Natural products that have both plant growth regulatory properties and pharmaceutical properties are examined in this book. This is the first and most up-to-date text linking agrochemistry and pharmaceutical chemistry in an easy to read presentation for practitioners in both fields.

Due to the intense and widespread attention being given to the undesirable side-effects of commercial herbicide products such as residual contamination, resistance, ecosystem impairments, and waste generation, the discovery of new, natural herbicides that are biologically safe will prove to be significant and profitable.

Featuring over 200 tables, Biologically Active Natural Products: Agrochemicals is very useful to those in the agrochemical and pharmaceutical industries, as well as those in biochemistry, plant pathology, and natural products study and development.

Features

The third edition of the Toxicologist's Pocket Handbook, like the first two editions, is a scaled-down version of the best-selling Handbook of Toxicology. It provides the most frequently used toxicology reference information in a convenient pocket-sized book. The format remains the same as the earlier editions to allow basic reference information to be located quickly, with the information placed in sections specific to subspecialties of toxicology. A detailed table of contents lists all tables and figures contained in the book by section. This expanded edition contains a number of tables not found in the second edition added to sections on lab animals, general toxicology, dermal and ocular toxicology, genetic toxicology/carcinogenesis, neurotoxicology, immunotoxicology, reproductive/developmental toxicology, industrial chemical, and pharmaceutical toxicology. New information is presented for additional laboratory animals such as swine and primates, infusion recommendations, newer methods such as the local lymph node assay, and reference safety pharmacology values for standard species. Additional information on typical genetic toxicology and immunotoxicology assays as well as in vitro assays for eye irritation are provided. Some tables from the second edition have been updated to include new information that has arisen since the earlier edition went to press. Information from the second edition, such as regulatory requirements that are no longer applicable, has been deleted.

Covering a wide range of research currently being done in drug analysi s, Drug Testing Technology: Assessment of Field Applications compares and evaluates various methods used to determine abused drugs taken by individuals, and their application in various programs and contexts. Controversies associated with various methods, including urine analysi s and hair analysis, are examined. Contributors from a wide diversity of disciplines offer advanced knowledge, encompassing work which is te chnical as well as markedly philosophical. Chapters provide overviews of drug incorporation into hair; the use of hair analysis for complia nce measurement in the use of anti-epileptic medications; and the appl ication of drug testing to the psychiatric treatment of substance abus e disorders. Drug Testing Technology: Assessment of Field Application s provides information useful in medical applications, workplace testi ng, criminal justice monitoring community epidemiology, and drug treat ment assessment.

Protein phosphorylation via protein kinases is an inevitable process that alters physiological and pathological functions of the cells. Thus, protein kinases play key roles in the regulation of cell life or death decisions. Protein kinases are frequently a driving factor in a variety of human diseases including aging and cellular senescence, immune system and endothelial dysfunctions, cancers, insulin resistance, cholestasis and neurodegenerative diseases, as well as bacterial resistance in persistent infections. Recent developments in quantitative proteomics provide important opinions on kinase inhibitor selectivity and their modes of action in the biological context. Protein Kinase-mediated Decisions Between Life and Death aims to have the reader catch insights about up-to-date opinions on "Protein Kinases" related pathways that threaten human health and life. As "Protein Kinases" are related to many health problems, clinicians, basic science researchers and students need this information. Chapter "Signal Transduction in Immune Cells and Protein Kinases" is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

Following the success of the first two volumes in Stahl's Case Studies series, a brand new collection of clinical stories have been collated in Volume 3, derived from cases seen by medical students, residents and faculty from the University of California at Riverside (UCR) Department of Psychiatry and Neuroscience. The highly popular and unique user-friendly presentation of previous volumes has been maintained, with extensive use of icons, questions/answers, and tips. The cases address multifaceted issues in an understandable way and with direct relevance to the everyday experience of clinicians. Covering a wide-ranging and representative selection of clinical scenarios, each case is followed through the complete clinical encounter, from start to resolution, acknowledging all the complications, issues, decisions, twists and turns along the way. The book is about living through the treatments that work, the treatments that fail, and the mistakes made along the journey. This is psychiatry in real life.

The sixth volume in the series Medicinal and Aromatic Plants -Industrial Profiles, written by experts working in ergot research. Ergot (claviceps purpura) is best known as a disease of rye and grasses. it is probably the most widely cultivated fungus and it has become an important field crop. Ergot alkaloids, which are extensively used in medicine, are the main reason for its importance.;This work begins with the history of ergot research which is comparable to that of the discovery of penicillin. review articles on claviceps taxonomy, genetics, biogenetic and pharmacology are based on recent achievements in molecular biology - some of them published there for the first time. The chapters on ergot cultivation, physiology and biotechnology are written by experts in industry. Sections dealing with the chemistry of ergot alkaloids and biotransformation are comprehensive and serve as good reference material.;Unique information on world producers and industrial production of ergot alkaloids and their derivatives is detailed. The therapeutic use of ergot alkaloids is presented; and the dangers of their use in ecology and agriculture are discussed in detail.

An up-to-date treatment of the scientific and commercial aspects of this increasingly popular medicinal plant genus, this volume covers material written by tea tree specialists dealing with significant aspects of "M. alternifolia", including botany, chemistry, cultivation, agronomy, processing, toxicology, bioactivity, uses and marketing. Cajuput ("M. cajaputi"), Niaouli ("M. quinquenervia") and potentially commercial "Melaleucas" are also reviews. The book is aimed at those concerned with the study and uses of medicinal and aromatic plants and provides a comprehensive and contemporary overview of the status of tea tree.

Natural Products in Vector-Borne Disease Management explores the potential application of natural products in vector control and disease management. The chapters discuss the global impact of specific vector-borne diseases, gaps in management, and natural products in specific stages of development - discovery, optimization, validation, and preclinical/clinical development. Toxic effects and mechanisms of action are also discussed. This book also explores how therapeutic plant derivatives can be used to combat the vectors of infection and how natural products can be used to manage and treat vector-borne diseases like malaria, leishmaniasis, dengue, and trypanosomiasis. With the inclusion of case studies on field and clinical applications and the contributions from experts in the field, Natural Products in Vector-Borne Disease Management is an essential resource to researchers, academics, and clinicians in parasitology, virology, microbiology, biotechnology, pharmacology, and pharmacognosy working in the field of vector-borne diseases.

The rapid development and the growing penetration of information and communication technologies (ICT) provide tremendous opportunities for a wide and cost effective application of the ideas of participative democracy and public participation in government decision and policy making. ICT can drive dramatic transformations in the quantity and quality of communication and interaction of government organizations with citizens, revitalizing and strengthening the modern representative democracy which currently faces big problems of reduced citizens' trust and involvement. This book deals with the application of these e-participation ideas in the special and 'difficult', and at the same time highly interesting, national context of Southern Europe and the Balkans. The first chapter provides an overview of e-participation concepts and practices whilst the following chapters analyse pilot applications of e-participation concepts in eight different Southern European and Balkan countries (Spain, France, Italy, Slovenia, Serbia, Albania, Greece, Yugoslav Republic of Macedonia (FYROM)). They cover both the 'classical' e-participation paradigm, based on official e-participation spaces created, operated and controlled by government organizations as well as emerging new e-participation paradigms including e-participation based on web 2.0 social media, and 'scientific-level' e-participation, based on opening government data to the scientific community. This book was originally published as a special issue of the Journal of Balkan and Near Eastern Studies.

Nationally, toxicology programs have evolved from a traditional exploration of the chemistry and applied toxicity of chemicals and drugs to a more comprehensive study of toxicology and toxicology testing as independent entities. Consequently, the second edition of Principles of Toxicology Testing starts with basic toxicological principles, including absorption, distribution, metabolism, and elimination of toxins, including chemicals and drugs. The book then continues with animal (in vivo) and in vitro toxicology testing methods associated with toxicological analysis and preclinical drug development. As in the first edition, the book begins with an introduction into the fundamentals of toxicology (Section I) to prepare readers for the subsequent topics and continues through with a discussion of toxicokinetics and human risk assessment. This introductory material is useful in understanding the applications of toxicology testing. Section II describes the fundamental principles of toxicology testing in animals in greater detail. This section describes acute toxicity studies as well as subchronic and chronic studies performed on animals. Special emphasis is placed on study design and determination of classical indicators for acute and chronic testing, such as the LD50. The book examines other short- and long-term animal toxicity testing methodologies, including dermal, ocular, and reproductive toxicity testing. In addition, mutagenicity and carcinogenicity studies are also discussed in separate chapters. Section III introduces and discusses in vitro alternatives to animal toxicology tests. This section emphasizes cell culture methodology and cellular methods for acute systemic toxicity, target organ toxicity, and local toxicity. The contributors present the advantages and disadvantages of alternative methods. They also describe the use of high-throughput screening and its applications, the concepts of standardizatio

Contents:
1. Ethical and Regulatory Approval for Human Studies A. Warbick-Cerone 2. Instrumentation, Imaging, Data Analysis and Display A.C. Perkins 3. Good Manufacturing Practice in the Preparation of Pharmaceutical Dosage Forms for Scintigraphic Evaluation M. Frier 4. Drug Delivery to the Respirotory Tract J.G. Hardy 5. Scintigraphic Study of Oesphagael Transit and Retention R.J. Dansereau, R.N. Danserau and J.W. McRorie 6. Scintigraphic Study of Drug Delivery to the Stomach and Small Bowel N. Washington and C.G. Wilson 7. Scintigraphic Study of Colonic Release and Absorption J.M. Hebden, A.C. Perkins and R.C. Spiller 8. Scintigraphic Study of Ocular Drug Delivery C.G. Wilson, Y.P. Zhu and M. Frier 9. Scintigraphic Study of Drug Carriers and Conjugates M.V. Pimm

An up-to-the-minute reference guide for health professionals confronting pulmonary disorders in children, Pediatric Asthma offers the latest findings on this classification-defying disease and related conditions. Written by more than 20 international experts in the field, the book focuses on drug administration-issues of compliance, aerosol delivery, and pharmacokinetic differences among children-with a view toward developing new and more efficacious therapies.
Provides cutting-edge analysis for more effective diagnosis of children with asthma and improved monitoring and treatment for chronic patients
With a firm theoretical grounding and reflecting the state of the art in pharmacological research and development, Pediatric Asthma
reviews the prevalence, causes, and demographics of childhood asthma worldwide
explores determinants of the disorder in various populations-gender, age and severity of onset, atopic status, family history, and smoking
elucidates physiological factors such as airway remodeling, airway hyperresponsiveness, and persistent inflammation
describes in vivo and in vitro testing for asthma-associated allergy and the pros and cons of allergen immunotherapy
delineates the dynamics of the lung in terms of phenomena such as peak expiratory flow (PEF), forced vital capacity (FVC), and bronchial hyperresponsiveness (BHR)
highlights the importance of patient education and self-management
investigates the role that developmental psychopathologies and neurobehavioral dysfunctions may play in pediatric asthma
discusses inflammatory mediators such as cytokines, chemokines, leukotrienes, and prostaglandins
evaluates intravenous and inhaled 2 agonists for the bronchodilating treatment of acute severe asthma
and more
Featuring over 2100 references, more than 60 user-friendly tables, and a handy Appendix on clinical monitoring of childhood asthma and recommended drug dosages for its treatment, Pediatric Asthma is an indispensable resource for pediatricians, pediatric pulmonologists, and pediatric pharmacists; clinical allergists and immunologists; general and family practitioners; and graduate and medical school students in these disciplines.

Poppy, the third volume in the series Medicinal and Aromatic Plants - Industrial Profiles presents up-to-date information on Poppy and related species. The introduction emphasizes the importance of Poppy, giving a historical evaluation. in the chapters describing the botany and taxonomy of the genus some novel aspects are discussed, e.g., special morphological, structural differentiation. The chapters concerning the physiology and cultivation of Poppy and alternative raw materials give a detailed presentation of this complex issue. Beyond the detailed analysis of ecological factors affecting the accumulation of opiates, both the basic methods of illicit and licit cultivation are discussed. in this volume, for the first time, an evaluation of the Australian Poppy production is presented. Also discussed are the pharmalogical effectiveness and application of opiates, as well as the international control of their processing and trade, and the modern approach to compiling both the chemical and biotechnological information concerning poppy.
This comprehensive treatment of Poppy should be of interest to everyone involved in medicinal plant research.

This text provides a concise and comprehensive introduction to key immunotoxicological issues for all those interested in, but with no prior knowledge of, this area of toxicology. The first section explores the health consequences of immunotoxicity, namely the adverse effects related to chemically-induced immunosuppression and immunostimulation, hypersensitivity reactions and autoimmune diseases, with an overview of major immunotixicants. The second part describes the latest methods used to detect and evaluate, preclinically and clinically, the unexpected immunotoxic effects of xenobiotics. Trends in implementing strategies and recent changes to the regulatory aspects are also considered. The third section examines possible future developments, including "in vitro" methods, biomarkers of immunotixicity and risk assessment.

This text provides a concise and comprehensive introduction to key immunotoxicological issues for all those interested in, but with no prior knowledge of, this area of toxicology. The first section explores the health consequences of immunotoxicity, namely the adverse effects related to chemically-induced immunosuppression and immunostimulation, hypersensitivity reactions and autoimmune diseases, with an overview of Major Immunotoxicants. The Second Part Describes The Latest Methods Used to detect and evaluate, preclinically and clinically, the unexpected Immunotoxic Effects Of Xenobiotics. Trends In Implementing Strategies And recent changes to the regulatory aspects are also considered. The third section examines possible future developments, including In Vitro Methods, Biomarkers Of Immunotixicity And Risk Assessment.

eBook available with sample pages: 0203362551

Haschek and Rousseaux's Handbook of Toxicologic Pathology, recognized by many as the most authoritative single source of information in the field of toxicologic pathology, has been extensively updated to continue its comprehensive and timely coverage. The fourth edition has been expanded to four separate volumes due to an explosion of information in this field requiring new and updated chapters. Completely revised with a number of new chapters, Volume 1, "Principles and the Practice of Toxicologic Pathology," covers the practice of toxicologic pathology in three parts: Principles of Toxicologic Pathology, Methods in Toxicologic Pathology, and the Practice of Toxicologic Pathology. Other volumes in this work round out the depth and breadth of coverage.Volume 2 encompasses "Toxicologic Pathology in Safety Assessment" and "Environmental Toxicologic Pathology". These two sections cover the application of toxicologic pathology in developing specific product classes, principles of data interpretation for safety assessment, and toxicologic pathology of major classes of environmental toxicants. Volumes 3 and 4 provide deep and broad treatment of "Target Organ Toxicity", emphasizing the comparative and correlative aspects of normal biology and toxicant-induced dysfunction, principal methods for toxicologic pathology evaluation, and major mechanisms of toxicity. These volumes comprise the most authoritative reference on toxicologic pathology for pathologists, toxicologists, research scientists, and regulators studying and making decisions on drugs, biologics, medical devices, and other chemicals, including agrochemicals and environmental contaminants. Each volume is being published separately.

This first volume in the series provides a detailed treatment in ecotoxicology and stresses why genetics is important in understanding if and how chemical contaminants affect populations. Written by an array of international contributors from various fields covering mammals, invertebrates, fish, plants, as well as molecular ecotoxicology, this book considers both ecological/evolutionary consequences and practical implications of the interplay between chemical toxicants and the genetic population.
In broadening the understanding of ecological response, this resource ranges from molecular to classical genetics, from plant to animal, from asexual to sexual, touching on some fundamental issues of evolutionary biology. In addition, gaps in our present understanding of genetic and ecotoxicological processes and future research directions have been identified.

"Cannabis sativa" has been a source of man-mad products for over 5000 years. This book contains a series of dissertations, supported by over 700 references, on the history, ethnobotany, chemistry and analysis, and cultivation and processing of cannabis. The medicinal and non-medicinal uses of the plant and its derivates are viewed in the context of national and international legislation to define and control its use. Developments in cannabinoid pharmacology research and receptor theory are also discussed.

Written by experts in the field, this textbook examines the principles and applications of techniques used in monitoring pesticide disposition following application and in the assessment of human exposure. It approaches pesticide exposure systematically, examining both occupational and bystander exposure. Some aspects of exposure which are addressed include: aerial transport with on- and off-target loss of material; transferable or dislodgeable residues from surfaces; biomonitoring of systemating absorbed residues; epidermal desposition and absorption through the skin; and the assessment of adverse health effects including neurological and neurobehavioural endpoints of toxicity. Gaining insight into exposure characterization/assessment, the reader will be able to design experiments that monitor biological effects of exposure, develop regulatory guidelines for application practices, or protect human health.

Includes a guide for troubleshooting of film-coated products Lists trademarked ingredients and equipment for film coating Presents a checklist for a QC coating-defect reporting program This book is a complete, authoritative resource on the coating of tablets, capsules, and other solid dosage forms of therapeutic agents. Fourteen authors cover the industry's technologies. The book begins with a full discussion of the primary processes -- sugar coating, film coating, and microencapsulation -- as well as the rationale for coating, methodologies, formulations, processing methods, and equipment and cleaning. Then it explores automation of the coating process, including hardware and software requirements. Finally, the book examines major stability and quality control issues. Regulations underlie all discussions.

Create! is a Design and Technology course for Key Stage 3. It provides all the material needed to deliver the demands of the new Key Stage 3 strategy. The course follows the QCA scheme and the materials support ICT requirements. A wide range of differentiated worksheets is available on a customisable CD-ROM. The student books contain clear links to the Key Stage 3 strategy and include design-and-make assignments, product evaluations and practical tasks; each spread opens with objectives to focus the lesson, and ends with a plenary to summarise and evaluate.

Provides the only single-volume reference for stability requirement in all major markets Discusses all aspects of stability testing, including ICH stability guidelines Supports the text with real-world examples In this book, recognized industry experts and regulatory inspectors from the world's pharmaceutical manufacturing regions provide stability requirements in all the major markets and discuss all aspects of stability testing and biotechnology. Participants in the ICH debates interpret the ICH guidelines. Other discussions focus on European requirements, the ICH initiatives, the US SUPAC initiative, matrixing and bracketing approaches from the cGMP and FDA perspective, and stability requirements in Japan, Australia, and WHO. Stress programs, testing of preservatives, and physical stability topics are addressed as well as various protocols and statistical approaches.

This book provides a comprehensive summary of data from basic and clinical studies in support of a role for corticotropin-releasing factor (CRF) as a neurotransmitter in the mammalian central nervous system (CNS). It includes descriptions of the anatomy of CRF and its receptors in the CNS, as well as the characterization of CRF receptors and the second messenger systems mediating effects of CRF in the brain. It discusses the autonomic, behavioral, and electrophysiologic effects of CRF administration in the brain. This work also includes a section which covers the role of brain CRF in the etiology and pathophysiology of a variety of neurologic, psychiatric, and endocrine disorders. Endocrinologists, brain researchers, and neuroendocrinologists are among those who will find this reference both useful and interesting.

The use of drugs as remedies for various types of diseases has a long tradition; however, it has only been recently recognized that the value of any given compound must be evaluated in light of its benefit to risk ratio. When prescribing drugs, physicians must look at the big picture of the drug's benefits in relation to its side effects and possible toxicity. The aim of this handbook is to compile data from various authors, providing clinicians with data that will optimize their decision making in selecting effective, low-risk drug treatments. It also provides research workers, including physicians, pharmacists, and basic scientists, with a sound basis for increasing knowledge of the risk/benefit ratios of various drugs. Includes detailed assessments of the following types of drugs: oAntihypertensive agents oDiuretics oAnti-diabetic drugs oAnticonvulsant drugs oDrugs for Parkinson's disease oAntihistamines and antiserotonins oCytokines and immunomodulators oNon-opioid analgesics and anti-inflammatory agents oAntibacterial agents oAntiviral agents oDrugs used in reproductive endocrinology oSystemic drugs for skin diseases oTopical liposome drugs oTopical glucocorticoids

At a point where most introductory organic chemistry texts end, this problems-based workbook picks up the thread to lead students through a graduated set of 120 problems. With extensive detailed spectral data, it contains a variety of problems designed by renowned authors to develop proficiency in organic structure determination. This workbook leads you from basic problems encountered in introductory organic chemistry textbooks to highly complex natural product-based problems. It presents a concept-based learning platform, introducing key concepts sequentially and reinforcing them with problems that exemplify the complexities and underlying principles that govern each concept. The book is organized in such a way that allows you to work through the problems in order or in selections according to your experience and desired area of mastery. It also provides access to raw data files online that can be downloaded and used for data manipulation using freeware or commercial software. With its problem-centered approach, integrated use of online and digital resources, and appendices that include notes and hints, Problems in Organic Structure Determination: A Practical Approach to NMR Spectroscopy is an outstanding resource for training students and professionals in structure determination.