For the average person, genetic testing has two very different faces. The rise of genetic testing is often promoted as the democratization of genetics by enabling individuals to gain insights into their unique makeup. At the same time, many have raised concerns that genetic testing and sequencing reveal intensely personal and private information. As these technologies become increasingly available as consumer products, the ethical, legal, and regulatory challenges presented by genomics are ever looming. Assembling multidisciplinary experts, this volume evaluates the different models used to deliver consumer genetics and considers a number of key questions: How should we mediate privacy and other ethical concerns around genetic databases? Does aggregating data from genetic testing turn people into products by commercializing their data? How might this data reduce or exacerbate existing healthcare disparities? Contributing authors also provide guidance on protecting consumer privacy and safety while promoting innovation.

The concept of smart drug delivery vehicles involves designing and preparing a nanostructure (or microstructure) that can be loaded with a cargo, this can be a therapeutic drug, a contrast agent for imaging, or a nucleic acid for gene therapy. The nanocarrier serves to protect the cargo from degradation by enzymes in the body, to enhance the solubility of insoluble drugs, to extend the circulation half-life, and to enhance its penetration and accumulation at the target site. Importantly, smart nanocarriers can be designed to be responsive to a specific stimulus, so that the cargo is only released or activated when desired. In this volume we cover smart nanocarriers that respond to externally applied stimuli that usually involve application of physical energy. This physical energy can be applied from outside the body and can either cause cargo release, or can activate the nanostructure to be cytotoxic, or both. The stimuli covered include light of various wavelengths (ultraviolet, visible or infrared), temperature (increased or decreased), magnetic fields (used to externally manipulate nanostructures and to activate them), ultrasound, and electrical and mechanical forces. Finally we discuss the issue of nanotoxicology and the future scope of the field.

In the last few years, several "bottom-up" and "top-down" synthesis routes have been developed to produce tailored hybrid nanoparticles (HNPs). This book provides a new insight into one of the most promising "bottom-up" techniques, based on a practical magnetron-sputtering inert-gas-condensation method. A modified magnetron-sputtering-based inert-gas-condensation (MS-IGC) system is presented, and its performances under different conditions are evaluated. Designed for graduate students, researchers in physics, materials science, biophysics and related fields, and process engineers, this new resource fills a critical need to understand the fundamentals behind the design and tailoring of the nanoparticles produced by the MS-IGC method. It shows that the morphology, the size and the properties of the nanoparticles can be modulated by tuning the deposition parameters such as the energy, the cooling rate, and the collision and coalescence processes experienced by the nanoparticles during their formation. The mechanisms of formation of different HNPs are suggested, combining the physico-chemical properties of the materials with the experimental conditions. This book illustrates the potential of MS-IGC method to synthesize multifunctional nanoparticles and nanocomposites with accurate control on their morphology and structure. However, for a better understanding of HNPs formation, further improvements in characterization methods of aggregation zone conditions are needed. In addition, the optimization of the yield and harvesting process of HNPs is essential to make this method sufficiently attractive for large-scale production.

Whether you are a doctor, nurse, student, or otherwise interested reader, the stories here will help you to understand how medicine works and how medical error can happen. The lifelong process of learning that is a medical career requires healthcare workers to find a way to live through these setbacks without either becoming too adept at putting them 'down to experience' and forgetting their social significance, or 'burning out' and leaving medicine. The stories and discussions here present detailed narratives, analyses, and reflections on medical errors through actions, omissions, and misunderstandings. They offer a uniquely honest perspective on the social implications of medical error and will enable healthcare workers at all levels to analyse and learn from it without losing sight of its impact.

Physician assisted suicide occurs when a terminally ill patient takes the decision to end their life with the help of their doctor. In this book the authors argue clearly and forcefully for the legalization of physician assisted suicide.

This important volume is the first to address the use of neuroimaging in civil and criminal forensic contexts and to include discussion of prior precedents and court decisions. Equally useful for practicing psychiatrists and psychologists, it reviews both the legal and ethical consideraitons of neuroimaging.

In the last three decades, the human body has gained increasing prominence in contemporary political debates, and it has become a central topic of modern social sciences and humanities. Modern technologies - such as organ transplants, stem-cell research, nanotechnology, cosmetic surgery and cryonics - have changed how we think about the body. In this collection of thirty original essays by leading figures in the field, these issues are explored across a number of theoretical and disciplinary perspectives, including pragmatism, feminism, queer theory, post-modernism, post-humanism, cultural sociology, philosophy and anthropology. A wide range of case studies, which include cosmetics, diet, organ transplants, racial bodies, masculinity and sexuality, eating disorders, religion and the sacred body, and disability, are used to appraise these different perspectives. In addition, this Handbook explores various epistemological approaches to the basic question: what is a body? It also offers a strongly themed range of chapters on empirical topics that are organized around religion, medicine, gender, technology and consumption. It also contributes to the debate over the globalization of the body: how have military technology, modern medicine, sport and consumption led to this contemporary obsession with matters corporeal? The Handbook's clear, direct style will appeal to a wide undergraduate audience in the social sciences, particularly for those studying medical sociology, gender studies, sports studies, disability studies, social gerontology, or the sociology of religion. It will serve to consolidate the new field of body studies.

The effective delivery of healthcare services is vital to the general welfare and well-being of a country's citizens. Financial infrastructure and policy reform can play a significant role in optimizing existing healthcare programs. Health Economics and Healthcare Reform: Breakthroughs in Research and Practice is a comprehensive source of academic material on the importance of economic structures and policy reform initiatives in modern healthcare systems. Highlighting a range of pertinent topics such as clinical costing, patient engagement, and e-health, this book is ideally designed for medical practitioners, researchers, professionals, and students interested in the optimization of healthcare delivery.

The Patient Self-Determination Act of 1990 required medical facilities to provide patients with written notification of their right to refuse or consent to medical treatment. Using this Act as an important vehicle for improving the health care decisionmaking process, Lawrence P. Ulrich explains the social, legal, and ethical background to the Act by focusing on well-known cases such as those of Karen Quinlan and Nancy Cruzan, and he explores ways in which physicians and other caregivers can help patients face the complex issues in contemporary health care practices. According to Ulrich, health care facilities often address the letter of the law in a merely perfunctory way, even though the Act integrates all the major ethical issues in health care today. Ulrich argues that well-designed conversations between clinicians and patients or their surrogates will not only assist in preserving patient dignity - which is at the heart of the Act - but will also help institutions to manage the liability issues that the Act may have introduced. He particularly emphasizes developing effective advance directives. Ulrich examines related issues, such as the negative effect of managed care on patient self-determination, and concludes with a seldom-discussed issue: the importance of being a responsible patient. Showing how the Patient Self-Determination Act can be a linchpin of more meaningful and effective communication between patient and caregiver, this book provides concrete guidance to health care professionals, medical ethicists, and patient-rights advocates.

To what extent should parents be allowed to use reproductive technologies to determine the characteristics of their future children? And is there something morally wrong with parents who wish to do this? Choosing Tomorrow's Children provides answers to these (and related) questions. In particular, the book looks at issues raised by selective reproduction, the practice of choosing between different possible future persons by selecting or deselecting (for example) embryos, eggs, and sperm.
Wilkinson offers answers to questions including the following. Do children have a 'right to an open future' and, if they do, what moral constraints does this place upon selective reproduction? Should parents be allowed to choose their future children's sex? Should we 'screen out' as much disease and disability as possible before birth, or would that be an objectionable form of eugenics? Is it acceptable to create or select a future person in order to provide lifesaving tissue for an existing relative? Is there a moral difference between selecting to avoid disease and selecting to produce an 'enhanced' child? Should we allow deaf parents to use reproductive technologies to ensure that they have a deaf child?

Since Dolly the sheep was born, controversy has swirled around the technology of cloning. We recoil at the prospect of human copies, manufactured men and women, nefarious impersonators and resurrections of the dead. Such reactions have serious legal consequences: lawmakers have banned stem cell research along with the cloning of babies. But what if our minds have been playing tricks on us? What if everything we thought we knew about human cloning is rooted in intuition rather than fact? Human Cloning: Four Fallacies and their Legal Consequences is a rollicking ride through science, psychology and the law. Drawing on sources ranging from science fiction films to the Congressional Record, this book unmasks the role that psychological essentialism has played in bringing about cloning bans. It explains how hidden intuitions have caused conservatives and liberals to act contrary to their own most cherished ideals and values.

Death comes for us all, and the desire to ease into that death is as ancient as humankind. The idea that sometimes it is better to die quickly and in control of that death--rather than linger in pain and misery once impending death is certain--has troubled yet comforted humankind. In Doctor, Please Help Me Die, author Tom Preston, MD, presents a thorough overview and discussion of end-of-life issues and physician-assisted death in America.

Doctor, Please Help Me Die traces the history of patients seeking relief from suffering at the end of life and discusses how cultural and professional customs have inhibited many doctors from helping their patients at the end. Preston shows how most doctors fail their patients by not discussing dying with them and by refusing to consider legal physician aid in dying--ultimately deceiving the public in their refusal to help patients die. He discusses the religious, political, and legal battles in this part of the culture war and gives advice to patients on how to gain peaceful dying.

Preston presents a strong argument for why every citizen who is dying ought to be extended an inalienable right to die peacefully, and why every physician has an ethical obligation to assist patients who want to exercise this right safely, securely, and painlessly.