This book provides an in-depth analysis of the mechanisms and
biological consequences of genome rearrangements in bacteria.
Genome rearrangements are a result of the actions of discrete
genetic elements such as conjugative transposons, plasmids, phage,
and non-conjugative transposons. Bacteria also contain systems to
mediate genetic rearrangements such as the general recombination
pathway and specialized endogenous recombination mechanisms. The
biological effects of these rearrangements are far-reaching and
impact on bacterial virulence, antibiotic resistance and the
ability of bacteria to avoid the attentions of the host immune
system (e.g. antigenic variation). These rearrangements also
provide the raw material on which natural selection can act. Each
chapter examines the mechanisms involved in genome rearrangements
and the direct biological consequences of these events. This book
is written by leading research workers and is an invaluable
resource for graduate students and researchers in this field.
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