RNA Metabolism in Mitochondria (Paperback, Softcover reprint of the original 1st ed. 2018)

This volume focuses on mitochondrial RNA metabolism, emphasizing recent discoveries and technological advances in this fast moving area that increase our understanding of mitochondrial gene function. Topics addressed include the interplay of mitochondria with the nucleus and cytosol, structure-function connections, and relevance to human disease. Mitochondria are the powerhouses of the cell, and a great deal is known about mitochondrial energy metabolism. Less well known is the plethora of amazing mechanisms that have evolved to control expression of mitochondrial genomes. Several RNA processes and machineries in protozoa, plants, flies and humans are discussed, including: transcription and RNA polymerase mechanism; tRNA processing of 5' and 3' ends; mRNA maturation by nucleotide insertion/deletion editing and by RNA splicing; mRNA stability; and RNA import. Specialized factors and ribonucleoproteins (RNPs) examined include pentatricopeptide repeat (PPR) proteins, RNase P, polymerases, helicases, nucleases, editing and repair enzymes. Remarkable features of these processes and factors are either not found outside mitochondria, differ substantially among eukaryotic lineages, or are unique in biology.

General

Imprint:	Springer Nature Switzerland AG
Country of origin:	Switzerland
Series:	Nucleic Acids and Molecular Biology, 34
Release date:	February 2019
First published:	2018
Editors:	Jorge Cruz-Reyes • Michael W. Gray
Dimensions:	235 x 155 x 14mm (L x W x T)
Format:	Paperback
Pages:	249
Edition:	Softcover reprint of the original 1st ed. 2018
ISBN-13:	978-3-03-008637-4
Categories:	Books > Medicine > Pre-clinical medicine: basic sciences > Medical genetics Books > Science & Mathematics > Biology, life sciences > Biochemistry > General Books > Science & Mathematics > Biology, life sciences > Microbiology (non-medical) > General
LSN:	3-03-008637-2
Barcode:	9783030086374

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