Without much fanfare Ahmed Kathrada worked alongside Nelson Mandela, Walter Sisulu and other giants in the struggle to end racial discrimination in South Africa. He faced house arrest and many court trials related to his activism until, finally, a trial for sabotage saw him sentenced to life imprisonment alongside Mandela and six others.

Conversations with a Gentle Soul has its origins in a series of discussions between Kathrada and Sahm Venter about his opinions, encounters and experiences. Throughout his life, Kathrada has refused to hang on to negative emotions such as hatred and bitterness. Instead, he radiates contentment and the openness of a man at peace with himself. His wisdom is packaged within layers of optimism, mischievousness and humour, and he provides insights that are of value to all South Africans.

What is more profitable than cocaine, heroin, marijuana or guns? Illegally trafficked cigarettes . . .

Reputable tobacco companies have – for decades – been complicit in cigarette smuggling. In this gripping exposé, former SARS lawyer Telita Snyckers uncovers the dark underbelly of the tobacco industry.

She recounts the instances where big tobacco itself was caught redhanded and explores not only why a listed company would want to smuggle its own product, but also how it was done.

"He either enchants or antagonizes everyone he meets. But even his enemies agree there are three things Ray Kroc does damned well: sell hamburgers, make money, and tell stories." --from Grinding It Out

Few entrepreneurs can claim to have radically changed the way we live, and Ray Kroc is one of them. His revolutions in food-service automation, franchising, shared national training, and advertising have earned him a place beside the men and women who have founded not only businesses, but entire empires. But even more interesting than Ray Kroc the business man is Ray Kroc the man. Not your typical self-made tycoon, Kroc was fifty-two years old when he opened his first franchise. In Grinding It Out, you'll meet the man behind McDonald's, one of the largest fast-food corporations in the world with over 32,000 stores around the globe.

Irrepressible enthusiast, intuitive people person, and born storyteller, Kroc will fascinate and inspire you on every page.

The gripping and shocking story of three generations of the Sackler family and their roles in the stories of Valium and Oxycontin, by the prize-winning, bestselling author of Say Nothing.

The Sackler name adorns the walls of many storied institutions – Harvard; the Metropolitan Museum of Art; Oxford; the Louvre. They are one of the richest families in the world, known for their lavish donations in the arts and the sciences. The source of the family fortune was vague, however, until it emerged that the Sacklers were responsible for making and marketing Oxycontin, a blockbuster painkiller that was a catalyst for the opioid crisis-an international epidemic of drug addiction which has killed nearly half a million people.

In this masterpiece of narrative reporting and writing, Patrick Radden Keefe exhaustively documents the jaw-dropping and ferociously compelling reality. Empire of Pain is the story of a dynasty: a parable of 21st century greed.

Now in its third edition, Pharmacology in Clinical Practice has been updated to ensure it remains up-to-date and relevant.

Particular care has been taken to simplify and clarify difficult concepts by explaining the links between pharmacology and physiology by providing definitions of new concepts, and using plain language for ease of understanding. Fundamental concepts, such as pharmacodynamics and pharmacokinetics, are well covered in a matter that is accessible and clear. Individual chapters cover the various systems of the body.

Updates include:

• A colour plate to illustrate the links between pharmacology and physiology
• Additional information on side-effects, contra-indications and patient education for groups of drugs
• A guide on how to access this information, to assist with exam preparation and nursing practice
• An updated chapter on nursing management of drug preparations and treatment
• An updated chapter on clinical applications
• A chapter on the legal framework for dispensing and prescribing.

City Of Broken Dreams brings the global debate about the urban university to bear on the realities of South African rust-belt cities through a detailed case study of the Eastern Cape motor city of East London, a site of significant industrial job losses over the past two decades. The cultural power of the car and its associations with the endless possibilities of modernity lie at the heart of the refusal of many rust-belt motor cities to seek alternative development paths that could move them away from racially inscribed, automotive capitalism and cultures. This is no less true in East London than it is in the motor cities of Flint and Detroit in the US.

Since the end of the Second World War, universities have become increasingly urbanised, resulting in widespread concerns about the autonomy of universities as places of critical thinking and learning. Simultaneously, there is increased debate about the role universities can play in building urban economies, creating jobs and reshaping the politics and identities of cities.

In City Of Broken Dreams, author Leslie Bank embeds the reader's understanding of the university within a history of industrialisation, placing-making and city building.

The role of the Maillard reaction in forming flavors from amino acid and sugar precursors has been studied for many years. To establish the basic chemistry of the reaction, researchers have used model systems, often solutions of a single amino acid with a single sugar. Despite the apparent simplicity of the system, heating such a solution can generate tens if not hundreds of compounds, which requires careful and time-consuming analysis to identify and quantify each component.
Data from the model systems has allowed researchers to study the pathways that lead to flavor formation, and various schemes have been proposed to identify the main "routes" that lead to flavor compounds. Such schemes have led to one of the main control principles, namely an understanding of the role of amino acids in forming some characteristic aromas, e.g., bread flavor from proline, as well as an appreciation of the role of C5 and C6 sugars in controlling the rate of reaction.
Recently, the formation of taste compounds through the Maillard reaction has been investigated and new potent compounds have been discovered that can contribute to the overall flavor formed during the Maillard reaction. These findings also offer the potential for control and manipulation of the Maillard reaction to form specific types of flavor. Although the nature of the end-products of the Maillard reaction in both food and model systems are well documented, applying these principles to control flavor formation in real foods has proved difficult.
This book describes recent research and developments related to the control of the Maillard reaction to give optimum flavor quality. These include kinetic modeling of the reaction, the effect of physical parameters (temperature, time, moisture content, pH), and the effect of chemical parameters (amino acid and sugar composition, the presence of other components). The topics covered relate to real food systems and reaction product flavorings, as well as model systems. Contributors from academia and industry have come together to provide an up to date overview of progress in this important area of flavor research.

Montana's brewing history stretches back more than 150 years to the state's days as a territory. But the art of brewing in Montana has come a long way since the frontier era. Today, nearly forty craft breweries span the Treasure State, and the quality of their output rivals the best craft beer produced anywhere in the country. Maybe it's because there's also a little piece of Montana in every glass, as the state's brewers pride themselves on using cold mountain water and locally sourced barley harvested from Montana's ample fields. From grain to glass, " Montana Beer: A Guide to Breweries in Big Sky Country" tells the story of the brewers and breweries that make the Treasure State's brew so special.

Parameters of fabric texture and their design gives, in a concise and systematic format, a fundamental understanding of fabric structural parameters, their effect on fabric properties and methods of their calculation and design. The book gives an insight into the most popular weaves applied in contemporary weaving practice, the methods of their formation and the kind of fabrics for which they are applied. The book describes conception and methods for fabric design developed by distinguished English, German, Italian, Bulgarian and Russian scientists in accordance with different initial parameters of fabrics. This book has been written for textile designers, technologists, managers, students and researchers.

This ACS Symposium Series book evolved from the ACS symposium "Food Additives and Packaging" sponsored by the Division of Agricultural and Food Chemistry (AGFD) at the 245th ACS National Meeting & Exposition in New Orleans, LA, April 7-11, 2013. The book helps readers understand the rules and regulations governing the use of food additives and food packaging materials in the U.S. and globally. Furthermore, the book investigates novel materials and applications related to food additives and food packaging materials and explores concerns, issues, and current events in the field. The book particularly highlights global regulations, research, development, applications, and evaluation of food additives and food packaging materials. These areas are dynamic, constantly changing, and expected to attract the interest of a broad and diverse readership. Part I of this book highlights how food additives and packaging materials are classified and regulated in different parts of the world and addresses some of the scientific, legal, and practical issues related to these regulations from the perspective representatives. It contains monographs on general aspects of regulatory processes in various countries (U.S., EU, Thailand and Japan) and specific aspects, such as GRAS substances, color additives, enzymes, flavorings, safety assessments, and the National Environmental Policy Act (NEPA). Part II presents some current topics related to the research, development, applications, and evaluation of food additives and food packaging materials, with monographs on applying regulatory knowledge for packaging compliance and evaluating food packaging for pre-packaged irradiated food, and on various emerging technologies, such as a control release packaging system and high pressure processing that can improve the appearance, texture, taste, or shelf-life of food; it also includes monographs that discuss other aspects, such as bisphenol A, PET packaging materials, nanomaterials, and biomaterials.

The foodservice industry is a fundamental part of the hospitality and tourism industries, and contributes to essential guest experiences and the meeting of guests' expectations of service excellence. It encompasses all operations involved in preparing and serving food and beverages to customers away from their homes. Understanding the fundamental components of foodservice management will enhance capabilities and ensure business success. Foodservice management: an African perspective offers an in-depth analysis of the integrated complexities of various types of food and beverage service organisation. Foodservice management: an African perspective provides an overview of the foodservice industry before addressing the organising and control functions, then progresses to the more strategic aspects. Foodservice management: an African perspective is aimed at students studying towards a qualification in the fields of hospitality, culinary, food and beverage or consumer sciences at either higher certificate, diploma or bachelor's level. This textbook is also suitable for courses in foodservice management at TVET colleges. Susina Jooste has over 20 years of experience in higher education and programme development for culinary and hospitality specialisation. She has previously been the owner and director of a private higher education institution which offered qualifications in hospitality and events management, and in hospitality education. She currently serves as research and development specialist at the NID Training NPC and is a director of the South African Culinary and Hospitality Educators Forum.

This symposium series book describes women in mid- to upper- level positions within the chemical industry who have been deemed successful, but are relatively unknown on a national level. Success comes in many forms, and it also comes in many positions. The book will highlight women whose careers range from very technical and obvious to those that are not. Some of the key careers include technical directors, eminent scientists, business managers, patent attorneys, bench chemists, entrepreneurs, human resource directors, and journalists.
The goal of this book is to create a resource where women can find a role model, someone with whom they can relate. Profiling women with a wide diversity of experiences and career opportunities allows the reader to find a common connection. Finally the workplace is not perfect; this series book will highlight both the pleasant and unpleasant career experiences which these women underwent.

Now with a new afterword covering the months-long landmark trials of Elizabeth Holmes and Sunny Balwani. ‘I couldn’t put down this thriller . . . the perfect book to read by the fire this winter.’ Bill Gates Winner of the Financial Times/McKinsey Business Book of the Year Award 2018 The riveting true story of the breathtaking rise and shocking collapse of Theranos, the multibillion-dollar biotech startup founded by Elizabeth Holmes, by the prize-winning journalist who first broke the story and pursued it to the end, despite pressure from its charismatic CEO and threats by her lawyers. In 2014, Theranos founder and CEO Elizabeth Holmes was widely seen as the female Steve Jobs: a brilliant Stanford dropout whose startup ‘unicorn’ promised to revolutionize the medical industry with a machine that would make blood testing significantly faster and easier. Backed by investors such as Larry Ellison and Tim Draper, Theranos sold shares in a fundraising round that valued the company at more than $9 billion, putting Holmes’s worth at an estimated $4.7 billion. There was just one problem: the technology didn’t work. In Bad Blood, John Carreyrou tells the riveting story of the biggest corporate fraud since Enron, a tale of ambition and hubris set amid the bold promises of Silicon Valley. ‘Chilling . . . Reads like a West Coast version of All the President’s Men.’ New York Times Book Review

IN "THE ANTIDOTE," Barry Werth draws upon unprecedented inside reporting spanning more than two decades to provide a groundbreaking closeup of the upstart pharmaceutical company Vertex and the ferocious but indispensable world of Big Pharma that it inhabits.
In 1989, the charismatic Joshua Boger left Merck, then America's most admired business, to found a drug company that would challenge industry giants and transform health care. Werth described the company's tumultuous early days during the AIDS crisis in "The Billion-Dollar Molecule," a celebrated classic of science and business journalism. Now he returns to tell a riveting story of Vertex's bold endurance and eventual success.
The $325 billion-a-year pharmaceutical business is America's toughest and one of its most profitable. It's riskier and more rigorous at just about every stage than any other business, from the towering biological uncertainties inherent in its mission to treat disease; to the 30-to-1 failure rate in bringing out a successful medicine even after a molecule clears all the hurdles to get to human testing; to the multibillion-dollar cost of ramping up a successful product; to operating in the world's most regulated industry, matched only by nuclear power.
Werth captures the full scope of Vertex's twentyfive- year drive to deliver breakthrough medicines. At a time when America struggles to maintain its innovative edge, "The Antidote" is a powerful inside look at one of the most intriguing and important business stories of recent decades.

Our brand new and up to date whisky map shows over 150 distilleries on our exceptionally clear road mapping, allowing you to navigate to your chosen destination. Enlarged inset map of Speyside & clearly defined production regions allows you to plan your distilleries tour according to your taste buds! Distilleries are indexed with addresses and full contact details and clearly defined as those with and without visitor facilities. The best thing to go with your dram apart from a splash of water. Foreword by Blair Bowman, whisky consultant Over 150 whisky distilleries shown with & without visitor facilities Clearly defined whisky producing regions Exceptionally clear road mapping with mileage markers Index to distilleries with full address & contact details Fun facts & information on the reverse Index to place names

This timely book discusses the application of the EU competition rules to pharmaceuticals, covering the prohibitions on anticompetitive agreements and abuse of dominance, and merger control. The author team comprises academic experts and private practitioners who analyse recent case law at both EU (and UK) and Member State levels - in the context of current issues and future trends, including those related to COVID-19 - and examine the impact of competition law on the behaviour of the pharmaceutical industry. The book carefully considers the balance between competition and innovation, as well as between competition and regulation. It concludes that competition and regulation are not alternatives, but complementary, and that novel ways of taking into account risk and real innovation through competition assessments have been developed. Integrating an overview of competition law, IP law and pharmaceutical regulation, this book will be an ideal read for scholars and graduate students, as well as private and public practitioners interested in pharmaceutical and European law.

"Warning. Smoking Kills!" It also corrupts law enforcement officials and eviscerates state institutions. It devours politicians, professionals, business people and ordinary workers in the chase for big bucks and the battle for a slice of an ever-shrinking cigarette market.

Join one of South Africa's former tax sleuths, Johann van Loggerenberg, in a wild ride through the double-dealing world of tobacco's colourful characters and ruthless corporates. Meet the femme fatales, mavericks, mercenaries and grandmasters, and learn how the crime-busting unit led by van Loggerenberg at SARS and its "Project Honey Badger" became a victim of war between industry players and a high-stakes political game driven by state capture.

This is the tale of a few good men and women who dared to try to hold to account a billion-dollar international industry rife with private spy networks, tax evasion, collusion and corruption - ultimately at great cost to themselves and South Africa.

This book examines patent law and policy in biotechnology across the full lifecycle of the patent, focusing on the patent bargain and the public interest. It considers the central issues of how to strike an effective balance of rights, and whether public interest is adequately safeguarded - two issues that are particularly important in areas of rapidly emerging technology. Expert contributors are brought together to explore patent eligibility in biotechnology, focusing on the fields of precision medicine, biofabrication and non-invasive prenatal testing. Chapters also explore the construction and coherence of exceptions to patentability,an examination of FRAND licensing in the context of the internet of medical things, and the possibility of using licensing to encourage or ensure the ethical use of patented technologies. With its carefully constructed analysis, this book will be an excellent resource for academic researchers, and students, in the fields of biotechnology law, pharmaceutical law and intellectual property law. It will also be useful for legal practitioners and policymakers, as well as charitable bodies and non-governmental organisations.

Environmental Fate and Safety Management of Agrochemicals discusses residue analysis, environmental fate and safety management, environmental risk assessment, metabolism, resistance and management, and advances in formulation and application technology from the academic, government, and industry perspective.
Meaningful ecological and environmental risk assessment of pest control agents is possible only when accurate and credible metabolic and environmental fate data is available. The advent of affordable and sensitive liquid chromatography/mass spectrometry (LC/MS) has greatly increased our ability to detect environmentally relevant metabolites and degradation products following the application of these materials. Furthermore, ecological risk assessment and monitoring of pesticide resistance in field populations has become more feasible and cost effective by employing hig-hroughout molecular diagnostic techniques on the genetic leve3l and LC/MS techniques on the proteomic and meabolomic levels.
Efficient formulations and application technologies have greatly reduced the amount of materials that are required to achieve effective pest control and hence reduce their ecological and environmental impacts. Controlled release, stabilization and dispersion technologies have provided the pest manager with new tools that allow them to use necessary pest control options in "best management strategies."