Focuses on the effects of natural products and their active components on brain function and neurodegenerative disease prevention. Phytochemicals such as alkaloids, terpenes, flavanoids, isoflavones, saponins etc are known to possess protective activity against many neurological diseases. The molecular mechanisms behind the curative effects rely mainly on the action of phytonutrients on distinct signaling pathways associated with protein folding and neuro-inflammation. The diverse array of bioactive nutrients present in these natural products plays a pivotal role in prevention and cure of various neurodegenerative diseases, disorders, or insults, such as Alzheimer's Disease, Parkinson's Disease, Huntington's Disease, traumatic brain injury, and other neuronal dysfunctions. However, the use of these antioxidants in the management of neurodegenerative conditions has so far been not well understood. This is a comprehensive collection addressing the effects on the brain of natural products and edible items such as reservatrol, curcumin, gingerol, fruits, vegetables, nuts, and marine products.

This book focuses on the principles, methods, and interpretation involved in establishing the safety, risk, and hazard assessment of small molecules. It presents the regulatory requirements for risk and hazard identification as per the guidelines of the Organization for Economic Cooperation and Development (OECD), Paris, and the International Council for Harmonisation (ICH) of Technical Requirements for Pharmaceuticals for Human Use ICH and Schedule 'Y', India. It serves as reference material for undergraduate and postgraduate pharmacy degree students as well as senior researchers to learn about the principles, methods, and interpretations of systemic dosage (acute and repeated dose) and genotoxicity (in vitro and in vivo), special toxicological investigations such as reproductive and developmental toxicology, carcinogenicity, and toxicokinetics using animal models or in vitro methods, as applicable. This book is the first of its kind in providing information on the principles and methods of implementation of Good Laboratory Practice based on the guidelines of OECD. It includes detailed chapters about the regulatory requirements and guidelines in pharmaceutical products and agrochemicals. It also describes the infrastructure needed for preclinical studies, including in vivo and in vitro facilities.

This book comprehensively reviews the proteins associated with neurodevelopmental disorders, including autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD). It also discusses the interactions of the associated-proteins, like bromodomain-containing proteins (BCPs), kinases, synaptic proteins, scaffolding proteins, transcriptional factors, and DNA-binding proteins at the subcellular and molecular levels. The book also explores the potential of these proteins as a druggable target and a biomarker in the neurodevelopmental disorders. The book further explores the recent advancements in understanding the important role of epigenetic factors in predisposition to these diseases. Lastly, it presents genetic factors that lead to variation in gene expression in these diseases, disorders management via diet intervention and the future potential of stem cell therapy.

This cutting-edge reference book discusses the intervention of artificial intelligence in the fields of drug development, modified drug delivery systems, pharmaceutical technology, and medical devices development. The comprehensive book includes an overview of Artificial intelligence in pharmaceutical sciences and applications in the drug discovery and development process. It discusses the role of machine learning in the automated detection and sorting of pharmaceutical formulations. It covers nanosafety, and the role of AI in predicting potential adverse biological effects. Key features – Includes lucid, step-by-step instructions to apply artificial intelligence and machine learning in pharmaceutical sciences Explores the application of artificial intelligence in nanosafety and prediction of potential hazards Covers application of artificial intelligence in drug discovery and drug development Reviews the role of artifical intelligence in assessment of pharmaceutical formulations Provides AI solutions for experts in pharmaceutical and medical devices industry The book is meant for academicians, students and industry experts in pharmaceutical sciences, medicine, and pharmacology.

This book discusses the role of nutrition in obsessive-compulsive disorders (OCD). It covers the investigational therapies in OCD, use of animal models, and biomarkers for better diagnosis, monitoring, and possible therapeutic options with nutrients for patients with OCD. The book highlights the role of probiotics, amino acids, vitamins, micro-nutrients, and salts in the management of OCD. It includes topics like the applications of computational modeling and nano-biotechnology in OCD, the effects of environmental pollutants, and the regulation of anti-depressants in OCD. Key features – Covers emerging therapeutic and nutritional approaches for the treatment and management of OCD Reviews the role of various micro-nutrients in OCD Discusses the prenatal genetic diagnosis and application of computational modelling in OCD Includes the nutritional and dietary roles in neuropsychiatric disorders like depression and obsessive-compulsive disorder (OCD) Explores the application of nano-biotechnology in OCD The book is meant for researchers and professionals in the field of nutritional neuroscience and psychology.

The book focuses on implications of traditional and processed foods for autism spectrum disorder (ASD) intervention and management. Numerous phytonutrients and pharmacologically active compounds in edible natural products and diet could influence and offer protection to neuronal dysfunction that occurs due to ASD. The neuroprotective effects of various fruits, vegetables, nuts and seeds phytochemicals, and other natural bioactive ingredients against ASD and related conditions are discussed. Topics such as the possible neuroprotective mechanism of action of these foods and the therapeutic role of antioxidants in relation to ASD are addressed. This book also highlights the scope of using anti-inflammatory agents and antioxidants to promote neurogenesis and improve other symptoms in ASD. It emphasizes personalized nutritional approaches with dietary management of neurodevelopmental disorders/ASD cases. Information in this book is relevant to researchers in the field of complementary and alternative medicine, nutraceuticals, neuroscience, agriculture, nutrition, and food science. This volume is beneficial to students of varying levels, and across multiple disciplines.

Of the many varieties of date palms, the species Phoenix dactylifera Linn. is cultivated extensively and traded and consumed worldwide. Dates: Production, Processing, Food, and Medicinal Values draws from a broad spectrum of contributors to present a comprehensive survey of this particular species. The book explores a range of essential facets of what many consider to be a wonder plant-from its cultivation to its potential for medicinal purposes.

Divided into four parts, the book begins by examining cultural practices and their implications for date quality. The contributors discuss tissue culture studies, farm water management, mechanization approaches in pollination and harvesting operations, and marketing aspects. The second section focuses on postharvest operations such as drying and explores alternatives for methyl bromide fumigation and value-added products. It also reviews biofuel production from by-products and discusses the issue of waste generated from industry.

The third part of the book highlights the physical, chemical, and structural characteristics of dates. It reviews fermentative products that use dates as substrate, discusses the fruits as a substitute for added sugar in food, and explores date palm feeding to livestock. The final section discusses the possibilities for nutritional and medicinal use and reviews the use of dates in indigenous medicine.

Exploring essential properties and agricultural implications, this volume is a reliable resource for understanding the many aspects of the Phoenix dactylifera Linn.

The book focuses on implications of traditional and processed foods for autism spectrum disorder (ASD) intervention and management. Numerous phytonutrients and pharmacologically active compounds in edible natural products and diet could influence and offer protection to neuronal dysfunction that occurs due to ASD. The neuroprotective effects of various fruits, vegetables, nuts and seeds phytochemicals, and other natural bioactive ingredients against ASD and related conditions are discussed. Topics such as the possible neuroprotective mechanism of action of these foods and the therapeutic role of antioxidants in relation to ASD are addressed. This book also highlights the scope of using anti-inflammatory agents and antioxidants to promote neurogenesis and improve other symptoms in ASD. It emphasizes personalized nutritional approaches with dietary management of neurodevelopmental disorders/ASD cases. Information in this book is relevant to researchers in the field of complementary and alternative medicine, nutraceuticals, neuroscience, agriculture, nutrition, and food science. This volume is beneficial to students of varying levels, and across multiple disciplines.

Focuses on the effects of natural products and their active components on brain function and neurodegenerative disease prevention. Phytochemicals such as alkaloids, terpenes, flavanoids, isoflavones, saponins etc are known to possess protective activity against many neurological diseases. The molecular mechanisms behind the curative effects rely mainly on the action of phytonutrients on distinct signaling pathways associated with protein folding and neuro-inflammation. The diverse array of bioactive nutrients present in these natural products plays a pivotal role in prevention and cure of various neurodegenerative diseases, disorders, or insults, such as Alzheimer's Disease, Parkinson's Disease, Huntington's Disease, traumatic brain injury, and other neuronal dysfunctions. However, the use of these antioxidants in the management of neurodegenerative conditions has so far been not well understood. This is a comprehensive collection addressing the effects on the brain of natural products and edible items such as reservatrol, curcumin, gingerol, fruits, vegetables, nuts, and marine products.

Nature has gifted mankind with a plethora of flora-bearing fruits, vegetables and nuts. The diverse array of bioactive nutrients present in these natural products plays a pivotal role in prevention and cure of various brain related or neurodegenerative diseases, such as Alzheimer's disease (AD), Parkinson's disease, ageing and other neuronal dysfunctions. Accumulated evidence suggests that naturally occurring phyto-compounds, such as polyphenolic antioxidants found in fruits, vegetables, herbs and nuts, may potentially protect neurodegeneration, and improve memory, cognition and other brain functions. The molecular mechanisms behind the curative effects may rely mainly on the action of phytonutrients on distinct signalling pathways associated with protein folding and neuroinflammation. The neuroprotective effects of food (fruits, vegetables and nuts) on brain related diseases are discussed in this book. This book has comprehensive collection of research studies that will benefit students at various levels, researchers in several disciplines (such as alternative medicine, nutrition, neuroscience, agriculture, food science and medicine) and many others interested in this discipline. The book also can be used as a required or recommended text for related courses taught at universities globally.

This book comprehensively reviews the proteins associated with neurodevelopmental disorders, including autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD). It also discusses the interactions of the associated-proteins, like bromodomain-containing proteins (BCPs), kinases, synaptic proteins, scaffolding proteins, transcriptional factors, and DNA-binding proteins at the subcellular and molecular levels. The book also explores the potential of these proteins as a druggable target and a biomarker in the neurodevelopmental disorders. The book further explores the recent advancements in understanding the important role of epigenetic factors in predisposition to these diseases. Lastly, it presents genetic factors that lead to variation in gene expression in these diseases, disorders management via diet intervention and the future potential of stem cell therapy.

Food and Huntingtons Disease is another book in a series of books related to the benefits of food on brain function. This book designates the possible beneficial effects of edible natural products and their active materials on Huntingtons disease. This is a progressive neurodegenerative disease that could cause uncontrolled movements, cognitive difficulties and emotional disturbances. The aim of this book and its series is to create awareness in general audiences about the dietary perception to reduce the occurrence of Huntingtons disease. This may enable a better understanding and possibly reduce the cost on medical bills for patients (approximately $4500/year/person) and the insurance companies. Literature revealed that this disturbing neurodegenerative disorder has a higher prevalence in Europe (3-7 in 100,000), North America (4-5 in 100,000), and Australia than in Asian countries. Studies suggest that mutation in the HD gene and the repeat expansion play an important role in the pathophysiology of this disease. The genetic defect underlying Huntingtons disease is unstable, caused by an abnormal CAG expansion within the first exon of the Huntingtin gene (HTT), leading to an expanded polyglutamine (polyQ) track in the HTT protein. This disease is an inherited one. Even though the prevalence rate is moderate, scientists predict that a lot of people possess the possibility of carrying this disease. Mitochondrial dysfunction and oxidative stress could very highly play a role in this disease. In the last decade, the benefits of food on many diseases including brain diseases were explored. This book aims to summarize the recent updates on the benefit of natural edible materials and their active principles on the prevention or delaying of the progression or the management of this disease. The editors feel highly obligated to all the contributors for this initiative. Undeniably, they believe that the information provided in this book would raise the awareness of the readers and could possibly help them to understand the disease process and the benefits of food items on Huntingtons disease management.

This book is intended for a diverse audience including football fans from various parts of the world visiting Qatar for the first time. It is estimated that at least one million people will visit Qatar during the FIFA World Cup 2022. We planned this book to be informative, insightful and holistic. The book covers highly relevant subjects to football, from sport infrastructure, elite athletes' performance, the sport's role in health, media, and climate, to sport enthusiast experience.

There is currently a growing body of evidence that supplementing the human diet with natural products is of major benefit for human health and well-being. Nowadays, the use of complementary or alternative medicine, functional food and especially the consumption of natural products, has been increasing rapidly world-wide, mostly because of their supposed less frequent side effects. Both in conventional and traditional medicines, food and natural products continue to provide valuable therapeutic agents. The issues regarding the efficacy and safety of currently available modern medicine agents have prompted the search for safer and more effective alternatives. This book contains a comprehensive collection of the beneficial features of fruits, vegetables, nuts and medicinal plants and herbs, against various diseases and how they should be utilised to obtain all their qualities and benefits.

It is well documented that most natural products are enriched with bio-active components that have protective action. There is currently a growing body of evidence that supplementing the human diet with natural products is of major benefit for human health and well-being. Nowadays, the use of complementary/alternative medicine, functional food and especially the consumption of natural products have been increasing rapidly world-wide, mostly because of the supposedly less frequent side effects. Both in conventional and traditional medicines, natural products continue to provide valuable therapeutic agents. The issues regarding the efficacy and safety of currently available modern medicine agents have prompted the search for safer and more effective alternatives. This book focuses on implications of traditional and processed foods for health and disease prevention.

Finding a simple and step-by-step procedure to conduct clinical biochemistry-related analyses is a real challenge for many undergraduate, graduate students, researchers and technicians in universities and laboratories. Moreover, understanding the theory of the experiment, which is not provided in some currently available manuals, is a useful and essential requirement in the experiment for successful performance, accuracy and acceptable results. The book contains 14 chapters. The first three chapters describe essential clinical aspects in laboratory such as specimens used for clinical chemistry analysis and sample collecting methods with common sampling errors. In addition, the fundamentals and laboratory techniques commonly used for sample analysis such as centrifugation, electrophoresis, photometry, fluorometry, and chromatography are also covered in one separate chapter. The later chapters discuss the biologic basics of liver, kidney and heart diseases and the common enzymes measured to assess the function of these organs. Moreover, properties, diagnosis and analysis of vital minerals disorders such as iron, calcium, phosphate, zinc and magnesium are discussed in five different chapters. Hematological disorders related to nutrition and some case histories and comments are added in order to help students to analyze and interpret the lab results in proper way. The book also has a separate chapter with lot of case studies and their solutions for better understanding. This book will be a useful reference for new students, non-native English medicine and life science students as it relies on figures and diagrams that explain the concepts and diagnosis of diseases in a simple way. Therefore, this quick guide aims to provide and develop the basic practical skills in the users with simple steps to follow along with the theoretical explanation for better understanding. It is expected that this quick handbook will provide good tools and useful guidelines for the students and researchers as well.