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Books > Medicine > Clinical & internal medicine > Diseases & disorders > Immunology
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Humanized Mice for HIV Research (Hardcover, 2014 ed.)
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Humanized Mice for HIV Research (Hardcover, 2014 ed.)
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Over the last several years the field of humanized mice has matured
and developed into an essential component of translational research
for HIV/AIDS. Humanized mice serve both as vehicles for discovery
and as highly sophisticated platforms for biomedical research. In
addition, humanized mice have demonstrated outstanding potential
for the investigation of critical aspects of the infection and
pathogenesis of the hepatitis and herpes viruses, as well as highly
relevant microbial infections such as tuberculosis and malaria.
Humanized Mice for HIV Research provides a comprehensive
presentation of the history, evolution, applications, and current
state of the art of this unique animal model. An expansion of
twelve review articles that were published in Humanized Mice by
Springer in 2008 (Eds: Nomura T, Watanabe T, Habu S), this book
expertly captures the outstanding progress that has been made in
the development, improvement, implementation, and validation of
humanized mouse models. The first two parts of this book cover the
basics of human-to-mouse xenotransplantation biology, and provide
critical information about human immune cell development and
function based on individual models created from different
immunodeficient strains of mice. The third and fourth parts
investigate HIV-1 biology, including different routes of
transmission, prevention, treatment, pathogenesis, and the
development of adaptive immunity in humanized mice. The fifth part
shows the broad applicability of humanized mice for therapeutic
development, from long-acting antiretroviral combinations to
genetic manipulations with human cells and cell-based approaches.
The sixth part includes liver tissue engineering and the expansion
of humanized mice for many other human cell-tropic pathogens.
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