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This second edition provides 21 new chapters on methods used in
laboratories for investigating the physiology and molecular
genetics of the pathogen Clostridium difficile. Chapters detail
up-to -date experimental techniques for gene editing and
transcriptional analysis which are used to investigate the
fundamental biology of the organism and its virulence factors.
Additional chapters describe development of potential new
treatments including vaccines, bacteriophage and faecal
transplantation. Written in the highly successful Methods in
Molecular Biology series format, chapters include introductions to
their respective topics, lists of the necessary materials and
reagents, step-by-step, readily reproducible laboratory protocols,
and tips on troubleshooting and avoiding known pitfalls.
Authoritative and cutting-edge, Clostridium difficile: Methods and
Protocols, Second Edition provides a comprehensive catalogue of
molecular tools and techniques authored by the researchers who have
developed them.
Clostridium difficile, a major nosocomial pathogen shown to be a
primary cause of antibiotic-associated disease, has emerged as a
highly transmissible and frequently antibiotic-resistant organism,
causing a considerable burden on health care systems worldwide. In
Clostridium difficile: Methods and Protocols, expert researchers
bring together the most recently developed methods for studying the
organism, including techniques involving isolation, molecular
typing, genomics, genetic manipulation, and the use of animal
models. Written in the highly successful Methods in Molecular
Biology (TM) series format, chapters include brief introductions to
their respective topics, lists of the necessary materials and
reagents, step-by-step, readily reproducible laboratory protocols,
and notes highlighting tips on troubleshooting and avoiding known
pitfalls. Authoritative and cutting-edge, Clostridium difficile:
Methods and Protocols serves as an ideal guide for scientists now
in a position to gain an in-depth understanding of how this
organism is transmitted and how it causes disease.
This second edition provides 21 new chapters on methods used in
laboratories for investigating the physiology and molecular
genetics of the pathogen Clostridium difficile. Chapters detail
up-to -date experimental techniques for gene editing and
transcriptional analysis which are used to investigate the
fundamental biology of the organism and its virulence factors.
Additional chapters describe development of potential new
treatments including vaccines, bacteriophage and faecal
transplantation. Written in the highly successful Methods in
Molecular Biology series format, chapters include introductions to
their respective topics, lists of the necessary materials and
reagents, step-by-step, readily reproducible laboratory protocols,
and tips on troubleshooting and avoiding known pitfalls.
Authoritative and cutting-edge, Clostridium difficile: Methods and
Protocols, Second Edition provides a comprehensive catalogue of
molecular tools and techniques authored by the researchers who have
developed them.
Clostridium difficile, a major nosocomial pathogen shown to be a
primary cause of antibiotic-associated disease, has emerged as a
highly transmissible and frequently antibiotic-resistant organism,
causing a considerable burden on health care systems worldwide. In
Clostridium difficile: Methods and Protocols, expert researchers
bring together the most recently developed methods for studying the
organism, including techniques involving isolation, molecular
typing, genomics, genetic manipulation, and the use of animal
models. Written in the highly successful Methods in Molecular
Biology (TM) series format, chapters include brief introductions to
their respective topics, lists of the necessary materials and
reagents, step-by-step, readily reproducible laboratory protocols,
and notes highlighting tips on troubleshooting and avoiding known
pitfalls. Authoritative and cutting-edge, Clostridium difficile:
Methods and Protocols serves as an ideal guide for scientists now
in a position to gain an in-depth understanding of how this
organism is transmitted and how it causes disease.
This book provides an in-depth analysis of the mechanisms and
biological consequences of genome rearrangements in bacteria.
Genome rearrangements are a result of the actions of discrete
genetic elements such as conjugative transposons, plasmids, phage,
and non-conjugative transposons. Bacteria also contain systems to
mediate genetic rearrangements such as the general recombination
pathway and specialized endogenous recombination mechanisms. The
biological effects of these rearrangements are far-reaching and
impact on bacterial virulence, antibiotic resistance and the
ability of bacteria to avoid the attentions of the host immune
system (e.g. antigenic variation). These rearrangements also
provide the raw material on which natural selection can act. Each
chapter examines the mechanisms involved in genome rearrangements
and the direct biological consequences of these events. This book
is written by leading research workers and is an invaluable
resource for graduate students and researchers in this field.
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