This volume focuses on mitochondrial RNA metabolism, emphasizing recent discoveries and technological advances in this fast moving area that increase our understanding of mitochondrial gene function. Topics addressed include the interplay of mitochondria with the nucleus and cytosol, structure-function connections, and relevance to human disease. Mitochondria are the powerhouses of the cell, and a great deal is known about mitochondrial energy metabolism. Less well known is the plethora of amazing mechanisms that have evolved to control expression of mitochondrial genomes. Several RNA processes and machineries in protozoa, plants, flies and humans are discussed, including: transcription and RNA polymerase mechanism; tRNA processing of 5' and 3' ends; mRNA maturation by nucleotide insertion/deletion editing and by RNA splicing; mRNA stability; and RNA import. Specialized factors and ribonucleoproteins (RNPs) examined include pentatricopeptide repeat (PPR) proteins, RNase P, polymerases, helicases, nucleases, editing and repair enzymes. Remarkable features of these processes and factors are either not found outside mitochondria, differ substantially among eukaryotic lineages, or are unique in biology.

The Class of This Year is a must read for everyone. You'll find the book is intentionally concise, down to earth, and easy to understand. As you move through the book, you'll come to understand the obstacles standing in the way, how to overcome those obstacles, and the power to move forward in your journey to success in life. Whether you've dropped out of school or completed the highest level of college, you will benefit from this program. Unfortunately, the information contained in the book is never taught in our public education system. From our point of view, it is far more important that any technical knowledge achieved. The Class of the Year will teach you how to succeed no matter what level of education you have.

2015 BMA Medical Book Awards Highly Commended in Oncology Category! The Molecular Basis of Cancer arms you with the latest knowledge and cutting-edge advances in the battle against cancer. This thoroughly revised, comprehensive oncology reference explores the scientific basis for our current understanding of malignant transformation and the pathogenesis and treatment of this disease. A team of leading experts thoroughly explains the molecular biologic principles that underlie the diagnostic tests and therapeutic interventions now being used in clinical trials and practice. Detailed descriptions of topics from molecular abnormalities in common cancers to new approaches for cancer therapy equip you to understand and apply the complexities of ongoing research in everyday clinical application. Effectively determine the course of malignancy and design appropriate treatment protocols by understanding the scientific underpinnings of cancer. Visually grasp and retain difficult concepts easily thanks to a user-friendly format with abundant full-color figures. Find critical information quickly with chapters following a logical sequence that moves from pathogenesis to therapy. Stay current with the latest discoveries in molecular and genomic research. Sweeping revisions throughout include eight brand-new chapters on: Tumor Suppressor Genes; Inflammation and Cancer; Cancer Systems Biology: The Future; Biomarkers Assessing Risk of Cancer; Understanding and Using Information About Cancer Genomes; The Technology of Analyzing Nucleic Acids in Cancer; Molecular Abnormalities in Kidney Cancer; and Molecular Pathology. Access the entire text and illustrations online, fully searchable, at Expert Consult.

Basic Confocal Microscopy, Second Edition builds on the successful first edition by keeping the same format and reflecting relevant changes and recent developments in this still-burgeoning field. This format is based on the Confocal Microscopy Workshop that has been taught by several of the authors for nearly 20 years and remains a popular workshop for gaining basic skills in confocal microscopy. While much of the information concerning fluorescence and confocal microscopy that made the first edition a success has not changed in the six years since the book was first published, confocal imaging is an evolving field and recent advances in detector technology, operating software, tissue preparation and clearing, image analysis, and more have been updated to reflect this. Several of these advances are now considered routine in many laboratories, and others such as super resolution techniques built on confocal technology are becoming widely available.

The debate on the origins of modern gender norms continues unabated across the academic disciplines. This book adds an important and hitherto neglected dimension. Focusing on rural life and its values, the author argues that the modern ideal of separate spheres originated in the era of the Enlightenment. Prior to the eighteenth century, cultural norms prescribed active, interdependent economic roles for both women and men. Enlightenment economists transformed these gender paradigms as they postulated a market exchange system directed exclusively by men. By the early nineteenth century, the emerging bourgeois value system affirmed the new civil society and the market place as exclusively male realms. These standards defined women's options largely as marriage and motherhood.

Quantification of the proliferative characteristics of normal and malignant cells has been of interest to oncolo gists and cancer biologists for almost three decades. This interest stems from (a) the fact that cancer is a disease of uncontrolled proliferation, (b) the finding that many of the commonly used anticancer agents are preferentially toxic to cells that are actively proliferating, and (c) the observa tion that significant differences in proliferation characteristics exist between normal and malignant cells. Initially, cell cycle analysis was pursued enthusiastically in the hope of gener ating information useful for the development of rational cancer therapy strategies; for example, by allowing identi fication of rapidly proliferating tumors against which cell cycle-specific agents could be used with maximum effec tiveness and by allowing rational scheduling of cell cyc- specific therapeutic agents to maximize the therapeutic ratio. Unfortunately, several difficulties have prevented realiza tion of the early promise of cell cycle analysis: Proliferative patterns of the normal and malignant tissues have been found to be substantially more complex than originally an ticipated, and synchronization of human tumors has proved remarkably difficult. Human tumors of the same type have proved highly variable, and the cytokinetic tools available for cell cycle analysis have been labor intensive, as well as somewhat subjective and in many cases inapplicable to humans. However, the potential for substantially improved cancer therapy remains if more accurate cytokinetic infor mation about human malignancies and normal tissues can be obtained in a timely fashion."

The debate on the origins of modern gender norms continues unabated across the academic disciplines. This book adds an important and hitherto neglected dimension. Focusing on rural life and its values, the author argues that the modern ideal of separate spheres originated in the era of the Enlightenment. Prior to the eighteenth century, cultural norms prescribed active, interdependent economic roles for both women and men. Enlightenment economists transformed these gender paradigms as they postulated a market exchange system directed exclusively by men. By the early nineteenth century, the emerging bourgeois value system affirmed the new civil society and the market place as exclusively male realms. These standards defined women's options largely as marriage and motherhood.

Peter Brent sat nervously smoking in the library of his great house, Brent Rock. He was a man of about forty-five or-six-a typical, shrewd business man. Something, however, was evidently on his mind, for, though he tried to conceal it, he lacked the self-assurance that was habitually his before the world. A scowl clouded his face as the door of the library was flung open and he heard voices in the hall. A tall, spare, long-haired man forced his way in, crushing his soft black hat in his hands.

This book shows how the fantasy tradition culminating in Pullman's "His Dark Materials" inherits the Romantic quest to transpose spiritual and moral values, once the prerogrative of organized religion, into new myths. Wary both of escapist fantasy and "grand narratives," it explores how stories can generate a new vision.

Co-Existing in a Globalized World: Key Themes in Inter-Professional Ethics brings together, and engages with, the scholarly work accomplished individually under the banner of professional ethics in various fields. The overarching theme of the volume is that globalization inevitably pairs professionals from distinct fields as co-workers. This necessitates serious reflection on how diverse fields can co-exist and achieve superior results through combining best practices from each. The authors are leading scholars and practitioners who have diverse national and distinguished professional backgrounds. These authors particularly focus on ethical concerns emerging from the inherent symbiotic relationship between cultural boundaries, professions and globalization. Furthermore, they put focused emphasis on ethical compliance with regard to globalization of professional practices into various cultural settings. The fields represented in the volume include international law, comparative education, East-West relations, engineering and bio-medical ethics, research ethics, and international professionalism in a cross-cultural context.

The expansion of Western education overseas has been both an economic success, if the rise in numbers of American, European, and Australian universities rushing to set up campuses in Asia and the Middle East is to serve as a measure, and a source of great consternation for academics concerned with norms of free inquiry and intellectual freedom. Faculty at Western campuses have resisted the opening of new satellite campuses, fearing that their colleagues those campuses would be less free to teach and engage in intellectual inquiry, and that students could be denied the free inquiry that is normally associated with liberal arts education. Critics point to the denial of visas to academics wishing to carry out research on foreign campuses, the sudden termination of employment at schools in both the Middle East and Asia, or the last-minute cancellation of courses at those schools, as evidence that they were correctly suspicious of the possibility that liberal arts programs could exist in those regions. Supporters of the project have argued that opening up foreign campuses would bring free inquiry to closed societies, improve educational opportunities for students who would otherwise be denied them, or, perhaps less frequently, that free inquiry will be no less pressured than in the United States or Western Europe. Normative Tensions examines the consequences not only of expansion overseas, but the increased opening of universities to foreign students.

Totalitarianism: The Basics is an easy to read introduction into the main concepts, ideologies, and regimes associated with totalitarianism. Starting with an overview of how scholars have attempted to define totalitarianism, Phillip W. Gray begins with an examination of the various types of terms used, helping the reader think about how these terms do - and do not - apply to different ideologies and governments. Easily accessible language and the use of numerous examples aids readers in seeing the connections between certain types of ideologies and some forms of organization/movements in their relation to historically well-known totalitarian regimes. Gray concludes with the tools necessary to think through how to distinguish between an actual (or potential) totalitarian system and regimes that, while oppressive or authoritarian, would not be totalitarian in nature. A rich bibliography containing additional readings bookend the text. Totalitarianism: The Basics offers an essential introduction for students from all backgrounds seeking to understand totalitarianism and for general readers with an interest in political ideologies and extremism. For those knowledgeable in this field, it adds conceptual relevance and the varieties of ways of thinking about the term.

The success of individual nation states today is often measured in terms of their ability to benefit from and contribute to a host of global economic, political, socio-cultural, technological, and educational networks. This increased multifaceted international inter-dependence represents an intuitively contradictory and an immensely complex situation. This scenario requires that national governments, whose primary responsibility is towards their citizenry, must relinquish a degree of control over state borders to constantly developing trans and multinational regimes and institutions. Once state borders become permeable all sorts of issues related to rights earned or accrued due to membership of a national community come into question. Given that neither individuals nor states can eschew the influence of the growing interdependence, this new milieu is often described in terms of shrinking of the world into a global village. This reshaping of the world requires us to broaden our horizons and re-evaluate the manner in which we theorize human personhood within communal boundaries. It also demands us to acknowledge that the relative decline of Euro-American economic and political influence and the rise of Asian and Latin American states at the global level have created spaces in which a de-territorialized and a de-historicized notion of citizenship and state can now be explored. The essays in this volume represent diverse disciplinary, analytical, and methodological approaches to understand what the implications are of being a citizen of both a nation state and the world simultaneously. In sum, Deconstructing Global Citizenship explores the question of whether a synthesis of contradictory national and global tendencies in the term "global citizenship" is even possible, or if we are better served by fundamentally reconsidering our ideas of "citizenship," "community," and "politics."

Liquid crystal science underlies the technology of about half the current display technology by value, an industry now worth some $10 billion per annum worldwide. The fundamental science straddles the disciplines of chemistry, physics, engineering, mathematics and computer science. Among liquid crystal scientists today there is much interest in the historical process that has brought the subject to its present level. The historical roots lie in the years following 1888, again in the interwar years, and finally in the late 60s and 70s. This book has collected important papers in the development of liquid crystal science into one reference volume. The collection is divided into sections, each of which is prefaced by a brief commentary, referring to the historic-scientific context of the time. Some of these papers are available for the first time in English. More modern papers carry a short commentary from the original author, offering recollections of the context in which the work was carried out and what its impact has been. Crystals that Flow is aimed at liquid crystal scientists- from whatever background- physics, mathematics, chemistry, engineering or computer science. Historians of science will also find this a useful reference.

The statement, "The Civil Rights Movement changed America," though true, has become something of a cliche. "Civil rights in the White Literary Imagination" seeks to determine how, exactly, the Civil Rights Movement changed the literary possibilities of four iconic American writers: Robert Penn Warren, Norman Mailer, Eudora Welty, and William Styron. Each of these writers published significant works prior to the "Brown v. Board of Education" case in 1954 and the Montgomery Bus Boycott that began in December of the following year, making it possible to trace their evolution in reaction to these events. The work these writers crafted in response to the upheaval of the day, from Warren's "Who Speaks for the Negro?," to Mailer's "The White Negro" to Welty's "Where Is the Voice Coming From?" to Styron's "Confessions of Nat Turner," reveal much about their own feeling in the moment even as they contribute to the national conversation that centered on race and democracy.

By examining these works closely, Gray posits the argument that these writers significantly shaped discourse on civil rights as the movement was occurring but did so in ways that--intentionally or not--often relied upon a notion of the relative innocence of the South with regard to racial affairs, and on a construct of African Americans as politically and/or culturally na*ve. As these writers grappled with race and the myth of southern nobility, their work developed in ways that were simultaneously sympathetic of, and condescending to, black intellectual thought occurring at the same time."

Given the widespread interest in macroscopic phenomena in liquid crystals, stemming from their applications in displays and devices, the need has arisen for a rigorous yet accessible text suitable for graduate students, whatever their scientific background. This book satisfies that need.
The approach taken in this text, is to introduce the basic continuum theory from nematic liquid crystals in equilibium, then it proceeds to simple application of this theory- in particular, there is a discussion of electric and magnetic field effects which give rise to Freedericksz transitions, which are important in devices. This is followed by an account of dynamic theory and elementary viscometry of nematics. Discussions of backflow and flow-induced instabilities are also included. Smetic theory is also briefly introduced, summarised, with with some examples of equilibrium solutions as well as dynamic effects. A number of mathematical techniques, such as Cartesian tensors and some variational calculus, are presented in the appendices.

Totalitarianism: The Basics is an easy to read introduction into the main concepts, ideologies, and regimes associated with totalitarianism. Starting with an overview of how scholars have attempted to define totalitarianism, Phillip W. Gray begins with an examination of the various types of terms used, helping the reader think about how these terms do - and do not - apply to different ideologies and governments. Easily accessible language and the use of numerous examples aids readers in seeing the connections between certain types of ideologies and some forms of organization/movements in their relation to historically well-known totalitarian regimes. Gray concludes with the tools necessary to think through how to distinguish between an actual (or potential) totalitarian system and regimes that, while oppressive or authoritarian, would not be totalitarian in nature. A rich bibliography containing additional readings bookend the text. Totalitarianism: The Basics offers an essential introduction for students from all backgrounds seeking to understand totalitarianism and for general readers with an interest in political ideologies and extremism. For those knowledgeable in this field, it adds conceptual relevance and the varieties of ways of thinking about the term.

This volume focuses on mitochondrial RNA metabolism, emphasizing recent discoveries and technological advances in this fast moving area that increase our understanding of mitochondrial gene function. Topics addressed include the interplay of mitochondria with the nucleus and cytosol, structure-function connections, and relevance to human disease. Mitochondria are the powerhouses of the cell, and a great deal is known about mitochondrial energy metabolism. Less well known is the plethora of amazing mechanisms that have evolved to control expression of mitochondrial genomes. Several RNA processes and machineries in protozoa, plants, flies and humans are discussed, including: transcription and RNA polymerase mechanism; tRNA processing of 5' and 3' ends; mRNA maturation by nucleotide insertion/deletion editing and by RNA splicing; mRNA stability; and RNA import. Specialized factors and ribonucleoproteins (RNPs) examined include pentatricopeptide repeat (PPR) proteins, RNase P, polymerases, helicases, nucleases, editing and repair enzymes. Remarkable features of these processes and factors are either not found outside mitochondria, differ substantially among eukaryotic lineages, or are unique in biology.