Infertility affects an estimated 50 million women worldwide and has a wide range of causes including eating disorders, smoking, chemotherapy, diseases such as STIs, as well as genetic factors and malformations. The preliminary assessment and diagnosis involves a potentially broad array of lab and imaging tests, physical examination and potentially genetic tests, after which a management plan is selected depending on the woman’s age, the cause(s) and duration of the infertility. Female Infertility: Core Principles and Clinical Management provides clinicians with a comprehensive understanding of how best to overcome infertility using the various treatment options now available. The book opens with an introduction to the anatomy and physiology of the female reproductive system before describing the assessment and investigative tools used in primary and secondary healthcare settings. Subsequent chapters describe how to secure optimum functionality of the ovaries, the measurement of ovarian reserves, stimulation protocols and the process of oogenesis and oocyte collection. Given their potential adverse impact on the quality of oocytes and implantation, dedicated chapters focus on the treatment of polycystic ovarian syndrome and endometriosis. Concluding chapters address fast moving and future technologies, including the use of pluripotent stem cells for treating different medical conditions; the management of mitochondrial disease and the transplantation of cryopreserved ovaries. Highly illustrated and written by a team of international experts in the field, Female Infertility: Core Principles and Clinical Management serves as an essential resource for all clinicians, nurses and clinical scientists who specialise in reproductive medicine, gynecology, oncology, infertility and embryology.

The trusted resource that asks the right questions so that you'll be equipped with the answers! Part of the successful PreTest series, the new edition of PreTest Obstetrics & Gynecology has been heavily revised to reflect all the critical new information needed to succeed on your rotation and on the shelf exam. It features hundreds of high yield questions, along with clear, targeted answers explaining both correct and incorrect answer choices. To ensure that all content is relevant, timely, and high-yield, this edition was reviewed by students who successfully completed their clerkships and passed the shelf exam.

This book is a comprehensive guide to addressing, working with, and healing from emotional struggles related to fertility and eating disorders. Covering the emotional, psychological and physical impact of anorexia nervosa, bulimia and binge eating disorder, this book explores the lived experience of numerous women and men who have lived with eating disorders, fertility, and parenthood. It delves into research on medical complications that can affect fertility, attachment, the experience of shame, adjustment to the postpartum period, and offers clinical tools for therapists to use to support clients from a weight and body neutral perspective. Those who read this book will come away with a renewed sense of hope for recovery and healing from serious mental illnesses, and the notion that the value of having a family may be stronger than the eating disorder itself. The only book of its kind, The Clinical Guide to Fertility, Motherhood and Eating Disorders will be useful to practitioners, therapists, and scholars alike.

Rare gynecological cancers kill all too commonly Gynecological cancer is a frightening prospect for women. It is terrifying also for physicians who need, but often can t find, guidance on how to investigate and appropriately treat the tumors. Rare cancers provide greater challenges as information can be harder to find and more difficult to verify. Rare Gynecologic Cancers: Diagnosis and Management brings together all you need to know on these life-threatening diseases. Straightforward summaries of pathophysiologic processes lead to the investigations that will improve your diagnostic accuracy. This provides the basis for you to identify effective treatment strategies for your patients. Written by a world-leading team of Editors and Authors and covering cancers of the Ovaries Uterus Vulva Vagina Cervix Rare Gynecologic Cancers: Diagnosis and Management will guide you to the best life-saving treatment for your patients.

The landmark text that has served generations of obstetrician-gynecologists-fully updated with the most current perspectives of the field Williams Obstetrics has defined the discipline for generations of obstetrician-gynecologists. Written by authors from the nationally renowned University of Texas Southwestern Medical Center and Parkland Hospital, the new edition of this authoritative, evidence-based work maintains its trademark comprehensive coverage and applicability at the bedside, while offering the most current information and insights. The culmination of a century of clinical thought, Williams Obstetrics, 26th Edition delivers expert coverage of obstetrical complications, such as preterm labor, pregnancy-related hypertension, infection, and hemorrhage. It additionally offers foundational content on reproductive anatomy, physiology, and prenatal care. The authors have enhanced this edition with 1,000+ full-color illustrations, plus an increased emphasis on the fast-growing subspecialty of Maternal-Fetal Medicine. No other text matches the long-established scientific rigor and accessibility of Williams Obstetrics. With its state-of-the-art design and review of the newest advances and protocols, this not-be-missed clinical companion brings positive outcomes within reach. New and updated content includes: Increased focus on Maternal-Fetal Medicine Greater coverage of hypertension and hemorrhage Deeper insights into in-utero complications Expanded fetal t section includes cutting-edge fetal imaging, genetics, prenatal diagnosis, and fetal disorders and therapy Basic science, physiology of labor, preterm labor updated with contemporaneous publications in the literature More obstetrical sonography figures Eye-catching illustrations, including updated graphs, sonograms, MRIs, photographs, and photomicrographs

It is no surprise that women and men experience biological and physiological differences fundamentally and throughout the lifecycle. What is surprising is that faced with such a self-evident truth, there should be so little consideration to date of how these differences affect susceptibility to disease and metabolic response to dietary treatment. Understanding these differences and developing a gender-based approach focusing on the specific needs and conditions of women is crucial to achieve effective nutritional strategies for women's health. Expanding the knowledge-base regarding sex, nutrition, and medicine, Optimizing Women's Health through Nutrition presents the biology, physiology, and metabology unique to women. The book demonstrates in a practical, accessible manner the scientific application of this data addressing lifecycle changes, disease prevention, and treatment. Based on sound research and supported by extensive references, it begins by describing recent research on biological and physiological differences and how these differences translate into varying disease trends between the sexes. Contributions describe the nutritional needs of women during the lifecycle, particularly during adolescence, pregnancy and lactation, premenopause, and menopause and midlife stages. The bulk of the book addresses each of the common major diseases or conditions that specifically affect the health of women. It emphasizes the role of nutrition in disease risk reduction as well as management and treatment of disease. Specific disease selection was dictated by those in which women are more vulnerable or have a higher incidence than men. The concluding section identifies areas for future research and strategic areas of investigation for researchers and health professionals, government regulators, and food industry professionals involved in creating novel foods that enhance women's health.

This book is a guide to labour and delivery management for trainees in obstetrics and gynaecology, and midwives. Divided into three sections, the text begins with detailed discussion on labour, from preparation before labour and delivery, through the different stages of labour, to postpartum care. The next section covers caesarean delivery, and the third, 'special labour' which explains labour complications, twins, prelabour rupture of membranes, and more. The book is authored by recognised experts from the USA and Italy, and is based on evidence from randomised controlled trials (RCTs). Clinical photographs, diagrams and tables further enhance learning. Key points Guide to labour and delivery management for trainees in obstetrics and gynaecology, and midwives Text based on evidence from randomised controlled trials (RCTs) Recognised author team from USA and Italy Includes clinical photographs, diagrams and tables

This book provides those studying for the MRCOG Part 2 examination with welcome practice in answering Extended Matching Questions (EMQs). Updated throughout to map onto the MRCOG syllabus from September 2016, the book is designed to test the candidate's theoretical and practical knowledge of obstetrics and gynaecology. An introductory section on exam techniques is followed by a collection of 41 EMQ themes, split into obsterics and gynaecology. The questions are based on common clinical scenarios and cover a variety of topics. Answers are included after each topic, and these include explanatory material and useful references.

Endometriosis causes a variety of symptoms from painful periods and backache to fertility problems. If you have painful periods and wonder if you might have endometriosis, or if you've already been diagnosed, you need the best possible information, help and support. This book aims to help you understand your symptoms, talk to your doctor without embarrassment, and it explains the tests and the treatment options. There's also sympathetic advice to help you cope with pain, deal with your own feelings about having endometriosis, and talk to your partner about how you feel. "Women with endometriosis need simple, clear information to enable them to decide for themselves which kind of treatment may be right for them. This book is written in a clear question and answer format and covers everything from explanations of symptoms to treatments and self-help. A book aimed directly at women, in a language they can understand." - National Endometriosis Society

This book systematically reviews and discusses recent studies and articles on the immunology of female genital tract tissue. The scope is broad, encompassing innate immune responses, adaptive (humoral and cell-mediated) immunity, the immunology of menstruation, the immunology of viral and bacterial infections, the immunology of normal and abnormal pregnancy, and immunological infertility. Throughout, tables and illustrations are judiciously used to facilitate understanding. Immunology of the Female Genital Tract will serve as an invaluable source of up-to-date information for all with an interest in this subject.

Improvements in the detection of fetal and neonatal brain injuries, advances in our understanding of the pathophysiology, cellular and molecular bases of encephalopathy, and new treatment options have all combined to produce significant changes in the management of neonatal brain disorders in the past few years. This new edition of Fetal and Neonatal Brain Injury brings the reader fully up to date with all advances in clinical management and outcome assessment. Updated material includes inflammation focusing in particular on chorioamnionitis and fetal brain injury; genetic brain injury; and expanded sections on cholestasis, diabetes, and thyroid disease. An updated, highly illustrated chapter on structural and functional imaging of the fetal and neonatal brain is also included. An outstanding international team of highly experienced neonatologists and maternal-fetal medicine clinicians have produced a practical, authoritative clinical text that gives clear management advice to all clinicians involved in the treatment of these patients.

Breast cancer is the most common cancer in females that accounts for highest cancer specific deaths worldwide. In the last few decades research has proven that breast cancer can be treated if diagnosed at early stages and proper therapeutic strategy is adopted. Omics-based recent approaches have unveiled the molecular mechanism behind the breast tumorigenesis and aid in identification of next-generation molecular markers for early diagnosis, prognosis and even the effective targeted therapy. Significant development has taken place in the field of omics in breast cancer in the last decade. The most promising omics approaches and their outcomes in breast cancer have been presented in this book for the first time. The book covers omics technologies and budding fields such as breast cancer miRNA, lipidomics, epigenomics, proteomics, nutrigenomics, stem cell, pharmacogenomics and personalized medicine and many more along with conventional topics such as breast cancer management etc. It is a research-based reference book useful for clinician-scientists, researchers, geneticists and health care industries involved in various aspects of breast cancer. The book will also be useful for students of biomedicine, pathology and pharmacy.

This volume offers an up-to-date overview on the major areas of gynecological endocrinology, presenting the latest advances in adolescent gynecological endocrinology, assisted reproduction, menstrual-related disorders, sexuality and transsexualism, polycystic ovary syndrome, myometrial pathology and adenomyosis, obesity and metabolic syndrome, hormonal contraception, premature ovarian failure and menopause. In each chapter the recent advances deriving from basic science and clinical investigations are related to the practical management of the condition under consideration, taking into account the need for individualized therapies. The book is published within the ISGE Book Series, a joint venture between the International Society of Gynecological Endocrinology and Springer and is based on the 2014 International School of Gynecological and Reproductive Endocrinology Winter Course. It will be an important tool for obstetricians and gynecologists, endocrinologists and experts in women's health as well as interested GPs.

This book offers a critical review of the pelvic sciences-past, present and future-from an anatomical and physiological perspective and is intended for researchers, medical practitioners and paramedical therapists in the fields of urology, gynecology and obstetrics, proctology, physiotherapy, as well as for patients. The book starts with a "construction plan" of the pelvis and shows its structural consequences. The historical background of pelvic studies proceeds from medieval and early Italian models to the definitive understanding of the pelvic anatomy in the Seventeenth century. During these eras of pelvic research, concepts and approaches developed that are illustrated with examples from comparative anatomy and from mutations, also with regard to the biomechanics of pelvic structures. Perceptions of the pelvis as an important element in sexual arousal and mating conduct are discussed, as well as attitudes to circumcision, castration and other mutilations, in its anthropological, social context. The anatomy and physiology of the pelvic wall and its organs as well as the development of these pelvic organs are covered as a prerequisite to understanding, for example, the spread of pelvic carcinoma and male and female bladder muscle function. Connective pelvic tissue is examined in its reinforcing capacity for pelvic structures, but also as a "hiding place" for infections. Innervations and reflexes relayed through the pelvic nerves are discussed in order to explain incontinence, sphincter function and the control of smooth and striated muscles in the pelvis. Catheters and drugs acting on pelvic function are described, and a critical review of alternative clinical methods for treating pelvic dysfunctions is provided.

During recent decades, more than 100 surgical procedures have been proposed to treat pelvic organ prolapse, and surgeons are still searching for the ideal approach. Although generally accepted guidelines and algorithms are still lacking, careful preoperative work-up and patient selection can serve as a sound basis for tailored surgery. In this comprehensive book, leading experts from around the world provide a detailed, up-to-date overview of the diagnostic and surgical approaches employed in patients with prolapse of the middle or posterior pelvic floor compartment. Each surgical technique is explained step by step with the aid of instructive figures. Guidance is also included on the management of surgical complications and of recurrent disease – aspects that are too frequently overlooked in the scientific literature. This book will prove essential reading for all who are interested in functional colorectal disorders of the pelvic floor and will represent a unique and invaluable source of knowledge for general surgeons, colorectal surgeons, and urogynecologists, whether in training or practice.   ​  

The purpose of the The Active Female: Health Issues Throughout the Lifespan, 2nd Edition is twofold: (1) to increase the awareness of wellness and fitness issues for active females and their family members; and (2) to provide an avenue for medical practitioners, allied health professionals, health educators, and certified individuals in sports medicine to gain critical, updated knowledge of a field specific to active females. Part I of the book offers a foundation to help the reader understand the interrelationship among body image concerns, the female reproductive cycle, and musculoskeletal anatomy/physiology of females that makes their health risks and concerns unique. Reproductive health is discussed by a prominent researcher in reproduction/endocrinology. An overview of the Female Athlete Triad which is a syndrome of three interrelated conditions (isordered eating, menstrual disturbances and bone loss) is presented in Part II. Physicians and certified professionals in sports medicine discuss the individual components of the triad, relating not only to the athletic female but also to the recreationally active woman throughout the lifespan. In Part III, Prevention and management of common musculoskeletal injuries is addressed by a female orthopedic surgeon who sub-specializes in treating female athletes. Finally, appropriate exercise and nutritional guidelines for active females are discussed in Parts IV-V of the book by certified professionals and licensed physicians in sports medicine. An invaluable addition to the literature, The Active Female: Health Issues Throughout the Lifespan, 2nd Edition will be of great interest to physicians, allied health care practitioners, medical/other wellness educators, and students who are interested in advancing women's health issues. Sports medicine specialists, family practitioners, gynecologists, team physicians, residents in sports medicine, athletic trainers, health educators, nurses, physicians assistants, physical therapists, sport psychologists, counselors, athletic trainers, and other members of the sports medicine team should also find this title of significant interest.

This is a novel text that highlights the controversial areas in the management of gynecological cancers. None of the topics in this book have definitive answers; they represent the everyday decision-making facing gynecologists, oncologists, radiologists, pathologists and other health professionals treating women with these conditions. This book is not to be used as a traditional textbook; it is a text that specialists and trainees will use to help them weigh up the arguments that exist in a variety of areas in the treatment of gynecological cancers. Each chapter will have two or more authors, selected either for their opposing views or for their ability to provide an opposite view or opinion to the other. The content will be evidence-based, illustrating contrasting evidence and scientific opinion in the literature. Each chapter will close on a summary indicating the direction of research needed to address the issues being discussed.

This book, part of the series Rare Diseases of the Immune System, offers comprehensive, up-to-date coverage of the pathophysiology and management of the antiphospholipid syndrome (APS). Immunologic and genetic aspects are discussed and the pathogenic mechanisms responsible for such phenomena as APS-mediated thrombosis and pregnancy loss/complications are explained. The main clinical manifestations, classification criteria and diagnostic tools are identified, and close attention is paid to the nature of the involvement of various organs or organ systems in APS. Specific chapters describe the treatment of the different symptoms, therapies of value in avoiding recurrences, and innovative treatment approaches. The authors are senior experts in the field who are aided by younger fellows, ensuring that the book is also educationally oriented. This handy volume will be a valuable tool for postgraduates in training and professionals wishing to extend their knowledge of this specific syndrome.

Representing the most relevant procedures and technologies aiding the advance of the field of HPV-mediated carcinogenesis of the cervix and other anatomical regions of squamocolumnar transition, such as the anorectum, penis, and oropharynx, Cervical Cancer: Methods and Protocols compiles a detailed collection of practical chapters. The first half of the book covers HPV types, pathogenesis of cervical cancer (CxCA), prevention, and novel potential drug targets, while the second half explores pathology, genomics, modeling of CxCA, and experimental therapeutic strategies. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and vital, Cervical Cancer: Methods and Protocols serves as a valuable resource to both bench scientists and clinicians who step into the realm of high-risk HPVs and CxCA for the first time or those who wish to learn novel approaches or expand their toolbox for the study of CxCA.

Advances in technology now offer promising solutions to deal with the chronological aging of the cell, tissue or organ to synchronize its existence and its use. This book covers the developments in and benefits of the latest vitrification technology and its extensive applications in reproductive medicine. Protocols of gametes (oocyte and sperm), embryos, blastocysts and ovarian tissue cryopreservation have been reviewed by leaders in the field. In order to address the escalation in cross-border reproductive tourism entailing the transfer of reproductive cells and tissues rather than the patient, the challenges, caution and emerging possibilities of nitrogen vapor shipment of vitrified cells have been discussed. Current perspectives on oocyte banking present the reader with options and solutions to effectively utilize these gametes despite the physiological deterrents.The versatile applications and potential of vitrification of human embryonic stem cells, discussed in the concluding chapter, is an exciting reality offered by vitrification to help overcome numerous stumbling blocks in the management of various disorders.

This volume represents an up-to-date overview on the major areas of gynecological endocrinology, providing the reader with a complete explanation of female endocrine regulation and metabolism and relevant disorders and treatment. It is published within the International Society of Gynecological Endocrinology (ISGE) Series and is based on the 2013 International School of Gynecological and Reproductive Endocrinology Summer Course. The book covers a very wide range of topics – from primary amenorrhea to menopause, from the impact of ovarian surgery on fertility to fertility cryopreservation, from metabolic syndrome and polycystic ovary to premature ovarian failure and from the clinical impact of selective progesterone receptor modulators to the use of progesterone in prevention of premature labor. It will be an important tool for obstetricians and gynecologists, endocrinologists and experts in women’s health as well as interested GPs.

This open access book looks at the dramatic history of ovariotomy, an operation to remove ovarian tumours first practiced in the early nineteenth century. Bold and daring, surgeons who performed it claimed to be initiating a new era of surgery by opening the abdomen. Ovariotomy soon occupied a complex position within medicine and society, as an operation which symbolised surgical progress, while also remaining at the boundaries of ethical acceptability. This book traces the operation's innovation, from its roots in eighteenth-century pathology, through the denouncement of those who performed it as 'belly-rippers', to its rapid uptake in the 1880s, when ovariotomists were accused of over-operating. Throughout the century, the operation was never a hair's breadth from controversy.

The first complete reference dedicated to the full spectrum of women's imaging topics "Women s imaging" refers to the use of imaging modalities (X-ray, ultrasound, CT scan, and MRI) available for aiding in the diagnosis and care of such female-centric diseases as cancer of the breast, uterus, and ovaries. Currently, there is no single reference source that provides adequate discussions of MRI and its important role in the diagnosis of patients with women's health issues. Thoroughly illustrated with the highest-quality radiographic images available, Women s Imaging: MRI with Multimodality Correlation provides a concise overview of the topic and emphasizes practical image interpretation. It makes clear use of tables and diagrams, and offers careful examination of differential diagnosis with special notes on key learning points. Placing great emphasis on magnetic resonance imaging (MRI), while providing correlations to other important imaging modalities, the comprehensive book features the latest guidelines on imaging screening and includes in-depth chapter coverage of: * Pelvis MRI: Introduction and Technique * Imaging the Vagina and Urethra * Pelvic Floor Imaging * Imaging the Uterus * Imaging the Adnexa * Imaging Maternal Conditions in Pregnancy * Fetal Imaging * Breast MRI: Introduction and Technique * ACR Breast MRI Lexicon and Interpretation * Preoperative Breast Cancer Evaluation and Advanced Breast Cancer Imaging * Postsurgical Breast and Implant Imaging * MR-Guided Breast Interventions Providing up-to-date information on many of the health issues that affect women across the globe, Women's Imaging will appeal to all general radiologists especially those specializing in body imaging, breast imaging, and women s imaging as well as gynaecologists and obstetricians, breast surgeons, oncologists, radiation oncologists, and MRI technologists.

The Lamaze method is virtually synonymous with natural childbirth in America. In the 1970s, taking Lamaze classes was a common rite of passage to parenthood. The conscious relaxation and patterned breathing techniques touted as a natural and empowering path to the alleviation of pain in childbirth resonated with the feminist and countercultural values of the era. In Lamaze, historian Paula A. Michaels tells the surprising story of the Lamaze method from its origins in the Soviet Union in the 1940s, to its popularization in France in the 1950s, and then to its heyday in the 1960s and 1970s in the US. Michaels shows how, for different reasons, in disparate national contexts, this technique for managing the pain of childbirth without resort to drugs found a following. The Soviet government embraced this method as a panacea to childbirth pain in the face of the material shortages that followed World War II. Heated and sometimes ideologically inflected debates surrounded the Lamaze method as it moved from East to West amid the Cold War. Physicians in France sympathetic to the communist cause helped to export it across the Iron Curtain, but politics alone fails to explain why French women embraced this approach. Arriving on American shores around 1960, the Lamaze method took on new meanings. Initially it offered a path to a safer and more satisfying birth experience, but overtly political considerations came to the fore once again as feminists appropriated it as a way to resist the patriarchal authority of male obstetricians. Drawing on a wealth of archival evidence, Michaels pieces together this complex and fascinating story at the crossroads of the history of politics, medicine, and women. The story of Lamaze illuminates the many contentious issues that swirl around birthing practices in America and Europe. Brimming with insight, Michaels' engaging history offers an instructive intervention in the debate about how to achieve humane, empowering, and safe maternity care for all women.