Over the last several years the field of humanized mice has matured and developed into an essential component of translational research for HIV/AIDS. Humanized mice serve both as vehicles for discovery and as highly sophisticated platforms for biomedical research. In addition, humanized mice have demonstrated outstanding potential for the investigation of critical aspects of the infection and pathogenesis of the hepatitis and herpes viruses, as well as highly relevant microbial infections such as tuberculosis and malaria. Humanized Mice for HIV Research provides a comprehensive presentation of the history, evolution, applications, and current state of the art of this unique animal model. An expansion of twelve review articles that were published in Humanized Mice by Springer in 2008 (Eds: Nomura T, Watanabe T, Habu S), this book expertly captures the outstanding progress that has been made in the development, improvement, implementation, and validation of humanized mouse models. The first two parts of this book cover the basics of human-to-mouse xenotransplantation biology, and provide critical information about human immune cell development and function based on individual models created from different immunodeficient strains of mice. The third and fourth parts investigate HIV-1 biology, including different routes of transmission, prevention, treatment, pathogenesis, and the development of adaptive immunity in humanized mice. The fifth part shows the broad applicability of humanized mice for therapeutic development, from long-acting antiretroviral combinations to genetic manipulations with human cells and cell-based approaches. The sixth part includes liver tissue engineering and the expansion of humanized mice for many other human cell-tropic pathogens.

Proceedings of the First European Congress on Industrial Property Rights and Innovation

Rapid progress has been made in our understanding of the molecular mechanisms of cell growth and oncogenesis during the past decade. This book comprises recent results on the regulation of cell growth in normal and neoplastic tissues by growth factors including hormones, and by the activation and inactivation of oncogenes and tumor suppressor genes, respectively. Special attention has been given to the presentation of the frequently neglected close correlation between changes in signal transduction and metabolism pathways during oncogenesis.

Technology segregation is an ongoing practice within early childhood programs in the United States. This research, which includes two qualitative studies in the Northeast, reveals that school segregation and technology segregation are one in the same. Utilizing critical race theory, as the theoretical framework, this research finds that young Black children are denied technological access directly affecting their learning trajectories. PTO fundraising and other monetary donations to public schools vary by district and neighborhood and are based on segregation. Therefore, structural racism flourishes within these early childhood programs as black students are excluded from another important content area and practice. This book defines the problem of technology segregation in terms of policy, racial hierarchies, funding, residential segregation, and the digital divide. It challenges the racist framework and reveals disruptions (strategies) to counter this deficit discourse based on white supremacy.

In Anti-racist Pedagogy in the Early Childhood Classroom, author Miriam Tager provides detailed descriptions of Anti-Racist lessons and activities in early childhood classrooms. With accounts and examples from educators integrating anti-racist teachings into their classroom, this book explores what Anti-racist Pedagogy can look like and how these early childhood educators effectively utilize Anti-racist Pedagogy to combat racism within schools. The book also includes professional tips and advice for the higher education teacher to use in their teacher education programs to better prepare pre-service teachers for addressing issues on race and racism within their classrooms.

Challenging the normative paradigm that school readiness is a positive and necessary objective for all young children, this book asserts that the concept is a deficit-based practice that fosters the continuation of discriminatory classifications. Tager draws on findings of a qualitative study to reveal how the neoliberal agenda of school reform based on high-stakes testing sorts and labels children as non-ready, affecting their overall schooling careers. Tager reflects critically on the relationship between race and school readiness, showing how the resulting exclusionary measures perpetuate the marginalization of low-income Black children from an early age. Disrupting expected notions of readiness is imperative to ending practices of structural classism and racism in early childhood education.

Challenging the normative paradigm that school readiness is a positive and necessary objective for all young children, this book asserts that the concept is a deficit-based practice that fosters the continuation of discriminatory classifications. Tager draws on findings of a qualitative study to reveal how the neoliberal agenda of school reform based on high-stakes testing sorts and labels children as non-ready, affecting their overall schooling careers. Tager reflects critically on the relationship between race and school readiness, showing how the resulting exclusionary measures perpetuate the marginalization of low-income Black children from an early age. Disrupting expected notions of readiness is imperative to ending practices of structural classism and racism in early childhood education.

After decades of research most scholars generally agree that language acquisition is a complex and multifaceted process that involves the interaction of innate biologically-based mechanisms devoted to language, other non-linguistic cognitive and social mechanisms, linguistic input, and information about the social and physical world. Theoretical work in the field of language acquisition now needs to focus in greater depth and detail on some specific aspects of this general model, which is the main goal of this book. The chapters in this volume provide some new insights into one of the most remarkable accomplishments achieved by almost all children. The particular questions that are raised by contributors include: * What kinds of constraints operate on the process of language development? * Which aspects of the acquisition process depend on language-specific mechanisms? * Are there critical brain structures necessary for the acquisition of language? * What role do cognitive and social mechanisms play in language development? * How critical is perceptual input about the physical and social world? * What is the specific role played by linguistic input in the child's construction of a linguistic system? Questions are addressed from the perspective of children who come to the task of acquiring language with many hurdles to overcome, including deafness and blindness, mental retardation, autism, and prenatal or perinatal brain damage involving the left hemisphere. Each section contributes some insight on how an innate language-specific biological substrate interacts with cognitive and social factors, as well as external information, to support the child's construction of a linguistic system. Studies of atypical children offer a singular contribution to this enterprise by allowing us to see the specific influences of each component, and in turn, they shed new light on how all children are able to acquire language so effortlessly and during such a brief period of development.

After decades of research most scholars generally agree that language acquisition is a complex and multifaceted process that involves the interaction of innate biologically-based mechanisms devoted to language, other non-linguistic cognitive and social mechanisms, linguistic input, and information about the social and physical world. Theoretical work in the field of language acquisition now needs to focus in greater depth and detail on some specific aspects of this general model, which is the main goal of this book. The chapters in this volume provide some new insights into one of the most remarkable accomplishments achieved by almost all children.
The particular questions that are raised by contributors include:
* What kinds of constraints operate on the process of language development?
* Which aspects of the acquisition process depend on language-specific mechanisms?
* Are there critical brain structures necessary for the acquisition of language?
* What role do cognitive and social mechanisms play in language development?
* How critical is perceptual input about the physical and social world?
* What is the specific role played by linguistic input in the child's construction of a linguistic system?
Questions are addressed from the perspective of children who come to the task of acquiring language with many hurdles to overcome, including deafness and blindness, mental retardation, autism, and prenatal or perinatal brain damage involving the left hemisphere.
Each section contributes some insight on how an innate language-specific biological substrate interacts with cognitive and social factors, as well as external information, to support the child's construction of a linguistic system. Studies of atypical children offer a singular contribution to this enterprise by allowing us to see the specific influences of each component, and in turn, they shed new light on how all children are able to acquire language so effortlessly and during such a brief period of development.

Adenine Nucleotides play a major role in cellular metabolism and functions, serving as high-potential phosphate transfer compounds in energy metabolism and as substrates and co-factors for proteins involved in signal transduction. During the last few years definite advancement has been made in elucidating the molecular and genetic aspects of the enzyme involved in oxidative phosphorylation, the so-called FoFl H~-ATP synthase. Non-invasive NMR technologies have been developed to monitor in vivo the energy level of tissues based on determination of the concentrations of adenine nucleotides, phosphate and phosphate esters. Thus it became clear that the capacity of oxidative phosphorylation adapts itself to the ATP demand which changes continuously with the physiological state in various tissues. This is achieved by regulation of the enzyme activity as well as by regulation of its biogenesis. The reversible phosphorylation of proteins is re- cognised as a major regulatory mechanism in eukaryotic as well as in prokaryotic cells for cellular signal transduction and control of gene expression, cell growth, differentation and oncogenesis. The same applies to the role played by cAMP. A further topic of growing interest concerns the discovery of the ATP binding cassette (ABC) superfamily of transport proteins which includes systems of primary importance in medicine such as the multi-drug resistance P glycoprotein, the cystic fibrosis transmembrane conductance regulator (CFTR) and the 70 kd peroxisomal membrane protein. Finally, much attention is being devoted in many laboratories to the molecular structure and role of ATP- modulated channels.

Rapid progress has been made in our understanding of the molecular mechanisms of cell growth and oncogenesis during the past decade. This book comprises recent results on the regulation of cell growth in normal and neoplastic tissues by growth factors including hormones, and by the activation and inactivation of oncogenes and tumor suppressor genes, respectively. Special attention has been given to the presentation of the frequently neglected close correlation between changes in signal transduction and metabolism pathways during oncogenesis.

Every year, the Federation of European Biochemical Societies sponsors a series of Advanced Courses designed to acquaint postgraduate students and young postdoctoral fellows with theoretical and practical aspects of topics of current interest in biochemistry, particularly within areas in which significant advances are being made. This volume contains the Proceedings of FEBS Advanced Course No. 88-02 held in Bari, Italy on the topic "Organelles of Eukaryotic Cells: Molecular Structure and Interactions. " It was a deliberate decision of the organizers not to restrict FEBS Advanced Course 88-02 to a discussion of a single organelle or a single aspect but to cover a broad area. One of the objectives of the course was to compare different organelles in order to allow the participants to discern recurrent themes which would illustrate that a basic unity exists in spite of the diversity. A second objective of the course was to acquaint the participants with the latest experimental approaches being used by in vestigators to study different organelles; this would illustrate that methodologies developed for studying the biogenesis of the structure-function relationships in one organelle can often be applied fruitfully to investi gate such aspects in other organelles. A third objective was to impress upon the participants that a study of the interaction between different organelles is intrinsic to understanding their physiological functions. This volume is divided into five sections. Part I is entitled "Structure and Organization of Intracellular Organelles."

This book consists of a series of reviews on selected topics within the rapidly and vastly expanding field of membrane biology. Its aim is to highlight the most significant and important advances that have been made in recent years in understanding the structure, dynamics, and functions of cell membranes. The progress that is being made in research in this field is due to the application of integrated experimental ap- proaches, utilizing sophisticated and novel techniques in molecular biology, cell biology, biophysics and biochemistry. Due to the advances made, many problems have been or are being solved at the molecular level. With the help of an Editorial Advisory Board consisting of Jean-Pierre Changeux (Paris), Paolo Comoglio (Torino), Rainer Jaenicke (Regens- burg), Sten Orrenius (Stockholm), Lorenzo Pinna (Padova), Konrad Sandhoff (Bonn), and Gottfried Schatz (Basel), we have selected a number of topics in areas in which progress has been particularly rapid, and have invited internationally acknowledged experts in the field to review these topics. The areas covered in this monograph are: 1) Signal transduction; 2) Membrane traffic: Proteins and lipids; 3) Bioenergetics: Energy transfer and membrane transport; 4) Cellular ion homeostasis; 5) Growth factors and adhesion molecules; 6) Structural analysis of mem- brane proteins; and 7) Membranes and disease.

Membrane research holds a central position in cell and molecular biology. In recent years it has become clear that the study of membranes at the molecular level is of great importance not only to decipher all cellular processes but also to understand the alterations leading to abnormal cells (including cancer cells) and/or to understand the action of various drugs. This book covers the multidisciplinary approach of research in this area and the permanent need for information regarding recent advances. It will serve both workers studying basic aspects of membrane structure and function as well as medically oriented scientists. The selection of topics illustrating interconnections between basic and applied membrane biology will cross-fertilize research in both groups.

Technology segregation is an ongoing practice within early childhood programs in the United States. This research, which includes two qualitative studies in the Northeast, reveals that school segregation and technology segregation are one in the same. Utilizing critical race theory, as the theoretical framework, this research finds that young Black children are denied technological access directly affecting their learning trajectories. PTO fundraising and other monetary donations to public schools vary by district and neighborhood and are based on segregation. Therefore, structural racism flourishes within these early childhood programs as black students are excluded from another important content area and practice. This book defines the problem of technology segregation in terms of policy, racial hierarchies, funding, residential segregation, and the digital divide. It challenges the racist framework and reveals disruptions (strategies) to counter this deficit discourse based on white supremacy.

Over the last several years the field of humanized mice has matured and developed into an essential component of translational research for HIV/AIDS. Humanized mice serve both as vehicles for discovery and as highly sophisticated platforms for biomedical research. In addition, humanized mice have demonstrated outstanding potential for the investigation of critical aspects of the infection and pathogenesis of the hepatitis and herpes viruses, as well as highly relevant microbial infections such as tuberculosis and malaria. Humanized Mice for HIV Research provides a comprehensive presentation of the history, evolution, applications, and current state of the art of this unique animal model. An expansion of twelve review articles that were published in Humanized Mice by Springer in 2008 (Eds: Nomura T, Watanabe T, Habu S), this book expertly captures the outstanding progress that has been made in the development, improvement, implementation, and validation of humanized mouse models. The first two parts of this book cover the basics of human-to-mouse xenotransplantation biology, and provide critical information about human immune cell development and function based on individual models created from different immunodeficient strains of mice. The third and fourth parts investigate HIV-1 biology, including different routes of transmission, prevention, treatment, pathogenesis, and the development of adaptive immunity in humanized mice. The fifth part shows the broad applicability of humanized mice for therapeutic development, from long-acting antiretroviral combinations to genetic manipulations with human cells and cell-based approaches. The sixth part includes liver tissue engineering and the expansion of humanized mice for many other human cell-tropic pathogens.

A Contribution To The History Of The Political Reaction During The Last Years Of Russian Czarism.

A Contribution To The History Of The Political Reaction During The Last Years Of Russian Czarism.

We Americans may reside in the greatest nation on earth, but our lifestyle is killing us. Onequarter of us still smoke, two-thirds of us are fat, three-quarters of us don't exercise, and stress and depression are ubiquitous. We wolf down oversize portions of fast food in minutes and boast of not having taken a vacation in years. We get misinformation like "olive oil is healthy" but then get fatter because drizzling three tablespoons of oil on a salad adds as many calories as two scoops of premium ice cream. Despite all our advances in drugs and surgery, obesity and the diseases it causes have shortened life expectancy; this is the first time in history that children can expect to die younger than their parents.

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