Radiochemical methodology constitutes the most important base for the successful functioning of a PET group in the routine production and development of radiopharmaceuticals. Of the several hundred products which have been labelled with positron emitters during the past two decades about 35 are presently considered to be of major interest. The time for a state-of-the-art review is right, since this field has advanced over the past fifteen years to reach a level where guidelines can now be suggested. Chapters of this book deal with each of the main methodological aspects of the chemistry needed to develop an effective radiopharmaceutical, namely radionuclide production, automation and metabolite analysis. A further chapter on QA/QC is written by a broadly-based expert group and is meant to provide a guideline and a base for future monographs and regulations on major PET radiopharmaceuticals of today. This book will help the increasing numbers of scientists who are now entering the field of PET to appreciate the methodological aspects that are normally addressed by chemists in relation to PET radiopharmaceuticals; it provides many useful practical guidelines and will promote early success in their own endeavours, since these will often necessarily begin by establishing chemical methodology of the kind discussed here.

Parameters such as membrane transport, metabolism and protein incorporation govern the fate of amino acids in living tissue. Is it possible to use positron tomography to measure some of them, and what is their meaning in normal and pathological situations? These questions have been addressed for a long time and no satisfactory answer has yet been given. This book, which derives from an EEC workshop organized in the frame of the Concerted Action on "PET Investigation of Cellular Regeneration and Degeneration", held in Lyon in February 1992, gives the present state of knowledge in this field based on the most recent studies. Contributions from 24 leading European and American scientists are presented and discussed.

The conference was devoted to the discussion of present and future techniques in medical imaging, including 3D x-ray CT, ultrasound and diffraction tomography, and biomagnetic ima- ging. The mathematical models, their theoretical aspects and the development of algorithms were treated. The proceedings contains surveys on reconstruction in inverse obstacle scat- tering, inversion in 3D, and constrained least squares pro- blems.Research papers include besides the mentioned imaging techniques presentations on image reconstruction in Hilbert spaces, singular value decompositions, 3D cone beam recon- struction, diffuse tomography, regularization of ill-posed problems, evaluation reconstruction algorithms and applica- tions in non-medical fields. Contents: Theoretical Aspects: J.Boman: Helgason' s support theorem for Radon transforms-a newproof and a generalization -P.Maass: Singular value de- compositions for Radon transforms- W.R.Madych: Image recon- struction in Hilbert space -R.G.Mukhometov: A problem of in- tegral geometry for a family of rays with multiple reflec- tions -V.P.Palamodov: Inversion formulas for the three-di- mensional ray transform - Medical Imaging Techniques: V.Friedrich: Backscattered Photons - are they useful for a surface - near tomography - P.Grangeat: Mathematical frame- work of cone beam 3D reconstruction via the first derivative of the Radon transform -P.Grassin, B.Duchene, W.Tabbara: Dif- fraction tomography: some applications and extension to 3D ultrasound imaging -F.A.Gr}nbaum: Diffuse tomography: a re- fined model -R.Kress, A.Zinn: Three dimensional reconstruc- tions in inverse obstacle scattering -A.K.Louis: Mathemati- cal questions of a biomagnetic imaging problem - Inverse Problems and Optimization: Y.Censor: On variable block algebraic reconstruction techniques -P.P.Eggermont: On Volterra-Lotka differential equations and multiplicative algorithms for monotone complementary problems

Since the introduction of myocardial perfusion imaging and radionuclide angiography in the mid-seventies, cardiovascular nuclear medicine has undergone an explosive growth. The use of nuclear cardiology techniques has become one of the cornerstones of the noninvasive assessment of coronary artery disease. In the past 15 years major steps have been made from visual analysis to quantitative analysis, from planar imaging to tomographic imaging, from detection of disease to prognosis, and from separate evaluations of perfusion, metabolism, and function to an integrated assessment of myocardial viability. In recent years many more advances have been made in cardiovascular nuclear imaging, such as the development of new imaging agents, reevaluation of existing procedures, and new clinical applications. This book describes the most recent developments in nuclear cardiology and also addresses new contrast agents in MRI. What's New in Cardiac Imaging will assist the clinical cardiologist, the cardiology fellow, the nuclear medicine physician, and the radiologist in understanding the most recent achievements in clinical cardiovascular nuclear imaging.

CT scanning is now an integral part of everyday diagnostic procedure, yet the imaging technique must be good if the diagnosis is to be accurated. Here is the book that shows how to guarantee good CT scans Patient preparation, slice thickness, IV contrast and other pieces to the puzzle of successful scanning are fully described. The consistent format allows easy cross referencing throughout the book. The sequences and protocols in this simple guidebook provide a sound basis which can be altered and adapted to suit individual needs. Practical CT Techniques has been written especially for radiographers, but junior radiologists working with CT for the first time will find it to be a useful introduction, too.

1. Neuroanatomy of dopaminergic system in the human brain.- 2. Radioligands for PET studies of D2-receptors: butyrophenone and ergot derivatives.- 3. Radioligands for dopamine receptor PET studies: benzamides and ligands for dopamine D-1 receptors.- 4. Monoamine precursors in PET research - biochemical issues and functional significance.- 5. Quantitation problems in positron emission tomography (PET) as applied to the kinetic analysis of the striatum dopamine data.- 6. Investigation of the dopamine system with positron emission tomography: general issues in modeling.- 7. Modelisation: application to the D2 receptors.- 8. [18F] Fluorodopa uptake in brain.- 9. Dopamine reuptake sites: the issues.- 10. Movement disorders: the clinical issues.- 11. Non-human primate models of dopamine system disorders: understanding neurodegenerative diseases and testing new therapeutic strategies.- 12. The dopamine system and mental disorders: clinical and psychopharmacological overview.- 13. D2 dopamine receptors and schizophrenia.- 14. The assessment of central D2-dopanvne receptor occupancy with positron emission tomography in long-term medicated schizophrenic patients.- 15. Measurement of dopamine receptor occupancy: clinical issues.

The 1991 International Conference on Information Processing in Medical Imaging (IPMI '91) is the twelfth in the series and was held in Wye College, part of the University of London. The purpose of IPMI is to provide a forum for the detailed examination of methodological issues in computing which are at the heart of advances in medical image formation, manipulation and interpretation. This volume presents the proceedings of IPMI '91. Full-length scientific papers describing the latest techniques and results are organized into the following nine sections: - Image formation and reconstruction - Incorporation of priors in tomographic reconstruction - Multi-modal registration - Segmentation: specific applications - Segmentation: multi-scale, surfaces and topology - Anatomical models and variability - Factor analysis - Rule based systems and learning - Image quality, display and interaction. The volume also includes a set of color plates and a subject index. The book provides an up-to-date account of current work in the expanding and fast-moving area of image processing and medical imaging, and gives an overview of work at all the key centers researching in this area. It will prove an invaluable asset to all researchers working in the area and to the libraries of organizations involved in imaging research.

The second E. C. Workshop on Ultrasonic Tissue Characterization was organized for the assessment of research goals and plans as the basis to a grant proposal for a "Concerted Action" which will be forwarded to the European Commission. It should, therefore, not only be considered as a work in progress exhibition which succeeded the former activities within the E. C. (Inventory on Tissue Characterization in Europe and first Workshop). The Steering Group invited a 1 imited group of Institutes to send its group leader and a research fel low in the entitled field, who should expose the overall research program, as wei 1 as the more specific work on tissue characterization by RF signal analysis and spectroscopy. The ultimate goal of the Workshop has been the formulation of schemes of interaction among the Institutes and individuals and the definition of cooperative research programs. The remainder of the groups and some of the groups present are working in the field of analysis and processing of cl inical A- and B-mode echograms (i. e. video signals). Because this work is more closely related to the cl inical diagnostics it was decided that for that reason no preparatory workshop was needed. In the final proposal for the Concerted Action this work wi 1 1 get ample attention. Although not many clinicians were present, their positive interest in the sophisticated analysis techniques and their contribution to the dis cussions again have been a most valuable and stimulating experience.

An essential guide to designing, conducting, and analyzing event-related potential (ERP) experiments, completely updated for this edition. The event-related potential (ERP) technique, in which neural responses to specific events are extracted from the EEG, provides a powerful noninvasive tool for exploring the human brain. This volume describes practical methods for ERP research along with the underlying theoretical rationale. It offers researchers and students an essential guide to designing, conducting, and analyzing ERP experiments. This second edition has been completely updated, with additional material, new chapters, and more accessible explanations. Freely available supplementary material, including several online-only chapters, offer expanded or advanced treatment of selected topics. The first half of the book presents essential background information, describing the origins of ERPs, the nature of ERP components, and the design of ERP experiments. The second half of the book offers a detailed treatment of the main steps involved in conducting ERP experiments, covering such topics as recording the EEG, filtering the EEG and ERP waveforms, and quantifying amplitudes and latencies. Throughout, the emphasis is on rigorous experimental design and relatively simple analyses. New material in the second edition includes entire chapters devoted to components, artifacts, measuring amplitudes and latencies, and statistical analysis; updated coverage of recording technologies; concrete examples of experimental design; and many more figures. Online chapters cover such topics as overlap, localization, writing and reviewing ERP papers, and setting up and running an ERP lab.

Nowadays we are facing numerous and important imaging problems: nondestructive testing of materials, monitoring of industrial processes, enhancement of oil production by efficient reservoir characterization, emerging developments in noninvasive imaging techniques for medical purposes - computerized tomography (CT), magnetic resonance imaging (MRI), positron emission tomography (PET), X-ray and ultrasound tomography, etc. In the CIME Summer School on Imaging (Martina Franca, Italy 2002), leading experts in mathematical techniques and applications presented broad and useful introductions for non-experts and practitioners alike to many aspects of this exciting field. The volume contains part of the above lectures completed and updated by additional contributions on other related topics.

Medical imaging of cardiovascular disease has improved rapidly with faster multislice CT angiography. The ability to visualise 3D reconstructed vascular structures has given clinicians a much better appreciation of the anatomy and the disease process. This book provides an overview of the diagnostic applications of CT virtual intravascular endoscopy (VIE) in cardiovascular disease. It is intended to fill the gap by providing a systematic overview of the diagnostic applications of VIE in cardiovascular disease. This book serves as a comprehensive piece of literature that encompasses all aspects from the technical principles of VIE image generation to diagnostic value and potential pitfalls of VIE in cardiovascular imaging. The primary motion to write this book is to provide an overview of the CT VIE in cardiovascular disease with a focus on the clinical applications and diagnostic value of this unique visualisation tool. It is expected that readers, especially clinicians will gain a good understanding of the diagnostic value of CT VIE in the diagnosis of cardiovascular disease, so that their medical practice is enhanced with use of this exciting complementary visualisation tool.

Electron microscope tomography (EMT) has emerged as the leading technique for three-dimensional (3D) structural analysis of unique complex biological specimens. This book reviews the different computational stages involved in EMT, from image acquisition to interpretation of the 3D reconstruction. The high performance computing (HPC) techniques normally used to cope with the computational demands are also described. Moreover, combining the holographic methods with the methods for digital image processing has made it possible to develop the digital holographic interference microscope (DHIM) for real-time 3D imaging of phase microscopic objects and measurement of their morphological parameters. In this book, the classical and holographic methods of phase microobject visualisation are considered. In addition, 3D imaging has become commonplace in the medical field, with its routine use in the better established institutions for pre-natal observations, diagnosis of ailments, work-up prior to surgery, recovery monitoring and many other medical procedures. This book discusses the research methodology required in the reconstruction of 3D volume and employing computer-aided diagnosis to identify various diseases. Details of the different stages of processing, along with the promising results achieved are presented. Also discussed are some considerations for future trends of 3D imaging in the medical field. Other chapters cover detailed derivations of reconstruction algorithms in 2D and modern 3D cone-beam CT (CBCT), evaluate geometric parameters of bone in 3D using CT scans or a new low-radiating device (EOS), and CT based 3D- display providing accurate preoperative visualisation and computerised risk analyses for safety margins of pancreatic- and biliary- tract tumours, as well as for the assessment of abdominal aortic aneurysms (AAA).

This atlas is a comprehensive visual reference for the use of cardiovascular computed tomography (CT) containing photomicrographs, anatomic illustrations, tables, and charts paired with extensive legends and explanations that are supplemented by extensive research, peer-reviewed articles, and textbooks. In addition to providing historical perspective and current direction for CT, this new edition of Atlas of Cardiovascular Computed Tomography 2e focuses on research involving coronary artery diseases and anomalies, congestive heart failure, atherosclerotic plaques and asymptomatic disease, as well as imaging techniques, including preparation, acquisition, and processing, involving the great vessels and carotids, the peripheral vasculature, and coronary and pulmonary veins. The increasing role of CT in the emergency room and in private cardiology practice is also reviewed thoroughly, making this an essential read for all involved in cardiac imaging, cardiology and emergency medicine.

This atlas is a comprehensive visual reference for the use of cardiovascular computed tomography (CT) containing photomicrographs, anatomic illustrations, tables, and charts paired with extensive legends and explanations that are supplemented by extensive research, peer-reviewed articles, and textbooks. In addition to providing historical perspective and current direction for CT, this new edition of Atlas of Cardiovascular Computed Tomography 2e focuses on research involving coronary artery diseases and anomalies, congestive heart failure, atherosclerotic plaques and asymptomatic disease, as well as imaging techniques, including preparation, acquisition, and processing, involving the great vessels and carotids, the peripheral vasculature, and coronary and pulmonary veins. The increasing role of CT in the emergency room and in private cardiology practice is also reviewed thoroughly, making this an essential read for all involved in cardiac imaging, cardiology and emergency medicine.

A comprehensive guide to the conceptual, mathematical, and implementational aspects of analyzing electrical brain signals, including data from MEG, EEG, and LFP recordings. This book offers a comprehensive guide to the theory and practice of analyzing electrical brain signals. It explains the conceptual, mathematical, and implementational (via Matlab programming) aspects of time-, time-frequency- and synchronization-based analyses of magnetoencephalography (MEG), electroencephalography (EEG), and local field potential (LFP) recordings from humans and nonhuman animals. It is the only book on the topic that covers both the theoretical background and the implementation in language that can be understood by readers without extensive formal training in mathematics, including cognitive scientists, neuroscientists, and psychologists. Readers who go through the book chapter by chapter and implement the examples in Matlab will develop an understanding of why and how analyses are performed, how to interpret results, what the methodological issues are, and how to perform single-subject-level and group-level analyses. Researchers who are familiar with using automated programs to perform advanced analyses will learn what happens when they click the "analyze now" button. The book provides sample data and downloadable Matlab code. Each of the 38 chapters covers one analysis topic, and these topics progress from simple to advanced. Most chapters conclude with exercises that further develop the material covered in the chapter. Many of the methods presented (including convolution, the Fourier transform, and Euler's formula) are fundamental and form the groundwork for other advanced data analysis methods. Readers who master the methods in the book will be well prepared to learn other approaches.

This up-to-date treatment of recent developments in geometric inverse problems introduces graduate students and researchers to an exciting area of research. With an emphasis on the two-dimensional case, topics covered include geodesic X-ray transforms, boundary rigidity, tensor tomography, attenuated X-ray transforms and the Calderon problem. The presentation is self-contained and begins with the Radon transform and radial sound speeds as motivating examples. The required geometric background is developed in detail in the context of simple manifolds with boundary. An in-depth analysis of various geodesic X-ray transforms is carried out together with related uniqueness, stability, reconstruction and range characterization results. Highlights include a proof of boundary rigidity for simple surfaces as well as scattering rigidity for connections. The concluding chapter discusses current open problems and related topics. The numerous exercises and examples make this book an excellent self-study resource or text for a one-semester course or seminar.

Leave no disease undetected with "MRI and CT of the Cardiovascular System," your definitive guide to magnetic resonance and computed tomography for cardiovascular health. Authored by a collaboration of international experts, this vivid, four-color third edition imparts the latest technologies in a rapidly advancing field. With topics that range from anatomy, to MR in infants and children, to risk assessment in ischemic heart disease this text includes seven new chapters to reflect the rising tide of technological discovery as it pertains to cardiology. Thanks to its expert analysis, procedural guide to implementation, and profound understanding of the recent advances in cardiovascular imagining, "MRI and CT of the Cardiovascular System" gives you all the tools necessary for powerful screening, diagnosis, and cardiovascular care.
Features:
--New chapters reflecting technological discoveries in cardiology
--Color illustrations for heightened clarity
--Companion website with fully searchable text
--Units organized by pathology and disease detection
--Fully updated information on application of MR and CT
--Up-to-date analysis of emerging multi-detector CT

This book is written for retinal specialists and clinicians with a special interest in retinal diseases. It presents a collection of images and brief annotations of the microstructures of both the normal and diseased eye captured on swept source optical coherence tomography. The swept-source OCT is a relatively new form of imaging and is able to capture structures and details which previous generations of OCT machines cannot. This type of imaging represents the forefront in ocular imaging. This second edition includes a new chapter on optic nerve conditions and more cases on eye conditions that were imaged with the SS-OCT. It also showcases the use of swept-source OCT for OCT angiography.

This book provides new research on computed tomography. Chapter One presents strategies for computer-aided designing of surgical guides for dental implant procedures based on cone beam computed tomography (CBCT). Chapter Two gives an in depth analysis of using CBCT in anatomic variations of the mandibular canal and the mental foramen. Chapter Three discusses the use of CBCT for an accurate analysis of the nasopalatine canal. Chapter Four reviews the use of CBCT to assess morphometric characteristics of the greater palatine canal. Chapter Five reviews and discusses the application of state-of-art content based image retrieval schemes in pathological risk analysis of lung computed tomography images.

Publisher's Note: Products purchased from Third Party sellers are not guaranteed by the publisher for quality, authenticity, or access to any online entitlements included with the product. EVERYTHING YOU NEED TO ACE THE ARRT (R) COMPUTED TOMOGRAPHY EXAM (CT) EXAM IN ONE COMPLETE PACKAGE! Written by an experienced program director who knows what it takes to excel, LANGE Review: Computed Tomography Examination is designed to boost confidence, test-taking skills, and knowledge for anyone preparing for the exam. Bolstered by nearly 500 registry-style questions with detailed answer explanations, this essential guide also includes valuable background material - covering everything from eligibility requirements to test-taking tips. You will also find two comprehensive practice exams within the text and online. It all adds up to the single-best way to increase your chance of success on the CT Exam. * A thorough review of patient care, imaging procedures, and physics and instrumentation distills core concepts on the registry exam * Chapter-ending practice questions assess your knowledge of essential concepts * Two comprehensive practice exams -in the book and online--to improve your confidence * Includes 495 registry-style questions with complete explanations for each answer *

Computed tomography (CT) and cone-beam computed tomography (CBCT) are useful tools for the accurate assessment of medical, dental and orthodontic patients. Traditionally, the diagnosis and treatment planning of these patients have used two-dimensional radiographs. The clinical value of CT and CBCT lies in their ability to provide comprehensive information about anatomical relationships for improved diagnosis, treatment planning and a prediction of treatment outcomes. This book includes new research from authors across the globe, with a focus on aiding researchers and practising professionals on the use of CT and CBCT.

The "PET and PET/CT Study Guide" presents a comprehensive review of nuclear medicine principles and concepts necessary for passing PET specialty board examinations. The practice questions and content are similar to those found on the Nuclear Medicine Technology Certification Board (NMTCB) exam, allowing test takers to maximize their chances of success. The book is organized by test sections of increasing difficulty, with over 650 multiple-choice questions covering all areas of positron emission tomography, including radiation safety; radionuclides; instrumentation and quality control; patient care; and diagnostic and therapeutic procedures. Detailed answers and explanations to the practice questions follow. Supplementary appendices include common formulas, numbers, and abbreviations, along with a glossary of terms for easy access by readers. The "PET and PET/CT" "Study Guide" is a valuable reference for nuclear medicine technologists, nuclear medicine physicians, and all other imaging professionals in need of a concise review of the basics of PET and PET/CT imaging.

Recent developments in the ultra-short laser technology and physics, especially at the attosecond time scale, open up new research frontiers for attoscience. This book examines the theoretical model for attophysics. The interaction of the attosecond laser pulses with slices of matter-attosecond tomography enables the description of the motion of electrons in atoms, molecules and 1D medium-graphene. The standard theory of the laser pulse-matter interaction is based on the parabolic Schrodinger equation, which leads to unphysical, infinite velocity of the thermal energy propagation. In this book, the Schrodinger equation is generalised to hyperbolic partial differential equation with finite velocity.

The principle of tomography is to explore the structure and composition of objects non-destructively along spatial and temporal dimensions, using penetrating radiation, such as X- and gamma-rays, or waves, such as electromagnetic and acoustic waves. Based on computer-assisted image reconstruction, tomography provides maps of parameters that characterize the emission of the employed radiation or waves, or their interaction with the examined objects, for one or several cross-sections. Thus, it gives access to the inner structure of inert objects and living organisms in their full complexity. In this book, multidisciplinary specialists explain the foundations and principles of tomographic imaging and describe a broad range of applications. The content is organized in five parts, which are dedicated to image reconstruction, microtomography, industrial tomography, morphological medical tomography and functional medical tomography.

Imagining the Elephant is a biography of Allan MacLeod Cormack, a physicist who was awarded the Nobel Prize for Medicine in 1979 for his pioneering contributions to the development of the computer-assisted tomography (CAT) scanner, an honor he shared with Godfrey Hounsfield. A modest genius who was also a dedicated family man, the book is a celebration of Cormack's life and work. It begins with his ancestral roots in the far north of Scotland, and then chronicles his birth and early years in South Africa, his education at the University of Cape Town (UCT) and Cambridge University, and his subsequent academic appointments at UCT and Tufts University in Boston, USA. It details his discovery of the problem at Cape Town in 1956, traces his scientific footsteps all the way to Stockholm in December 1979, and then extends the odyssey to his pursuits beyond the Nobel Prize.