This book will focus on DNA and histone methylation in epigenetics and describe how it is involved in the molecular mechanisms responsible for the development of cancer. Chapters will summarize the current knowledge of the molecular basis of DNA and histone methylation and explain how it is involved in cancer, describe the features of DNA and histone methylation associated with particular types of cancer, diagnostic/therapeutic applications, and future directions of DNA and histone methylation as cancer targets.

Bioinformatics Algorithms: Design and Implementation in Python provides a comprehensive book on many of the most important bioinformatics problems, putting forward the best algorithms and showing how to implement them. The book focuses on the use of the Python programming language and its algorithms, which is quickly becoming the most popular language in the bioinformatics field. Readers will find the tools they need to improve their knowledge and skills with regard to algorithm development and implementation, and will also uncover prototypes of bioinformatics applications that demonstrate the main principles underlying real world applications.

Pioneers in Medicine and Their Impact on Tuberculosis tells the stories of six individuals [Laennec, Koch, Biggs, von Pirquet, Frost, and Waksman], each of whom made significant contributions to their own respective medicalfields, as well as to the overall battle to conquer tuberculosis. Throughout history, tuberculosis has been at or near the top of the list of infectious diseases that have plagued humankind. This pervasive disease has had a central position not only in causing illness but also in challenging medical scientists to understand it -- and, in so doing, to further understand all of human health and illness. Pioneers in Medicine and Their Impact on Tuberculosis tells the stories of six of these individuals: Rene Theophile Hyacinthe Laennec [pathology], Heinrich Hermann Robert Koch [bacteriology], Hermann Michael Biggs [public health], Clemens von Pirquet [immunology], Wade Hampton Frost [epidemiology], and Selman Abraham Waksman [antibiotics]. Itexamines not only their contributions in their own fields but also their special work in conquering tuberculosis. Presenting their fascinating lives and the seminal work they did in their disciplines, the author examines the importance of their discoveries and relates them to the dramatic expansion of medical science during the era in which they lived. Thomas M. Daniel is Professor Emeritus of Medicine and International Health and Emeritus Director of the Center for International Health at Case Western Reserve University. His previous book, Captain of Death: The Story of Tuberculosis [University of Rochester Press, 1997] was "strongly recommended" by the NewEngland Journal of Medicine, and was selected by Choice for its Outstanding Academic Book List for 1998.

Unique and timely volume as mRNA is a hot area of research making great strides. Covers the full-scale production systems that are needed to develop vaccines as well as elements of data needed to secure the IND approvals. Introduces a commercial-scale manufacturing process using novel techniques like the PCR, in addition to the traditional plasmid DNA. First book that offers commercial technology for developing and large-scale supply of mRNA products. Renowned author and entrepreneur in the field of drug discovery and production.

Principles of Clinical Cancer Research provides comprehensive coverage of the fundamentals of clinical cancer research, including the full spectrum of methodologies used in the field. For those involved in research or considering research careers, this book offers a mix of practical advice and analytical tools for effective training in theoretical principles as well as specific, usable teaching examples. The clinical oncologist or trainee will find a high-yield, practical guide to the interpretation of the oncology literature and the application of data to real-world settings. Valuable for both researchers and clinicians who wish to sharpen their skills, this book contains all the cornerstones and explanation needed to produce and recognize quality clinical science in oncology.Written from the physician-scientist's perspective, it lays a strong foundation in pre-clinical sciences that is highly relevant to careers in translational oncology research along with coverage of population and outcomes research and clinical trials. It brings together fundamental principles in oncology with the statistical concepts one needs to know to design and interpret studies successfully. With each chapter including perspectives of both clinicians and scientists, Principles of Clinical Cancer Research provides balanced, instructive, and high-quality topic overviews and applications that are accessible and thorough for anyone in the field. Key Features: Gives real-world examples and rationales behind which research methods to use when and why Includes numerous tables featuring key statistical methods and programming commands used in everyday clinical research Contains illustrative practical examples and figures in each chapter to help the reader master the main concepts Provides tips and pointers for structuring a career, avoiding pitfalls, and achieving success in the field of clinical cancer research Access to fully downloadable ebook

Music recommendation systems are becoming more and more popular. The increasing amount of personal data left by users on social media contributes to more accurate inference of the user's musical preferences and the same to quality of personalized systems. Health recommendation systems have become indispensable tools in decision making processes in the healthcare sector. Their main objective is to ensure the availability of valuable information at the right time by ensuring information quality, trustworthiness, authentication, and privacy concerns. Medical doctors deal with various kinds of diseases in which the music therapy helps to improve symptoms. Listening to music may improve heart rate, respiratory rate, and blood pressure in people with heart disease. Sound healing therapy uses aspects of music to improve physical and emotional health and well-being. The book presents a variety of approaches useful to create recommendation systems in healthcare, music, and in music therapy.

"True wellness innovation requires the recruitment of multi-disciplinary participants. This book breaks the mold with examples from healthcare experts and other professionals who have leveraged informatics to better the lives of their constituents." - Jason Helgerson, Founder & CEO, Helgerson Solutions Group LLC Developed for those training in academic centers as well as for those already "out in the field," this book looks at how attorneys, behavioral health experts, business development experts, chief information officers, chief medical officers, chief nursing information officers, consumer advocates, cryptographic experts, futurists, geneticists, informaticists, managed care executives, nurses, pharmacists, physicians, public health professionals, software developers, systems security officers, and workforce experts are collaborating on a "team-based," IT-enabled approach to improve healthcare.

A unique point of this book is its low threshold, textually simple and at the same time full of self-assessment opportunities. Other unique points are the succinctness of the chapters with 3 to 6 pages, the presence of entire-commands-texts of the statistical methodologies reviewed and the fact that dull scientific texts imposing an unnecessary burden on busy and jaded professionals have been left out. For readers requesting more background, theoretical and mathematical information a note section with references is in each chapter. The first edition in 2010 was the first publication of a complete overview of SPSS methodologies for medical and health statistics. Well over 100,000 copies of various chapters were sold within the first year of publication. Reasons for a rewrite were four. First, many important comments from readers urged for a rewrite. Second, SPSS has produced many updates and upgrades, with relevant novel and improved methodologies. Third, the authors felt that the chapter texts needed some improvements for better readability: chapters have now been classified according the outcome data helpful for choosing your analysis rapidly, a schematic overview of data, and explanatory graphs have been added. Fourth, current data are increasingly complex and many important methods for analysis were missing in the first edition. For that latter purpose some more advanced methods seemed unavoidable, like hierarchical loglinear methods, gamma and Tweedie regressions and random intercept analyses. In order for the contents of the book to remain covered by the title, the authors renamed the book: SPSS for Starters and 2nd Levelers. Special care was, nonetheless, taken to keep things as simple as possible, simple menu commands are given. The arithmetic is still of a no-more-than high-school level. Step-by-step analyses of different statistical methodologies are given with the help of 60 SPSS data files available through the internet. Because of the lack of time of this busy group of people, the authors have given every effort to produce a text as succinct as possible.

This invaluable volume serves as a guide to up-to-the-minute techniques for the discovery and evaluation of pharmacologically active compounds for therapeutic development. Focusing on practical applications, provided by expert practitioners from both industry and academic research laboratories, Advances in Drug Discovery Techniques covers rational drug design, high-throughput screening and genetic approaches to drug discovery. Moreover, chapters also focus on advances in the use of combinatorial chemistry and natural products, both of which support the chemical diversity for many drug screening programmes. Typical screening studies and their link to robotics and informatics are also presented in detail, together with an overview of current progress within antisense therapeutics. Overall, this book will be an excellent reference source for all individuals interested in making sense of the rapid changes in drug discovery that result from developments in molecular biology, robotics and informatics.

This book discusses normal sex-related differences in lung structure and function and the role these differences play in lung disease. New research on the effects of sex hormone signaling on specific cell types of the lung has begun to reveal how these hormones may drive or prevent lung disease. Expertly written chapters examine the effects of sex hormones on normal pulmonary structure and function, hormone signaling in lung health, and specific diseases such as chronic obstructive pulmonary disease, asthma, pulmonary hypertension, and lung cancer. Gender, Sex Hormones, and Respiratory Disease: A Comprehensive Guide focuses on our current understanding and the gaps in research, with suggestions for future directions and implications for therapy. This book is a useful reference for pulmonologists and researchers and will prompt further inquiry aimed at improving overall lung health.

Lung diseases are leading causes of death and disability globally, with about 65 million people suffering from COPD, and 334 million from asthma. Each year, tens of millions of people develop and can die from lung infections such as pneumonia and TB. Systemic inflammation may induce and exacerbate local inflammatory diseases in the lungs, and local inflammation can in turn cause systemic inflammation. There is increasing evidence of the coexistence of systemic and local inflammation in patients suffering from asthma, COPD, and other lung diseases, and the co-morbidity of two or more local inflammatory diseases often occurs. For example, rheumatoid arthritis frequently occurs together with, and promotes the development of, pulmonary hypertension. This co-morbidity significantly impacts quality of life, and can result in death for some patients. Current treatment options for lung disease are neither always effective, nor condition-specific; there is a desperate need for novel therapeutics in the field. Additionally, the molecular and physiological significance of most major lung diseases is not well understood, which further impedes development of new treatments, especially in the case of coexistent lung diseases with other inflammatory diseases. Great progress has been made in recent years in many areas of the field, particularly in understanding the molecular geneses, regulatory mechanisms, signalling pathways, and cellular processes within lung disease, as well as basic and clinical technology, drug discovery, diagnoses, treatment options, and predictive prognoses. This is the first text to aggregate these developments. In two comprehensive volumes, experts from all over the world present state-of-the-art advances in the study of lung inflammation in health and disease. Contributing authors cover well-known as well as emerging topics in basic, translational, and clinical research, with the aim of providing researchers, clinicians, professionals, and students with new perspectives and concepts. The editors hope these books will also help to direct future research in lung disease and other inflammatory diseases, and result in the development of novel therapeutics.

The Eighth Annual Research Conference of the American Institute for Cancer Research, held in Washington, D.C., September 3-4, 1998, was on the subject "Colon Cancer Prevention: Dietary Modulation of Cellular and Molecular Mechanisms," with participants representing various disciplines interested in this area. One of the speak ers provided an appropriate quote from 17th century physician Thomas Adams: "Pre vention is better than healing because it saves the labor of being sick," which aptly describes the need for the prevention of cancer. An overview of normal and abnormal colonic development emphasized that although the typical human colon undergoes 1013 cell divisions by age 60, with the asso ciated possibilities for error, relatively few colon tumors develop. Since dietary modu lation leads to extremely small changes in colonic cells over a long period, animal models are useful to time, observe, and delineate the events associated with colon cancer. In the development colon cancer, the inactivation of the adenomatous polyposis coli (Apc) gene is one of the earliest known events. Normally Apc downregulates the cellular protein beta-catenin, but this is lost during cancer development. Beta-catenin may itself be an oncogene; it has a short half-life, but it is stabilized by binding to is more prevalent in the cell nucleus, the gene shuttles caherin. Although the Apc between the nucleus and the cytoplasm."

The function of human white cells is dependent on a complex machinery involving a network of proteins. Their identification has posed a puzzle for scientists for many years and this book comprises the proceedings of the latest in a series of international meetings that have identified many of these entities and studied their function and clinical importance. Leucocyte Typing VII provides the definitive reference for all those working with antibodies recognising marker molecules on white blood cells. Sorting and tracing white blood cells is important in a range of clinical settings, but especially in the diagnosis of leukaemias. There is a concerted action by regulatory bodies looking for a standard against which these 'biologicals' can be assessed. The book contains the assembled work of many laboratories worldwide which jointly evaluated many hundered different monoclonal antibodies. The results of the collaborative effort reported at the meeting are published in Leucocyte Typing VII. A unique feature of this book is the complete guide to all available CD- antigens. This book is the standard reference for immunologists, cell and molecular biologists, haematologists, and pathologists working on white cell differentiation. It provides immunologists and biochemists with an up to date summary of the current knowledge of molecular aspects of different categories of human white cells (and endothelial and red cells) and provides hematologists and oncologists with information relevant to their clinical practice and research.

In recent years, inorganic polymers have attracted much attention in nano-biomedicine, in particular in the area of regenerative medicine and drug delivery. This growing interest in inorganic polymers has been further accelerated by the development of new synthetic and analytical methods in the field of nanotechnology and nanochemistry. Examples for biomedical inorganic polymers that had been proven to exhibit biomedical effects and/or have been applied in preclinical or clinical trials are polysilicate / silica glass (such as naturally formed "biosilica" and synthetic "bioglass") and inorganic polyphosphate. Some members of the mentioned biomedical inorganic polymers have already been applied e.g. as "bioglass" for bone repair and bone tissue engineering, or they are used in food processing and in dental care (inorganic polyphosphates). However, there are a number of further biological and medicinal properties of these polymers, which have been elucidated in the last few years but not yet been applied for treatment of humans. In addition to polysilicates and polyphosphate, there are a series of other inorganic polymers including polyarsenate and polyvanadate, whose biological / biomedical properties have been only marginally studied so far. Moreover, the combined application of inorganic polymers and organic polymeric molecules (formation of organic-inorganic hybrid materials) provides a variety of new materials with novel property combinations and diverse applications in nanomedicine. The planned book summarizes the present state of knowledge on a large group of inorganic polymers that had hitherto been mainly considered with regard to their chemistry but not comprehensively reviewed with respect to their potential biomedical applications.

This textbook consists of ten chapters, and is a must-read to all medical and health professionals, who already have basic knowledge of how to analyze their clinical data, but still, wonder, after having done so, why procedures were performed the way they were. The book is also a must-read to those who tend to submerge in the flood of novel statistical methodologies, as communicated in current clinical reports, and scientific meetings. In the past few years, the HOW-SO of current statistical tests has been made much more simple than it was in the past, thanks to the abundance of statistical software programs of an excellent quality. However, the WHY-SO may have been somewhat under-emphasized. For example, why do statistical tests constantly use unfamiliar terms, like probability distributions, hypothesis testing, randomness, normality, scientific rigor, and why are Gaussian curves so hard, and do they make non-mathematicians getting lost all the time? The book will cover the WHY-SOs.

Key Features: 1. Describes the development of the randomized, controlled trial as the gold standard of proof. 2. Unravels the meaning of "randomized," "double-blind" and "p-values" in a simplified manner for students and clinicians. 3. Contains timeless information on how medical evidence can be understood.

Computer Vision for Assistive Healthcare describes how advanced computer vision techniques provide tools to support common human needs, such as mental functioning, personal mobility, sensory functions, daily living activities, image processing, pattern recognition, machine learning and how language processing and computer graphics cooperate with robotics to provide such tools. Users will learn about the emerging computer vision techniques for supporting mental functioning, algorithms for analyzing human behavior, and how smart interfaces and virtual reality tools lead to the development of advanced rehabilitation systems able to perform human action and activity recognition. In addition, the book covers the technology behind intelligent wheelchairs, how computer vision technologies have the potential to assist blind people, and about the computer vision-based solutions recently employed for safety and health monitoring.

This volume describes the identification of emerging organic pollutants, mainly from industrial sources, their associated toxicological threats, and the latest green methods and biotechnological solutions to abate harmful impacts on people and the environment. The chapters present reviews on current applied toxicology research, occupational health hazards and green remedial solutions for pollution control in terrestrial and aquatic environments, with the aim of raising public awareness of these issues and providing chemists, toxicologists and environmental scientists with the knowledge to combat organic pollutants through sustainable means. Readers will learn about the multi-dimensional applications of materials and processes which harvest energy out of environmental remediation technologies, as well as the roles of biotechnology and nanotechnology in addressing high pollutant load. Specific attention is paid to technologies that draw energy through wastewater remediation, as this covers the primary means by which organic pollutants are introduced into the environment from industry and other sources. The book will be of use to pollution control boards, industry regulators, and students and researchers in the fields of biotechnology, biomedical science, hydrology and water chemistry.

The impairment of lung function caused by environmental exposure to pollutants and toxicants is a rising health problem, particularly in highly industrialized parts of the world. The problem is urgently calling for the development of new methodologies to assess both the level of elemental exposure and the effects for quality of health and longevity. This volume provides state-of-the-art information about the recent advances in occupational and non-occupational pollutant-related disorders of the respiratory tract, and the assessment of a threat they pose for the health-span. Heavy traffic-related air pollution, unnoticeable but salient health detriment, is dealt with at length.

All About Bioinformatics: From Beginner to Expert provides readers with an overview of the fundamentals and advances in the field of bioinformatics, as well as future directions. Each chapter is didactically organized and includes an introduction, applications, tools and future directions. The book covers both traditional topics such as biological databases, algorithms, genetic variations, static methods, and structural bioinformatics, as well as contemporary advanced topics such as high throughput technologies, drug informatics, system and network biology, and machine learning. This is a valuable resource for researchers and graduate students who are interested in learning more about bioinformatics to apply tactics in their research work.

This volume provides a comprehensive collection of classical and cutting edge protocols and techniques to examine the normal development and physiological functions of the gastrointestinal system and to model the most common digestive diseases. The chapters focus on diverse research topics including ex vivo systems to study gastrointestinal development and functions, in vivo imaging of the gastrointestinal tract, isolation and characterization of intestinal immune cells, and animal models of gastrointestinal inflammation and cancer. The Gastrointestinal Physiology and Diseases: Methods and Protocols book targets wide audience of physiologists, cell and developmental biologists, immunologists, and physician-scientists working in the field of gastroenterology and beyond. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Highly practical and clearly written, Gastrointestinal Physiology and Diseases: Methods and Protocols will serve both seasoned researchers as well as newcomers to the field and will provide a unique resource and expert guidance to modern laboratory techniques developed for examining normal functions and diseases of the gastrointestinal tract.

This first edition volume demystifies the complex topic of flow cytometry by providing detailed explanations and nearly 120 figures to help novice flow cytometry users learn and understand the bedrock principles necessary to perform basic flow cytometry experiments correctly. The book divides the topic of flow cytometry into easy to understand sections and covers topics such as the physics behind flow cytometry, flow cytometry lingo, designing flow cytometry experiments and choosing appropriate fluorochromes, compensation, sample preparation and controls and ways to assess cellular function using a variety of flow cytometry assays. Written as a series of chapters whose concepts sequentially build off one another, using the list of materials contained within each section along with the readily reproducible laboratory protocols and tips on troubleshooting that are included, readers should be able to reproduce the data figures presented throughout the book on their way to mastering sound basic flow cytometry techniques. Easy to understand and comprehensive, Flow Cytometry Basics for the Non-Expert will be a valuable resource to novice flow cytometry users as well as experts in other biomedical research fields who need to familiarize themselves with a basic understanding of how to perform flow cytometry and interpret flow cytometry data. This book is written for both scientists and non-scientists in academia, government, biotechnology, and medicine.

The concepts of telemedicine and e-healthcare have eased as well as improved the reachability of experienced doctors and medical staff to remote patients. A patient who is living in a remote village area can directly connect to specialist doctors across the globe though his/her mobile phone using telemedicine systems and e-healthcare services. In pandemic situations like COVID-19, these online platforms helped society to get medical treatment from their residence without any physical movement. Technology is transforming human lives by playing an important role in the planning, designing, and development of intelligent systems for better service. This book presents a cross-disciplinary perspective on the concept of machine learning, blockchain and IoT by congregating cutting-edge research and insights. It also identifies and discusses various advanced technologies such as internet of things (IoT), big data analytics, machine learning, artificial intelligence, cyber security, cloud computing, sensors and so on that are vital to foster the development of smart healthcare and telemedicine systems by providing effective solutions to the medical challenges faced by humankind.

Hundreds of eponyms are used within the field of immunology-Petri dish, Crohn's disease, Bence Jones protein, Kupffer cells, Freund's adjuvant, Ouchterlony immunodiffusion, to name just a few-but most of us don't know much about the individuals who gave their names to these terms. Where were they born and educated, what other accomplishments are they credited with, why has history chosen to remember them, or not? This book presents the first comprehensive collection of immunologic eponyms, and through them tells the story of this fascinating field, from its earliest beginnings to present day. Organized by surname and meticulously cross-referenced and indexed, this book offers historical anecdotes and little-known facts which scientists, clinicians, students, and general readers will find captivating and memorable. A one-of-a-kind introduction to immunology that serves as both a history lesson and current reference on the diseases, treatments, and individuals who have been crucial to this field.

Growth in the pharmaceutical market has slowed down - almost to a standstill. One reason is that governments and other payers are cutting costs in a faltering world economy. But a more fundamental problem is the failure of major companies to discover, develop and market new drugs. Major drugs losing patent protection or being withdrawn from the market are simply not being replaced by new therapies - the pharmaceutical market model is no longer functioning effectively and most pharmaceutical companies are failing to produce the innovation needed for success. This multi-authored new book looks at a vital strategy which can bring innovation to a market in need of new ideas and new products: Systems Biology (SB). Modeling is a significant task of systems biology. SB aims to develop and use efficient algorithms, data structures, visualization and communication tools to orchestrate the integration of large quantities of biological data with the goal of computer modeling. It involves the use of computer simulations of biological systems, such as the networks of metabolites comprise signal transduction pathways and gene regulatory networks to both analyze and visualize the complex connections of these cellular processes. SB involves a series of operational protocols used for performing research, namely a cycle composed of theoretical, analytic or computational modeling to propose specific testable hypotheses about a biological system, experimental validation, and then using the newly acquired quantitative description of cells or cell processes to refine the computational model or theory.