At a time when genetics and informatics are seen to transform therapeutic thinking once again, it is pertinent to look back to earlier therapeutic regimes. The long twentieth century has witnessed a tremendous upsurge in new drugs, remedies and therapeutic strategies. The cultural environments in which they emerged, the social circumstances from which they sprang, and the social effects that remedies engendered are treated in depth in this collection of essays. They address the historical variety of remedies as economic, social, and cultural objects and discuss their particular forms of production and distribution. Drawing predominantly on British and Dutch cases, the curious 'biographies' of modern drugs like streptomycin, taxol and interferon are reviewed, the shifting boundaries between medicines and toxic substances are explored, and remedial strategies such as contraceptives are scrutinised. This book, which emerged out of an Anglo-Dutch conference held in 1998, explores cultures of remedies from a comparative perspective.

For more than 40 years ASHP has published the most trusted resource for injectable drug information. Our new ASHP (R) Injectable Drug Information now delivers the same high-quality content that you can expect from ASHP with even more of the information you need to make decisive patient care decisions. The 2023 edition of the industry's go-to guide is newly updated with the latest information, the full list of the AHFS (R) Pharmacologic-Therapeutic Classification (c) system, multiple new monographs, and nearly 200 new references for a total of over 24,000 total compatibility pairs. ASHP (R) Injectable Drug Information (TM) 2023 features more than 400 monographs, including: Brexanolone Cefiderocol sulfate tosylate Oritavancin Oliceridine fumarate Remdesivir Remimazolam besylate Sildenafil citrate

This book addresses various clinical and sub clinical applications of antioxidant nutraceuticals, with a primary focus on preventive use for general wellness, common ailments, and such chronic illnesses as cancer and neurological applications. This unique book captures the applications of natural antioxidants, which have been used for thousands of years in Traditional Chinese Medicine and Ayurvedic Medicine as well as modern nutraceuticals formulations. It covers antioxidant applications in clinical scenarios including the historical perspective, basic antioxidant properties and applications, anti-inflammatory properties, and antioxidant applications in a variety of clinical conditions.

Ranunculales Medicinal Plants: Biodiversity, Chemodiversity and Pharmacotherapy comprehensively covers this order of flowering plants, detailing the phytochemistry, chemotaxonomy, molecular biology, and phylogeny of selected medicinal plants families and genera and their relevance to drug efficacy. The book carries out an exhaustive survey of the literature in order to characterize global trends in the application of flexible technologies. The interrelationship between Chinese species, and between Chinese and non-Chinese species, is inferred through molecular phylogeny and based on nuclear and chloroplast DNA sequencing. The book discusses the conflict between chemotaxonomy and molecular phylogeny in the context of drug discovery and development. Users will find invaluable and holistic coverage on the study of Ranunculales that will make this the go-to pharmaceutical resource.

Anthrax is only one of many biological threats. We read and hear about the others in the news: mad cow disease, shark attacks, killer bees, the West Nile virus, polluted wells-countless stories of biological hazards in the U.S. and around the world. This compact reference handbook covers everything from disease-causing viruses and bacteria, to harmful insects, poisonous plants, dangerous animals, and other types of living threats to human life. Readers will learn the nature of these hazards, the associated risks, and where to find information for further study and research. Topics include: Human Pathogens in Water Human Pathogens in Food Human Pathogens in Air Human Pathogens Transmitted by Contact Crop and Livestock Pathogens and Pests Toxins and Allergens Predators and Other Biological Hazards Hazard and Controversy. In each category, the author presents the current scientific knowledge on causes, preventive measures, costs, outlook, and other topics of interest. Historical contexts are also provided. Every chapter ends with an anecdote illustrating its major themes. Primary source documents, statistical information, and a glossary are added features that make this resource the ideal starting point for anyone interested in biological hazards.

This dictionary spans the practice of pharmacology, and of allied sciences insofar as they are related to it, with particular emphasis on the development, regulation and use of human medicine. It is offered to students as well as to professionals in pharmacology and allied sciences for "reference" and for "browsing," and as a bedside book and travelling companion. Its size (approximately 2000 entries) is appropriate for these uses.

Features of this dictionary:

- Provides definitions of terms in pharmacology, both basic and clinical

- Gives information on new medicine development and official regulations

- Covers allied topics, including statistics, ethics, scientific miscounduct, authorship, publication and law.

Multifunctional Systems for Combined Delivery, Biosensing, and Diagnostics explores how multifunctional nanocarriers are being used in combined delivery and diagnostics in contemporary medicine. Particular attention is given to efforts to i) reduce the side effects of therapeutic agents, ii) increase the pharmacological effect, and iii) improve aqueous solubility and chemical stability of different therapeutic agents. The chapters focus on applications of nanostructured materials and nanocarriers, highlighting how these can be used effectively in both diagnosis and delivery. This applied focus makes the book an important reference source for those wanting to learn more about how specific nanomaterials and nanotechnology systems can help to solve drug delivery and diagnostics problems. This book is a valuable resource for materials scientists, bioengineers, and medical researchers who are looking for an applications-oriented guide on how nanotechnology and nanomaterials can be used effectively throughout the medical treatment process, from diagnosis to treatment.

Nanostructures for Drug Delivery extensively covers the various nanostructured products that have been tested as carriers in target drug delivery systems. In addition, the book analyses the advantages of, and issues related to, using nanostructured materials in drug delivery systems, also detailing various nanocarrier preparation techniques. As delivering the drug to the target site is a major problem in providing effective treatment for many diseases, this book covers the latest advancements in numerous nanotechnological products that are being used in disease detection, controlled drug delivery, as biosensors, and in tissue engineering that have been developed for more efficient patient healthcare. Due to the versatility of nanostructured materials, it is now possible to deliver a drug at its target site in a more accurate and efficient way. This volume is an up-to-date, state-of-the-art work that highlights the principal mechanistic aspects related to the delivery of active nanoscale therapeutic agents (natural or synthetic) and their release profile in different environmental media. It highlights nanoscale encapsulation strategies and discusses both organic and inorganic nanomaterials as carriers and delivery platforms.

Nano- and Microscale Drug Delivery Systems: Design and Fabrication presents the developments that have taken place in recent years in the field of micro- and nanoscale drug delivery systems. Particular attention is assigned to the fabrication and design of drug delivery systems in order to i) reduce the side effects of therapeutic agents, ii) increase their pharmacological effect, and iii) improve aqueous solubility and chemical stability of different therapeutic agents. This book is designed to offer a cogent, concise overview of current scholarship in this important area of research through its focus on the characterization and fabrication of a variety of nanomaterials for drug delivery applications. It is an invaluable reference source for both biomaterials scientists and biomedical engineers who want to learn more about how nanomaterials are engineered and used in the design of drug delivery nanosystems.

An Introduction to Ethical, Safety and Intellectual Property Rights Issues in Biotechnology provides a comprehensive look at the biggest technologies that have revolutionized biology since the early 20th century, also discussing their impact on society. The book focuses on issues related to bioethics, biosafety and intellectual property rights, and is written in an easy-to-understand manner for graduate students and early career researchers interested in the opportunities and challenges associated with advances in biotechnology. Important topics covered include the Human Genome Project, human cloning, rDNA technology, the 3Rs and animal welfare, bioterrorism, human rights and genetic discrimination, good laboratory practices, good manufacturing practices, the protection of biological material and much more. Full of relevant case studies, practical examples, weblinks and resources for further reading, this book offers an essential and holistic look at the ways in which biotechnology has affected our global society.

Alcohol use disorder (AUD) is a major public health problem in the United States. The estimated 12-month and lifetime prevalence values for AUD are 13.9% and 29.1%, respectively, with approximately half of individuals with lifetime AUD having a severe disorder. AUD and its sequelae also account for significant excess mortality and cost the United States more than $200 billion annually. Despite its high prevalence and numerous negative consequences, AUD remains undertreated. In fact, fewer than 1 in 10 individuals in the United States with a 12-month diagnosis of AUD receive any treatment. Nevertheless, effective and evidence-based interventions are available, and treatment is associated with reductions in the risk of relapse and AUD-associated mortality. The American Psychiatric Association Practice Guideline for the Pharmacological Treatment of Patients With Alcohol Use Disorder seeks to reduce these substantial psychosocial and public health consequences of AUD for millions of affected individuals. The guideline focuses specifically on evidence-based pharmacological treatments for AUD in outpatient settings and includes additional information on assessment and treatment planning, which are an integral part of using pharmacotherapy to treat AUD. In addition to reviewing the available evidence on the use of AUD pharmacotherapy, the guideline offers clear, concise, and actionable recommendation statements, each of which is given a rating that reflects the level of confidence that potential benefits of an intervention outweigh potential harms. The guideline provides guidance on implementing these recommendations into clinical practice, with the goal of improving quality of care and treatment outcomes of AUD.

The content of this book is intended to provide the toxicologist in drug development in the pharmaceutical and biotechnology industries with a broad understanding of bone and its interactions with other organ systems in safety assessments. The book is divided into three parts. The first part describes our current understanding of bone biology and its primary regulatory pathways. Additional chapters address regulatory and study design considerations for incorporating bone end points in toxicology studies, with special consideration being given to juvenile toxicology studies. This is intended to address recent regulatory requirements to evaluate skeletal development for drugs in development for pediatric populations. The second part of the book describes the principal techniques and methods used in bone research; understanding how these end-points are derived is fundamental to their appropriate application. These first two parts of the book provide the background and the means to develop the concepts in part three which describes bone and its interaction with other organ systems. The unique series of chapters in part three, contributed to by key leaders in their respective fields and in bone research, provides a comprehensive collective work. Although constantly evolving, the crosstalk and interaction of the skeleton with several organ systems is now recognized and well documented, such as for the reproductive system, muscle and kidney, while our understanding of the interaction with other organ systems, such as the immune system and CNS, is in its infancy. Recent work highlights the key role of the skeleton in the regulation of energy metabolism and the impact this has on research in metabolic diseases such as obesity and diabetes. The hope is that this book will enlighten many and encourage more to explore the impact of new compounds on the skeleton in the development of effective and safe drugs.

In this book, the author provides expert analysis on naturally occurring iridoids, their chemistry and their distribution in plants and insects. Particular attention is given to the pharmacology of iridoids and their prospective applications in pharmaceutical and agricultural industries. Iridoids are found in a wide variety of plants and some insects, and they are structurally derived from monoterpenoid natural products. In the first two chapters of this book, the author describes the iridoids classification, occurrence and distribution in plants and insects. The following chapters cover different chromatographic and spectroscopic techniques that can be used to identify and quantify iridoids in herbal formulations, and also the biosynthesis of iridoids, in which the reader will discover a metabolomics and transcriptomics analysis to identify the genes involved in the biosynthesis. The final chapters provide insights on several pharmacological activities of iridoids, their physiological role in insects, pharmacokinetics in mammals, insects and microorganisms, and their applications in medicine and agriculture. This book will engage students and researchers interested in the chemistry of natural products, and it will also appeal to medicinal chemists and practitioners working in the design of new herbal drugs with bioactive pure iridoids.

Ion Channels Down Under, Volume 79 provides up-to-date information on ion channel pharmacology, their pharmacological modulators, and their role in a diverse range of poorly treated medical conditions. This new volume covers specific topics relating to Receptors and the Diversity in their Structure and Pharmacology, Acid-Sensing Ion Channel Pharmacology, Past, Present and Future, Sodium Channels and Venom Peptide Pharmacology, the Role of Non-Neuronal TRPV4 Signaling in Inflammatory Processes, and Genetically Encoded Calcium Indicators as Probes to Assess the Role of Calcium Channels in Disease and for High-Throughput Drug Discovery. Contributors in this series include prominent scientists and highly-recognized experts with major accomplishments in the field of ion channel pharmacology. Topics covered include the role of ion channels in health and disease, ion channels as therapeutic targets and the molecular pharmacology of ion channels.

The 'golden age' for antibiotic discovery, from 1940 until the early 1970s, ushered in a new era in human- and animal-health and the associated dramatic increase in human life expectancies. Indeed the possibility of eradicating infectious disease seemed feasible. However it soon became apparent that microorganisms wouldn't be defeated so easily. Their weapon: antibiotic resistance. Today microbial antibiotic resistance is rapidly exhausting our supply of effective compounds and making the possibility of a global public health disaster seems likely. The urgency of this situation has spawned a plethora of new multi-disciplinary research initiatives looking for novel antibiotics and other antimicrobial agents. In this timely book respected international experts summarize the most important research to provide a timely overview of the field. Opening chapters define 'antibiotic', explain why we need new compounds, outline the applications of antibiotics, both old and new, and describe the producing microbes. These are followed by chapters that cover antibiotic resistance, toxicity, overuse, new antimicrobial sources, new targets, novel technologies for antibiotic discovery (e.g. silent gene clusters), lantibiotics, natural antivirals, new macrolide derivatives, and antibiotics in the pipeline. This books is essential reading for everyone working in antimicrobial research in academia, biotechnology companies, and the pharmaceutical industry and a recommended volume for all microbiology libraries.