It is no surprise that women and men experience biological and physiological differences fundamentally and throughout the lifecycle. What is surprising is that faced with such a self-evident truth, there should be so little consideration to date of how these differences affect susceptibility to disease and metabolic response to dietary treatment. Understanding these differences and developing a gender-based approach focusing on the specific needs and conditions of women is crucial to achieve effective nutritional strategies for women's health. Expanding the knowledge-base regarding sex, nutrition, and medicine, Optimizing Women's Health through Nutrition presents the biology, physiology, and metabology unique to women. The book demonstrates in a practical, accessible manner the scientific application of this data addressing lifecycle changes, disease prevention, and treatment. Based on sound research and supported by extensive references, it begins by describing recent research on biological and physiological differences and how these differences translate into varying disease trends between the sexes. Contributions describe the nutritional needs of women during the lifecycle, particularly during adolescence, pregnancy and lactation, premenopause, and menopause and midlife stages. The bulk of the book addresses each of the common major diseases or conditions that specifically affect the health of women. It emphasizes the role of nutrition in disease risk reduction as well as management and treatment of disease. Specific disease selection was dictated by those in which women are more vulnerable or have a higher incidence than men. The concluding section identifies areas for future research and strategic areas of investigation for researchers and health professionals, government regulators, and food industry professionals involved in creating novel foods that enhance women's health.

Originally published in 1982 Obstetrics and Gynaecology in Tudor and Stuart England traces the development of obstetrics and gynaecology over the past two centuries. Between the 16th and 18th century midwifery passed from a female mystery, employing traditional medicines and superstitions, to a scientifically-based clinical skill, with both gains and losses to the patient. The case-mortality was high enough to make the increasing involvement of male surgeons socially acceptable, despite sexual taboos. Thus, as scientific knowledge of anatomy and physiology developed and was applied in the form of new techniques, so the midwives, who had less opportunity and inclination to acquire the new knowledge and skills, lost esteem and by the mid-eighteenth century were increasingly relegated to the service of the poor. The book also examines ideas about sexuality, menstruation, conception, pregnancy and lactation and shows how the views of society about femaleness, marital relations and the management of pregnancy and childbearing were influenced by these notions.

In celebration of its 20th anniversary, a thoroughly revised and expanded edition of the leading book on fertility and women's reproductive health. Since the publication of Taking Charge of your Fertility two decades ago, Toni Weschler has taught a whole new generation of women how to become pregnant, avoid pregnancy naturally and gain better control of their gynecological and sexual health by taking just a couple minutes a day using the proven Fertility Awareness Method. Now, this 20th Anniversary Edition has been thoroughly revised and fully updated with: the latest medical advances in assisted reproductive technologies (ART) more in-depth coverage of women's gynecological and sexual health new illustrations, photographs, and an expanded color insert new sample charts an expanded appendix Six new chapters including: Three Prevalent Conditions--Endometriosis, Ovarian Cysts and PCOS Natural Ways to Balance Your Hormones Preserving Your Future Fertility Miscarriages Idiopathic Infertility Causes of Unusual Bleeding Clear and comprehensive, yet warm and approachable, Taking Charge of Your Fertility is one of the most universally lauded health books on the market today. It is an essential reference for every woman of reproductive age.

Ovarian stimulation is the starting point of reproductive medicine but the procedure can result in adverse reactions particularly the dangerous ovarian hyperstimulation syndrome. Fully revised in line with modern practice of ovarian stimulation, this new edition is divided into six sections that cover mild forms, non-conventional forms, IVF, complications and their management, alternatives, and the practicalities of procedures. All aspects of ovarian stimulation are discussed including the different stimulation protocols from which to choose, the management of poor responders and hyper-responders, as well as stimulation in patients with PCOS. Comprehensively reviewing the modern approach to ovarian stimulation, the alternative procedures are also described, both in IVF and other methods of assisted reproduction. Written by leading experts on reproductive health and fertility, this book will assist infertility specialists, gynecologists, reproductive endocrinologists and radiologists in determining successful treatment for their patients.

Offers an expert blend of sound theory and evidence based therapy for residents and practitioners. Provides a clear path through the increasing complexity of ART options and techniques, using clinical experience and common practical sense. Condenses the aspects of knowledge and practice most relevant for learning the practical basics of diagnosis and decision making.

Improvements in the detection of fetal and neonatal brain injuries, advances in our understanding of the pathophysiology, cellular and molecular bases of encephalopathy, and new treatment options have all combined to produce significant changes in the management of neonatal brain disorders in the past few years. This new edition of Fetal and Neonatal Brain Injury brings the reader fully up to date with all advances in clinical management and outcome assessment. Updated material includes inflammation focusing in particular on chorioamnionitis and fetal brain injury; genetic brain injury; and expanded sections on cholestasis, diabetes, and thyroid disease. An updated, highly illustrated chapter on structural and functional imaging of the fetal and neonatal brain is also included. An outstanding international team of highly experienced neonatologists and maternal-fetal medicine clinicians have produced a practical, authoritative clinical text that gives clear management advice to all clinicians involved in the treatment of these patients.

Endometriosis causes a variety of symptoms from painful periods and backache to fertility problems. If you have painful periods and wonder if you might have endometriosis, or if you've already been diagnosed, you need the best possible information, help and support. This book aims to help you understand your symptoms, talk to your doctor without embarrassment, and it explains the tests and the treatment options. There's also sympathetic advice to help you cope with pain, deal with your own feelings about having endometriosis, and talk to your partner about how you feel. "Women with endometriosis need simple, clear information to enable them to decide for themselves which kind of treatment may be right for them. This book is written in a clear question and answer format and covers everything from explanations of symptoms to treatments and self-help. A book aimed directly at women, in a language they can understand." - National Endometriosis Society

This open access book looks at the dramatic history of ovariotomy, an operation to remove ovarian tumours first practiced in the early nineteenth century. Bold and daring, surgeons who performed it claimed to be initiating a new era of surgery by opening the abdomen. Ovariotomy soon occupied a complex position within medicine and society, as an operation which symbolised surgical progress, while also remaining at the boundaries of ethical acceptability. This book traces the operation's innovation, from its roots in eighteenth-century pathology, through the denouncement of those who performed it as 'belly-rippers', to its rapid uptake in the 1880s, when ovariotomists were accused of over-operating. Throughout the century, the operation was never a hair's breadth from controversy.

Infertility affects about five million individuals of childbearing age in the United States, yet infertility is a subject about which many people are reluctant to talk. This book discusses extensively many options available to individuals struggling with infertility. Infertility can result from a number of causes and affects men and women in equal numbers. Difficulty conceiving can take a heavy toll on couples both physically and psychologically and can lead to depression and marital discord. There are, however, many options available to those struggling with infertility for having a child. These include innovative medical procedures and powerful drugs as well as a variety of alternative treatment approaches, surrogacy, and adoption. A part of Greenwood's Health and Medical Issues Today series, this book provides an overview of these options and examines the many health, financial, and ethical decisions of each that must be considered when choosing one. Part I explores what causes infertility and the history and evolution of its treatment and then examines the options available today, detailing how they work, their success rates, and their risks. Additionally, it addresses controversial topics such as the legislation of assisted reproductive technologies and the regulation of fertility clinics. Part II delves into the many scientific, economic, and ethical debates that surround infertility treatment, presenting a clear and objective analysis of the issues. Part III provides a variety of useful supplementary materials, including case studies, a timeline of critical events, a glossary, and a directory of resources.

For over thirty years, the Oxford Handbook of Clinical Specialties has guided students and junior doctors through their clinical placements, renowned for providing all the information needed for both practice and revision in a deceptively small package. Now in its eleventh edition, the Handbook has been revitalized by an expanded team of specialty experts and junior doctors to guide readers through each of the specialties encountered through medical school and Foundation Programme rotations, while remaining true to the humanity and patient focus of the original edition. Updated with the latest advice and clinical guidelines, packed full of high-quality illustrations, boxes, tables, and classifications, and with a brand new chapter on how to survive your junior doctor years and beyond, this handbook is ideal for both study and use at direct point of care. Each chapter is clear and concise and filled with medical gems, with features including ribbons to mark your most-used pages and mnemonics to help you memorize and retain key facts. With reassuring and friendly advice throughout, this is the ultimate guide and revision tool for every medical student and junior doctor for each clinical specialty placement. This well-loved Handbook remains the perfect companion to the Oxford Handbook of Clinical Medicine, together encompassing the entire spectrum of clinical medicine and unmatched by any competitor in their class, helping you become the doctor you want to be.

Written and edited by leading, internationally recognized clinicians and scientists in reproductive medicine and related fields, this unique text is a practical and comprehensive review of the clinical and scientific significance of unexplained male and female infertility and its management. The book is divided into thematic sections to ensure the most useful presentation of topics, opening with definitions and epidemiology of unexplained infertility, including discussion of the WHO's cutoff values for human semen characteristics and its ramifications. Sections covering male and female reproductive pathophysiology follow respectively, covering biological, genetic and environmental causative factors, with a subsequent section on evaluative techniques for male and female patients. Expectant, medical and surgical treatment strategies comprise the fifth section of the book, where active interventions and outcomes of each treatment modality are carefully considered. The final section discusses assisted reproductive techniques to manage unexplained infertility, such as intrauterine insemination and in vitro fertilization, as well as future perspectives. Thoughtful and enlightening, Unexplained Infertility: Pathophysiology, Evaluation and Treatment will be an invaluable resource for all clinicians and scientists working in the fields of reproductive medicine and infertility.

This volume reviews the evolution of information regarding the epidemiology of DCIS and its modes of detection, as well as treatment options as a function of both clinical trial data and ongoing investigational therapeutic prospects. Several of the challenging and clinically-relevant scenarios of DCIS that appear in daily practice is discussed, including the difficulties of distinguishing "true" DCIS from borderline patterns of other breast diseases and the therapeutic implications of differentiating these various diagnoses. Particular attention is paid to pathologic evaluation of DCIS, including histologic patterns and the importance of margin evaluation/margin control. The text also explores the data regarding DCIS in medical research in hereditary susceptibility for breast cancer and race/ethnicity-associated disparities in breast cancer. Written by experts in the field, Ductal Carcinoma In Situ and Microinvasive/Borderline Breast Cancer is a comprehensive, state-of-the art review of the field, and serves as a valuable resource for clinicians, surgeons and researchers with an interest in breast cancer.

This book systematically reviews and discusses recent studies and articles on the immunology of female genital tract tissue. The scope is broad, encompassing innate immune responses, adaptive (humoral and cell-mediated) immunity, the immunology of menstruation, the immunology of viral and bacterial infections, the immunology of normal and abnormal pregnancy, and immunological infertility. Throughout, tables and illustrations are judiciously used to facilitate understanding. Immunology of the Female Genital Tract will serve as an invaluable source of up-to-date information for all with an interest in this subject.

The Lamaze method is virtually synonymous with natural childbirth in America. In the 1970s, taking Lamaze classes was a common rite of passage to parenthood. The conscious relaxation and patterned breathing techniques touted as a natural and empowering path to the alleviation of pain in childbirth resonated with the feminist and countercultural values of the era. In Lamaze, historian Paula A. Michaels tells the surprising story of the Lamaze method from its origins in the Soviet Union in the 1940s, to its popularization in France in the 1950s, and then to its heyday in the 1960s and 1970s in the US. Michaels shows how, for different reasons, in disparate national contexts, this technique for managing the pain of childbirth without resort to drugs found a following. The Soviet government embraced this method as a panacea to childbirth pain in the face of the material shortages that followed World War II. Heated and sometimes ideologically inflected debates surrounded the Lamaze method as it moved from East to West amid the Cold War. Physicians in France sympathetic to the communist cause helped to export it across the Iron Curtain, but politics alone fails to explain why French women embraced this approach. Arriving on American shores around 1960, the Lamaze method took on new meanings. Initially it offered a path to a safer and more satisfying birth experience, but overtly political considerations came to the fore once again as feminists appropriated it as a way to resist the patriarchal authority of male obstetricians. Drawing on a wealth of archival evidence, Michaels pieces together this complex and fascinating story at the crossroads of the history of politics, medicine, and women. The story of Lamaze illuminates the many contentious issues that swirl around birthing practices in America and Europe. Brimming with insight, Michaels' engaging history offers an instructive intervention in the debate about how to achieve humane, empowering, and safe maternity care for all women.

Breast cancer is the most common cancer in females that accounts for highest cancer specific deaths worldwide. In the last few decades research has proven that breast cancer can be treated if diagnosed at early stages and proper therapeutic strategy is adopted. Omics-based recent approaches have unveiled the molecular mechanism behind the breast tumorigenesis and aid in identification of next-generation molecular markers for early diagnosis, prognosis and even the effective targeted therapy. Significant development has taken place in the field of omics in breast cancer in the last decade. The most promising omics approaches and their outcomes in breast cancer have been presented in this book for the first time. The book covers omics technologies and budding fields such as breast cancer miRNA, lipidomics, epigenomics, proteomics, nutrigenomics, stem cell, pharmacogenomics and personalized medicine and many more along with conventional topics such as breast cancer management etc. It is a research-based reference book useful for clinician-scientists, researchers, geneticists and health care industries involved in various aspects of breast cancer. The book will also be useful for students of biomedicine, pathology and pharmacy.

Endometriosis is one of the most common gynecological diseases, causing pelvic pain, infertility, and cancer. The condition reduces the quality of life for the estimated 10% of menstruating women who are affected by it. This book provides a clear insight into the pathogenesis and pathophysiology of endometriosis—essential information for clinicians intending to successfully treat the condition. The first part covers a range of topics including stem cells, NK cells, macrophages, inflammation, cytokines, epigenetics, prostaglandin, sex steroids, aromatase, apoptosis, nerve fibers, and malignant transformation to aid in understanding the pathogenesis and pathophysiology of the disease. The second part provides useful tools for therapy, specifically, notable recent techniques in prevention, imaging, biomarkers, medical treatments, surgical treatments, prevention of recurrence, and infertility treatments. Each chapter was written by an expert in the field, with nearly 40 researchers and clinicians contributing to the work. This book will be highly useful to clinicians as well as to research scientists who are interested in this enigmatic disease.  

This volume offers an up-to-date overview on the major areas of gynecological endocrinology, presenting the latest advances in adolescent gynecological endocrinology, assisted reproduction, menstrual-related disorders, sexuality and transsexualism, polycystic ovary syndrome, myometrial pathology and adenomyosis, obesity and metabolic syndrome, hormonal contraception, premature ovarian failure and menopause. In each chapter the recent advances deriving from basic science and clinical investigations are related to the practical management of the condition under consideration, taking into account the need for individualized therapies. The book is published within the ISGE Book Series, a joint venture between the International Society of Gynecological Endocrinology and Springer and is based on the 2014 International School of Gynecological and Reproductive Endocrinology Winter Course. It will be an important tool for obstetricians and gynecologists, endocrinologists and experts in women's health as well as interested GPs.

Representing the most relevant procedures and technologies aiding the advance of the field of HPV-mediated carcinogenesis of the cervix and other anatomical regions of squamocolumnar transition, such as the anorectum, penis, and oropharynx, Cervical Cancer: Methods and Protocols compiles a detailed collection of practical chapters. The first half of the book covers HPV types, pathogenesis of cervical cancer (CxCA), prevention, and novel potential drug targets, while the second half explores pathology, genomics, modeling of CxCA, and experimental therapeutic strategies. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and vital, Cervical Cancer: Methods and Protocols serves as a valuable resource to both bench scientists and clinicians who step into the realm of high-risk HPVs and CxCA for the first time or those who wish to learn novel approaches or expand their toolbox for the study of CxCA.

This authoritative volume describes the role of free radicals and antioxidants in prenatal and perinatal disorders currently explored in clinical and pre-clinical trials. In twenty-two inclusive chapters, the book covers the gamut of oxidative stress and its relation to a variety of factors, including fertility, metabolism, redox biomarkers, antioxidant defense and protection, gene polymorphisms, angiogenesis, cell signaling, mutations and oxidative damage involving lipids, proteins and nucleic acids, membrane trafficking, inflammation, mitochondrial dysfunction, alterations in immunological function, hypoxia, and post-natal stressors. This comprehensive source will keep clinicians and research scientists up-to-date on translational research into medical applications. Perinatal and Prenatal Disorders is a significant addition to the well-known Oxidative Stress in Applied Basic Research and Clinical Practice series.

This book offers a critical review of the pelvic sciences-past, present and future-from an anatomical and physiological perspective and is intended for researchers, medical practitioners and paramedical therapists in the fields of urology, gynecology and obstetrics, proctology, physiotherapy, as well as for patients. The book starts with a "construction plan" of the pelvis and shows its structural consequences. The historical background of pelvic studies proceeds from medieval and early Italian models to the definitive understanding of the pelvic anatomy in the Seventeenth century. During these eras of pelvic research, concepts and approaches developed that are illustrated with examples from comparative anatomy and from mutations, also with regard to the biomechanics of pelvic structures. Perceptions of the pelvis as an important element in sexual arousal and mating conduct are discussed, as well as attitudes to circumcision, castration and other mutilations, in its anthropological, social context. The anatomy and physiology of the pelvic wall and its organs as well as the development of these pelvic organs are covered as a prerequisite to understanding, for example, the spread of pelvic carcinoma and male and female bladder muscle function. Connective pelvic tissue is examined in its reinforcing capacity for pelvic structures, but also as a "hiding place" for infections. Innervations and reflexes relayed through the pelvic nerves are discussed in order to explain incontinence, sphincter function and the control of smooth and striated muscles in the pelvis. Catheters and drugs acting on pelvic function are described, and a critical review of alternative clinical methods for treating pelvic dysfunctions is provided.

Publisher's Note: Products purchased from Third Party sellers are not guaranteed by the publisher for quality, authenticity, or access to any online entitlements included with the product. Introducing the definitive gynecologic oncology reference and surgical atlas-in one essential text. A Doody's Core Title for 2019! Gynecologic Oncology: Clinical Practice and Surgical Atlas brings together a skill-sharpening reference and full-color atlas to deliver an unmatched introduction to the field. As the most comprehensive, evidence-based gynecologic oncology resource available, this all-in-one resource offers high-yield coverage of the discipline's underlying principles and proven management strategies. Each topic is written by experts and is presented in an easily accessible, consistent presentation that highlights clinical practice guidelines, along with the diagnosis and treatment of specific malignancies. This authoritative coverage is reinforced by the state-of-the-art surgical atlas, which offers a richly illustrated, overview of essential procedures designed to build your knowledge and confidence. FEATURES Consistent, streamlined presentation for each disease consists of: Epidemiology, Pathology, Clinical Presentation, Diagnosis, Staging, Treatment, Survival, Key management strategies Thorough examination of basic gynecological oncology topics, including epidemiology, clinical trial design, biostatistics, genetics and biology of gynecologic cancers, and diagnostic modalities Instructive, A-to-Z coverage of disease sites-from cervical cancer and gestational trophoblastic disease, to epithelial ovarian cancers and breast cancer-emphasizes evidence-based practice guidelines and critical supporting data In-depth, hands-on look at clinical management topics provides an up-to-date survey of perioperative and critical care; the principles of chemotherapy, radiation therapy, and immunotherapies; and quality of care and quality of life Full-color design filled with more than 600 figures, tables, algorithms, color photos, and illustrations Key points helpfully review the main topics to be covered in specific chapters, while chapter conclusions offer convenient summaries of each chapter's core concepts Chapter-ending references underscore the book's evidence-based approach