This volume focuses on the human exposures and medical effects studies in the SemipaiatinskJ Altai region of Siberia that were a consequence of the radioactive fallout from nuclear test explosions that took place at the Semipalatinsk Test Site of the former Soviet Union. It contains a detailed account of a NATO Advanced Research Workshop (ARW) devoted to the subject, and a selection of the papers presented. The title of the ARW was "Long-term Consequences of Nuclear Tests for the Environment and Population Health (SemipaiatinskJAltai Case Studies)." The estimated exposures to large numbers of people in the Altai lie in an important dose rate and dose domain. Hence the research reported herein provides new and unique information on the effects of radiation on humans. Also emphasized at the ARW were studies involving fallout from the Pacific Island tests of the U. S. A . . There have been over 2300 nuclear weapon test explosions to date. More than 500 took place in the atmosphere and outer space; the remainder were underground. The atmospheric tests comprise the largest source of anthropogenic radioactivity released into the earth's atmosphere to date. The vast majority, in number and yield, were carried out by the former Soviet Union (FSU) and the United States. Each superpower maintained two primary test sites, one continental primarily for small yield tests, and the other more remote for larger yield tests. For the U. S. A.

This book examines the policy and politics of two health risks, which have recently become prominent social issues in many countries. One is the issue of asbestos as an environmental risk to humans, and another is that of bovine spongiform encephalitis (BSE), or mad cow disease as an animal disease, and of its variant Creutzfeldt-Jakob disease (CJD) as a human food risk. Employing a set of analytical frameworks in political science, each case study explores how the issues emerged, agendas got set, alternatives were chosen, and policies were implemented. Through the analysis, it is examined how safety and public reassurance were pursued in the countries studied (Japan, the UK, France the USA, and Korea). Exploration of the successes and failures in their efforts discloses the key elements to successful health risk management.

Biological markers used to assess the effects of environmental pollution have attracted considerable attention from regulatory agencies and are currently under evaluation at a number of research facilities throughout the world. However promising a biomarker-based biomonitoring approach may be, the development of this concept is complicated by a range of technical issues. This book provides a conceptional framework for research and application of biomarkers. International experts on biomonitoring have formulated a unified strategy for the development and validation of biomarkers in assessing environmental health as well as appropriate protocols for their implementation and interpretation in a biological monitoring program.

This volume, written by a range of international experts, covers a wide range of topics involving organic fluorine compounds. Each chapter is preceded by a summary and includes extensive illustrations and references. The chapters cover atmospheric chemistry, application of 19F NMR, partition, degradation and transformation, naturally occurring organic fluorine compounds, toxicology of perfluoroalkanes and phosphorofluoridates, and application of aromatic compounds to the elucidation of the mechanism of cytochrome P450.

Transport and mobility are essential parts of the current organization of society. Complex activities are interwoven in such a way that problems occurring from the actual process of constant movement cannot be separated, as they are so tightly interconnected.

This book examines the health effects of transport and mobility by addressing the major issues related to the subject and analyzing their consequences. Thus not only are air pollution, noise, and sedentarism and its related endocrine problems discussed, but topics such as jet-lag, accidents and violent displacement are also addressed. The strength of this book over others in the field lies in its multidisciplinary approach to the issues by a number of experts in different scientific fields who are documenting the health effects of transport and mobility. Moreover, it enhances the understanding of the issues by integrating information from different geographical regions.

Audience: Presented in a comprehensive manner, this book is useful as both grassroots, background information and state-of-the art knowledge to a wide range of readers, including experts and non-experts alike, professionals in both environmental and health sciences, decision-makers, research scientists, journalists, and post-graduate students.

Aimed at students taking a course on visual perception, this textbook considers what it means for a man, a monkey and a computer to perceive the world. After an introduction and a discussion of methods, the book deals with how the environment produces a physical effect, how the resulting "image" is processed by the brain or by computer algorithms in order to produce a perception of "something out there." It also discusses color, form, motion, distance, and also the sensing of three dimensionality, before dealing with visual perception and its role in awareness and consciousness. The book concludes with discussions of perceptual development, blindness, and visual disorders. Visual perception is by its very nature an interdisciplinary subject that requires a basic understanding of a range of topics from diverse fields, and this is a very readable guide to all students whether they come from a neuroscience, psychology, cognitive science, robotics, or philosophy background.

This book grew out of an effort to salvage a potentially useful idea for greatly simplifying traditional quantitative risk assessments of the human health consequences of using antibiotics in food animals. In 2001, the United States FDA's Center for Veterinary Medicine (CVM) (FDA-CVM, 2001) published a risk assessment model for potential adverse human health consequences of using a certain class of antibiotics, fluoroquinolones, to treat flocks of chickens with fatal respiratory disease caused by infectious bacteria. CVM's concern was that fluoroquinolones are also used in human medicine, raising the possibility that fluoroquinolone-resistant strains of bacteria selected by use of fluoroquinolones in chickens might infect humans and then prove resistant to treatment with human medicines in the same class of antibiotics, such as ciprofloxacin. As a foundation for its risk assessment model, CVM proposed a dramatically simple approach that skipped many of the steps in traditional risk assessment. The basic idea was to assume that human health risks were directly proportional to some suitably defined exposure metric. In symbols: Risk = K x Exposure, where "Exposure" would be defined in terms of a metric such as total production of chicken contaminated with fluoroquinolone-resistant bacteria that might cause human illnesses, and "Risk" would describe the expected number of cases per year of human illness due to fluoroquinolone-resistant bacterial infections caused by chicken and treated with fluoroquinolones."

The purpose of this book is to investigate the suitability and applicability of available methods for analyzing the human and ecological risks involved in the release of genetically-modified microorganisms. Main topics include: - risk analysis and assessment; approach to safety assurance; - inventory of available scientific risk assessment methods for biotechnology; - identification of methodology gaps and research needs in biology, ecology or other disciplines; - development of a general framework to guide future biotechnology risk assessment efforts; - international regulatory activities.

Radionuclides produced by past nuclear weapon test explosions comprise the largest source of anthropogenic radioactivity released into the earth's atmosphere to date. This volume presents data and models about the fate of the released radionuclides and their possible effects on human health. It is divided into the following three parts:
- Source Term Studies;
- Dose Reconstruction;
- Ecological and Health Effects,
and comprises both Western and formerly secret Soviet research studies, illuminates past and current research.

Reviews of Environmental Contamination and Toxicology attempts to provide concise, critical reviews of timely advances, philosophy and significant areas of accomplished or needed endeavor in the total field of xenobiotics, in any segment of the environment, as well as toxicological implications.

Did you know that high levels of toxins in the human body can be linked to common conditions such as infertility, obesity, rheumatoid arthritis, heart disease, and diabetes? With therapeutic guidance designed for clinicians, Clinical Environmental Medicine focuses on how toxins such as arsenic, lead, mercury and organophosphates have become one of the leading causes of chronic disease in the industrial world. The first edition of this text describes how to treat these undesirable elements and molecules that can poison enzyme systems, damage DNA, increase inflammation and oxidative stress, and damage cell membranes. Expert authors Walter Crinnion and Joseph E. Pizzorno offer practical guidance for assessing both total body load as well as specific toxins. In addition, evidence-based treatment procedures provide recommendations for decreasing toxin exposure and supporting the body's biotransformation and excretion processes. NEW! Unique! Practical diagnostic and therapeutic guidance designed for clinicians. NEW! Unique! Coverage of the most common diseases for which toxins are a primary cause. NEW! Description of how each toxin causes damage provides insights into sources, body load, and interventions for each toxin. NEW! Unique! Entirely evidence-based content focuses on the most common conditions from which patients suffer. NEW! Unique! Coverage of environmental toxicants, endogenous toxicants, and "toxins of choice" focuses on non-industrially-exposed populations.

This volume addresses a broad spectrum of the environmental issues surrounding organic bromine and iodine compounds. It covers their partition among the environmental compartments and the potential for their long-range dissemination. The important issue of their atmospheric chemistry is discussed in detail in the context of ozone depletion and global warming, and the significant difference between the reactions of methyl bromide and methyl iodide are underscored. The mammalian toxicity is discussed and the mechanisms of the degradation and transformation of organic bromine and iodine compounds addressed. There has been considerable interest in naturally occurring metabolites in the current debate on the fate and partition of methyl bromide that is an important fungicide and is produced in substantial quantities as a metabolite of marine algae. The possible natural occurrence of diphenyl ethers that are used as flame retardants have also been raised. A discussion is given on plausible mechanisms for the biosynthesis of representative organic bromine and organic iodine metabolites. Reaction pathways are illustrated throughout and comprehensive references are given.

In 2004 an amount of 187 tons of palladium has been sold in world market. The main demands were automotive catalyst (58%), electronics (14%), jewellery (14%) and dental practises (13%). Especially, the increasing use of palladium in catalytic converters is a reason for substantial research in this field. Emission, environmental distribution and possible health effects of pla- num have been summarized detailed in two recent books "Emissionen von Platinmetallen: Analytik, Umwelt- und Gesundheitsrelevanz" and "Anth- pogenic Platinum Group Emissions - Their Impact on Man and Envir- ment" published by Springer in 1999 and 2000 (Zereini & Alt (Eds)). But there is a clear lack of information concerning palladium. It is very imp- tant to condense the present state of research findings from emission to potential health risks for the environment and humans. Very important is the chapter about analytical determination of pal- dium, which shows clearly the problems of several analytical techniques. Some data published during the last decade have to be re-evaluated because of insufficient analytical techniques. Also the finding that palladium c- pounds are relatively soluble and mobile in environmental settings is a great issue for further investigations. I think it is the right time for such a comprehensive book about palladium research and I am sure that readers with different scientific background like chemists, biologists, geologists medical doctors e.g. will benefit very much from reading this book.

Since the mid 1990s, legal action to eliminate persistent organic pollutants (POPs) has started resulting in a global Convention on POPs, the Stockholm Convention, and a regional Protocol under the Convention on Long-Range Transboundary Air Pollution (UN-ECE LRTAP Convention). POPs are characterized by long half-lives, persistence in the environment, they undergo long-range transport, accumulate in the environment and in biota, and they are toxic. The combination of these characteristics makes them a threat at the global level. This book makes the reader familiar with the goals of these two conventions, lays out characteristics of these compounds, presents results from case studies and addresses inventories, levels in humans and the environment as well as technologies to destroy them.

More than 30-year operational satellite data have already been used for monitoring land, ocean and atmosphere. These applications have contributed to improve sustainable economy, produce healthy environment and enhance human life. The Advanced Research Workshop sponsored by NATO and organized by the USA's National Oceanic and Atmospheric Administration and Ukrainian's Space Agency bring the scientists with the most mature research designed for practical use. The goals were to select those which is used for services today and identify the areas to expand research and services. Scientific and application results of the Workshop presented in this book can be used today in agriculture, forestry, water resources, healthy coastal life and fisheries, climate and land cover change, anthropogenic activities and others. The presented papers provide information on how to use operational satellites and in situ measurements for early detection of large-scale droughts, floods and fires, diagnose crop and pasture annual losses, predict periods with health/unhealthy vegetation based on such climate forcing events as ENSO, monitor air quality and geomagnetic activities, assess land cover trends in responce to global warming etc. The available satellite/ground information and method is currently warn with a lead time sufficient to respond, recover and protect.

In recent years, increasing attention and resources have been brought to bear on the relationship between the environment and congenital diseases. These diseases were previously thought to be mostly due to genetic causes. Even though the importance of genes as factors in causation is accepted, environmental factors seem to be implicated just as strongly. This book explores some further concepts that have arisen from more recent perceptions of environmental effects and their possible interactions with living systems. Amongst the topics discussed are:

-effects of prenatal exposure to toxic chemicals

-intra-uterine exposure to drugs

-effects of endocrine disrupters

-environmental risk and sex ratio in newborns

-surveillance of environmental impact

-research and policy

Discussion and presentation of old and novel ideas is targeted at developing a more holistic and united perception of the interaction between congenital diseases and the environment.

This volume contains the Proceedings of the XVIIth ISAC Meeting held in Valladolid, Spain, July 1-5, 2008. As such, it contains the most permanent records of the combined efforts of all attendants. The meeting was held at the School of Medicine of Valladolid, that had the privilege of a recent celebration. The celeb- tion was none other than its 600th anniversary, implying that all participants were surrounded by historical landmarks, from the historical building of the University, to the Museum of polychrome sculpture of Valladolid, to the Monastery of Clarisas in Tordesillas, to the beauty and charm of Salamanca. In this ambience we had three days of intense work, distributed in several oral sessions, preceded by plenary lectures given by our invited speakers who were kind enough to provide us with the latestprogressintheirspeci c elds. We also hadtimeallottedtoposterviewing. As regularattendantsto the XVIIth ISACMeeting, we want to expressourappreciation forthevaluablediscussionssurroundingeachposter, theenthusiasticpresentationof data, the comments of colleagues with suggestions for improvement, and the plans for collaborations that emerged from these discussions. Needless to say that XVIIth ISAC Meeting was the fruit of many collabo- tive efforts. The Local Organizing Committee pro ted from the advice of several colleagues from around the world, namely, Prof. Chris Peers from Leeds, UK, Prof. Prem Kumar from Birmingham, UK, Prof. Nanduri Prabhakar from Chicago, USA, Prof. Colin Nurse from Hamilton, Canada, and Prof. Rodrigo Iturriaga from Santiago, Chile

This book reviews recent trends and developments in the study of the impact that the environment has on human reproduction. It thoroughly examines these issues, using the most modern techniques and methods available, to analyze the manner in which both male and female fertility can be affected and assessed. Coverage examines such diverse factors as toxic environmental contaminants, air pollution, and exposure to medical drugs.

The automobile is one of the inventions that has made a decisive contribution to human mobility, and consequently it has become an inseparable part of modern human society. However, it is through this widespread use that its negative impacts on the environment have become so highly visible. Achievements in improving the ecological characteristics of the automobile are highly impressive: a modern car emits only a fraction of the amounts of noise and exhaust pollutants produced by its predecessors 30 years ago. The contributions to this book were written by experts, most of whom have been actively involved in the development of modern automobiles and their combustion engines for more than 30 years. They have participated in all phases of the ecological development of the automobile and summarize their experience and know-how in this book .

Heavy metals can be emitted into environment by both natural and anthropogenic sources, mainly mining and industrial activity. Human exposure occurs through all environmental media. Infants are more susceptible to the adverse effects of exposure. Increasing attention is now being paid to the mental development of children exposed to heavy metals. The purpose of this book is to evaluate the existing knowledge on intellectual impairment in children exposed to heavy metals in their living environment and to identify the research needs in order to obtain a clearer picture of the situation in countries and regions at risk, in which the economy is closely related to metallurgy and heavy metals emission, and to recommend a strategy for human protection. In greater detail the main objectives could be formulated as follows: to review the principal sources of single, and complex mixtures of, heavy metal pollutants in the environment; to identify suitable methodology for chemical analyses in the environment and in humans; to evaluate the existing methods for measuring mental impairment, including their reliability and validity; to recommend a standard testing protocol to be used in future research; to assess the future role of environmental heavy metal pollution in countries and regions at risk and its effects on children's neurological development; to recommend a prevention strategy for protecting children's health and development.

In Risk Analysis of Complex and Uncertain Systems acknowledged risk authority Tony Cox shows all risk practitioners how Quantitative Risk Assessment (QRA) can be used to improve risk management decisions and policies. It develops and illustrates QRA methods for complex and uncertain biological, engineering, and social systems - systems that have behaviors that are just too complex to be modeled accurately in detail with high confidence - and shows how they can be applied to applications including assessing and managing risks from chemical carcinogens, antibiotic resistance, mad cow disease, terrorist attacks, and accidental or deliberate failures in telecommunications network infrastructure. This book was written for a broad range of practitioners, including decision risk analysts, operations researchers and management scientists, quantitative policy analysts, economists, health and safety risk assessors, engineers, and modelers.

Environmental Chemistry is a relatively young science. Interest in this subject, however, is growing very rapidly and, although no agreement has been reached as yet about the exact content and limits of this interdisciplinary discipline, there appears to be increasing interest in seeing environmental topics which are based on chemistry embodied in this subject. One of the first objectives of Environ mental Chemistry must be the study of the environment and of natural chemical processes which occur in the environment. A major purpose of this series on Environmental Chemistry, therefore, is to present a reasonably uniform view of various aspects of the chemistry of the environment and chemical reactions occurring in the environment. The industrial activities of man have given a new dimension to Environ mental Chemistry. We have now synthesized and described over five million chemical compounds and chemical industry produces about hundred and fifty million tons of synthetic chemicals annually. We ship billions of tons of oil per year and through mining operations and other geophysical modifications, large quantities of inorganic and organic materials are released from their natural deposits. Cities and metropolitan areas of up to 15 million inhabitants produce large quantities of waste in relatively small and confined areas. Much of the chemical products and waste products of modern society are released into the environment either during production, storage, transport, use or ultimate disposal. These released materials participate in natural cycles and reactions and frequently lead to interference and disturbance of natural systems."

This book presents the latest research in quantifying complex mixtures in the environment and analyzing their potential impact on human health. Many of the manuscripts reported in these proceedings represent the most up-to-date measurements of population exposures in Central and Eastern Europe. These studies are of value to health and environmental professionals around the world as they develop strategies for assessing exposures, remediating contaminated environments, and improving public health.

The quality of food is such a live issue at the moment that this title is an essential tool for researchers in a variety of disciplines. It provides a review of the key features of trace elements in soils, plants and the food web on which human beings survive. The authors' intention is to summarize up-to-date interdisciplinary data for the concise presentation of our understanding of trace-element transfer in the chain from soil to man.

Every person on our home planet is affected by a worldwide deluge of man-made chemicals and pollutants - most of which have never been tested for safety. Our chemical emissions are six times larger than our total greenhouse gas emissions. They are in our food, our water, the air we breathe, our homes and workplaces, the things we use each day. This universal poisoning affects our minds, our bodies, our genes, our grandkids, and all life on Earth. Julian Cribb describes the full scale of the chemical catastrophe we have unleashed. He proposes a new Human Right - not to be poisoned. He maps an empowering and hopeful way forward: to rid our planet of these toxins and return Earth to the clean, healthy condition which our forebears enjoyed, and our grandchildren should too.