This text provides a practical guide providing step-by-step protocol to design and develop vaccines. Chapters detail protocols for developing novel vaccines against infectious bacteria, viruses, fungi, and parasites for humans and animals. Volume 2: Vaccines for Veterinary Diseases includes vaccines for farm animals and fishes, vaccine vectors and production, vaccine delivery systems, vaccine bioinformatics, vaccine regulation and intellectual property. Written for the Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Vaccine Design: Methods and Protocols, Volume 2: Vaccines for Veterinary Diseases aims to ensure successful results in the further study of this vital field.

Long acting veterinary formulations play a significant role in animal health, production and reproduction within the animal health industry. Such technologies offer beneficial advantages to the veterinarian, farmer and pet owner. These advantages have resulted in them growing in popularity in recent years.

The pharmaceutical scientist is faced with many challenges when innovating new products in this demanding field of controlled release. This book provides the reader with a comprehensive guide on the theories, applications, and challenges associated with the design and development of long acting veterinary formulations. The authoritative chapters of the book are written by some of the leading experts in the field. The book covers a wide scope of areas including the market influences, preformulation, biopharmaceutics, in vitro drug release testing and specification setting to name but a few. It also provides a detailed overview of the major technological advances made in this area. As a result this book covers everything a formulation scientist in industry or academia, or a student needs to know about this unique drug delivery field to advance health, production and reproduction treatment options and benefits for animals worldwide."

The human-animal bond has evolved and diversi?ed down the ages. Dogs, cats and even horses, have long ful?lled the role of faithful companion and indeed, as exempli?ed by the introduction of seeing and hearing dogs, there may be a critical level of co-dependency between the species. In the twenty-?rst century, the animal types that are kept as pets in many parts of the world are extensive ranging from reptiles through rodents to ruminants and beyond. As would be predicted by the nature of the relationship, the approach to treatment of a companion animal is often closely aligned to that which would have been offered to their owner. However, an increasing awareness of welfare issues, such as the recognition that animals expe- ence pain and the proven bene?ts of disease prevention in intensive farming units, together with the growth in zoos and wildlife parks, has increased the likelihood of food producing and non-domesticated animals receiving medicinal products during their life-time. Although many of the individual drugs or classes of drugs administered to animals are the same as, or derived from, those given to man, the safe and effective use of drugs in animals often cannot be achieved by simply transposing knowledge of drug action on, or behaviour in, the body from one species to another. The impact of the anatomical, physiological and pathophysiological variability that spans the animal kingdom can often profoundly alter drug response.

Papich Handbook of Veterinary Drugs, 5th Edition includes concise entries for more than 550 drugs, with appendices summarizing clinically relevant information at a glance. Nineteen new drug monographs are added to this edition, and over 100 drug monographs have been updated and revised. An Expert Consult website contains more than 150 instructional handouts that may be customized and printed out for your clients. Written by clinical pharmacology expert Mark Papich, this handy reference makes it easy to find the drug data and dosage recommendations you need to treat small and large animals, right when you need it! Over 550 concise drug monographs are organized alphabetically and cross-referenced by classification, trade, and generic name, providing quick and easy access to key information for each drug including: . Generic and trade names, pronunciation, and functional classification . Pharmacology and mechanism of action . Indications and clinical uses . Precautionary information - adverse reactions and side effects, contraindications and precautions, and drug interactions - all featured in colored boxes for at-a-glance retrieval . Instructions for use . Patient monitoring and laboratory tests . Formulations available . Stability and storage . Dosage information for both small and large animals . Regulatory information Clinically relevant appendices help you determine appropriate therapeutic regimens and look up safety and legal considerations. NEW! 19 new drug monographs familiarize you with the latest drugs available for veterinary practice. UPDATED drug monographs include new information such as changes in doses, interactions, indications, adverse reactions, and contraindications. NEW! Expert Consult companion website replaces the former website and includes more than 150 customizable client information handouts for commonly prescribed drugs, including information on the prescribed drug and dosage, do's and don'ts, and possible side effects. NEW! Removal of entries for drugs that have been taken off the market.

Long acting veterinary formulations play a significant role in animal health, production and reproduction within the animal health industry. Such technologies offer beneficial advantages to the veterinarian, farmer and pet owner. These advantages have resulted in them growing in popularity in recent years. The pharmaceutical scientist is faced with many challenges when innovating new products in this demanding field of controlled release. This book provides the reader with a comprehensive guide on the theories, applications, and challenges associated with the design and development of long acting veterinary formulations. The authoritative chapters of the book are written by some of the leading experts in the field. The book covers a wide scope of areas including the market influences, preformulation, biopharmaceutics, in vitro drug release testing and specification setting to name but a few. It also provides a detailed overview of the major technological advances made in this area. As a result this book covers everything a formulation scientist in industry or academia, or a student needs to know about this unique drug delivery field to advance health, production and reproduction treatment options and benefits for animals worldwide.

"Handbook of Veterinary Pharmacology" is a clear and concise guide to pharmacology concepts and commonly used veterinary drugs. Providing a succinct overview of veterinary pharmacology, this book presents information in a user-friendly outline format to allow quick access to practical drug information. With chapters covering the basic principles, specific drugs, interactions, and legal considerations, Handbook of Veterinary Pharmacology offers up-to-date information on basic and clinical veterinary pharmacology.

As an aid to student comprehension, simple line drawings depict the mechanisms of action and study questions with explanations are included at the end of each chapter. Appendices on withdrawal times for drugs in production animals and drug dosages in domestic species are a valuable tool, allowing quick decisions on drug therapy. "Handbook of Veterinary Pharmacology" is an indispensable text for veterinary students and practitioners.

The human-animal bond has evolved and diversi?ed down the ages. Dogs, cats and even horses, have long ful?lled the role of faithful companion and indeed, as exempli?ed by the introduction of seeing and hearing dogs, there may be a critical level of co-dependency between the species. In the twenty-?rst century, the animal types that are kept as pets in many parts of the world are extensive ranging from reptiles through rodents to ruminants and beyond. As would be predicted by the nature of the relationship, the approach to treatment of a companion animal is often closely aligned to that which would have been offered to their owner. However, an increasing awareness of welfare issues, such as the recognition that animals expe- ence pain and the proven bene?ts of disease prevention in intensive farming units, together with the growth in zoos and wildlife parks, has increased the likelihood of food producing and non-domesticated animals receiving medicinal products during their life-time. Although many of the individual drugs or classes of drugs administered to animals are the same as, or derived from, those given to man, the safe and effective use of drugs in animals often cannot be achieved by simply transposing knowledge of drug action on, or behaviour in, the body from one species to another. The impact of the anatomical, physiological and pathophysiological variability that spans the animal kingdom can often profoundly alter drug response.

Learn to calculate dosages accurately and administer drugs safely! Applied Pharmacology for Veterinary Technicians, 6th Edition shows you how to determine drug dosages, administer prescribed drugs to animals, and instruct clients about side effects and precautions. Coverage of drugs includes pharmacokinetics, pharmacodynamics, clinical uses, dosage forms, and adverse effects. An Evolve companion website offers animations of pharmacologic processes, practice with dosage calculations, narrated videos demonstrating drug administration techniques, and more. Written by veterinary technology educator Lisa Martini-Johnson, this resource provides the pharmacology knowledge you need to succeed as a vet tech! Quick-access format makes it easy to find important drug information, including clinical uses, dosage forms, and adverse side effects. Body systems organization follows a logical sequence of study. Illustrated, step-by-step procedures demonstrate proper administration techniques for common drug forms. Key terms, chapter outlines, Notes boxes, and learning objectives focus your learning and make studying easier. Proprietary drug names are listed with the generic drug names, highlighting drugs that have generic options. Companion Evolve website includes drug administration videos, drug calculators with accompanying word problems, animations of pharmacologic processes, and dosage calculation exercises. Dosage calculation exercises provide practice immediately after new information is presented. Review questions reinforce your understanding of key concepts, with answers located in the back of the book. Technician Notes provide useful hints and important reminders to help you avoid common errors and increase your efficiency on the job. NEW! Emergency Drugs chapter is added. UPDATED drug information keeps veterinary students current with the newest pharmacologic agents and their uses, adverse side effects, and dosage forms. NEW! Case studies at the end of every chapter provide students with real-world scenarios.

Formerly titled "Pathology of the Fischer Rat, " "Boorman s Pathology of the Rat" continues to be the most comprehensive pathology reference and standard on rat strains. A vital resource for researchers across science and medicine using rat models in the laboratory, "Boorman s Pathology of the Rat" offers an added emphasis on the Sprague-Dawley and Wistar rat strains, in line with current research across academia, government, and industry. In addition, the book provides standard diagnostic criteria, basic content on histology, histological changes that result from drug toxicity and neoplasm, pathology terminology, and four-color photographs from the NTP archive and database.

With updated references and photographs, as well as coverage of all rat strains, "Boorman s Pathology of the Rat" is the standard in the field, invaluable to toxicologists, biologists, and other scientists engaged in regulatory toxicology who must make the transition from pathology results to promulgation of meaningful regulations.
Full-color photographs Coverage of all strains of rats Organ-by-organ and system-by-system approach Background incidence data Detailed descriptive content regarding changes in rat model during research"

Now in a revised edition, "Comparative Pharmacokinetics: Principles, Techniques, and Applications" presents the principles and techniques of comparative and veterinary pharmacokinetics in a detailed yet practical manner. Developed as a tool for ensuring that pharmacokinetics studies are properly designed and correctly interpreted, the book provides complete coverage of the conceptual basis of pharmacokinetics as used for quantifying biological processes from the perspectives of physiology and medicine. New chapters have been added on quantitative structure permeability relationships and bioequivalence, and a number of existing chapters have been significantly revised and expanded to provide a current resource for veterinary and comparative pharmacokinetics.

"Veterinary Pharmacovigilance: Adverse Reactions to Veterinary Medicinal Products" is an in-depth examination of veterinary pharmacovigilance, looking at the scientific methodologies involved, the role of regulatory agencies and legislation, and the underpinning science. Edited by a renowned expert with over 20 years of experience in the field, it draws together the expertise of authors from around the world.

This handbook is the first dealing with the discovery of drugs directed against apicomplexan parasites. Amongst others, this group of endoparasites includes the causative agents of Malaria, Toxoplasmosis, and Babesiosis, the latter occurring mainly in animals. Written by renowned scientific experts from academia and industry, the book focuses on currentdrug development approaches for all apicomplexan diseases making it appealing to a large audience, ranging from research labs in academia to the human and veterinarian pharmaceutical industry. This work is the second volume of the new book series 'Drug Discovery in Infectious Diseases', edited by Prof. Dr Paul M. Selzer.

A complete update on clinical pharmacology and therapeutics for the small animal practitioner! Topics will include regulatory aspects, pharmacokinetics and clinical practice, idiosyncratic drug toxicity, adverse drug interactions, feline deficiencies, antimicrobials, antibiotic treatment of resistant infections, outpatient analgesics, nutraceuticals, seizure management, immunosuppressive therapy, and much more!

Veterinary Pharmacology and Therapeutics, Tenth Edition is a fully updated and revised version of the gold-standard reference on the use of drug therapy in all major veterinary species. Provides current, detailed information on using drug therapies in all major domestic animal species Organized logically by drug class and treatment indication, with exhaustive information on the rational use of drugs in veterinary medicine Includes extensive tables of pharmacokinetic data, products available, and dosage regimens Adds new chapters on pharmaceutics, ophthalmic pharmacology, food animal pharmacology, and aquatic animal pharmacology Includes access to a companion website with the figures from the book in PowerPoint

The use of therapeutic and antimicrobial agents to prevent, to control, and to eradicate disease in herd animals has without question revolutionized food animal production capacity. But how much of a good thing is too much? 20th century advances in disease diagnosis and treatment have led to 21st century concerns about the health risks posed to consumers when the animals they consume have been exposed to antimicrobials, therapeutic drugs, pesticides and other environmental contaminants. The Food Animal Residue Avoidance Databank provides the pharmacologic data that veterinarians and producers need to screen animals that have been exposed to chemicals and to ensure that dangerously contaminated tissues of food-producing animals do not enter the human food chain.

Established only twenty years ago under the auspices of the USDA, FARAD is an international venture that brings together and collates information on applications of pharmacokinetic principles to drug and chemical residue avoidance--information that previously has been spread throughout the literature. Now, the "Tabulation of FARAD Comparative and Veterinary Pharmacokinetic Data "brings together in a single source all the most current information on chemical residues in food animals, and provides easy access and numerous tables that offer essential pharmacokinetic data for chemicals in serum, plasma, blood, or in other matrices. This updated one-of-a-kind volume also features additional data on laboratory rodents, dogs, cats, and horses to facilitate broader interspecies extrapolations.

This easy-to-use and newly-updated publication is the essential reference on the subject and belongs in the library ofveterinarians, toxicologists, pharmacologists, animal scientists, food hygienists, and regulatory personnel involved in human food safety.

Antiparasitic drugs (ATH) are important tools widely used to maintain animal welfare. As parasites impart a great impact on animal health, these drugs are often essential for the expression of the full genetic potential of production. However, despite the initial success, after years of massive use of anthelminthic drugs , the increase in prevalence of resistant nematodes became a major problem. Anthelmintics are commonly used to treat parasitic worm infections not only in animals, but humans as well. Resistance to anthelmintics is thought to be present in several helminth species, yet it remains poorly studied. This books discusses topics such as the clinical pharmacology of anthelmintics; the uses in human and veterinary medicine; animal resistance to ATH; and the efficacy of Neem and Pawpaw products against Oesophahostomum spp infection in pigs.

The U.S. market for pet medications is growing, and is in a state of transition. Although many pet owners continue to purchase their pet medications directly from veterinarians, this traditional distribution model has been challenged by the entry and expansion of retail businesses (both online and brick-and-mortar) that sell pet medications, as well as changes in the business practices of pet medication manufacturers, distributors, veterinarians, and retailers. This book provides an overview of the pet medications industry then examines prescription portability (prescriptions that can be filled by someone other than a veterinarian). The book also looks at distribution practices and the topic of generics. Recommendations on potential policy choices are made and areas that could benefit from additional study are identified.

Animal breeding has been complicated by persisting factors across species, cultures, geography, and time. In Made to Order, Margaret E. Derry explains these factors and other breeding concerns in relation to both animals and society in North America and Europe over the past three centuries. Made to Order addresses how breeding methodology evolved, what characterized the aims of breeding, and the way structures were put in place to regulate the occupation. Illustrated by case studies on important farm animals and companion species, the book presents a synthetic overview of livestock breeding as a whole. It gives considerable emphasis to genetics and animal breeding in the post-1960 period, the relationship between environmental and improvement breeding, and regulation of breeding as seen through pedigrees. In doing so, Made to Order shows how studying the ancient human practice of animal breeding can illuminate the ways in which human thinking, theorizing, and evolving characterize our interactions with all-natural processes.

Toxicological Effects of Veterinary Medicinal Products in Humans is the first definitive guide to discuss the adverse effects of veterinary medicinal products in humans. The chapters focus on occupational safety and consumer issues and examine the circumstances under which exposure is likely to occur. To be in context, it reviews this against the background of adverse health effects from other sources in the veterinary and farming professions. The book examines adverse drug effects reported to regulatory agencies (mainly the FDA's Center for Veterinary Medicine) and then considers a series of individual drugs, including antibiotics, anaesthetics and organophosphorus compounds. The chapters also discuss the fundamental aspects of regulatory issues relating to safety assessment, and examine the manner in which user safety is assessed prior to authorisation/approval and what measures can be taken after authorisation/approval in the light of findings from pharmacovigilance activities. There is growing concern over the issue of antimicrobial resistance and the contribution made by veterinary medicinal products. This too is addressed along with the significance to human health and measures that can be taken to mitigate the effects (if any) of the use of antibiotics in animals e.g. prudent use measures. The book will be an essential resource for medical practitioners in hospitals and general practice, pharmaceutical industry scientists, analysts, regulators and risk managers.

This book describes the most relevant information related to the chromatographic determination of veterinary drug residues in food, environmental and biological samples, providing the main applications performed in this type of matrices, as well as the main advances related to the chromatographic techniques.