgenesis for the expression of DNA within adult differentiated
neuroendocrine cells in vivo is using viral vectors.
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